New Method Generates Stem Cells Safely from Mice
Shinya Yamanaka of Kyoto University in Japan and colleagues invented a new way to transform ordinary cells into embryonic-like stem cells called iPS cells, using a ring of genetic material called a plasmid.
Newly Identified Cells Make Fat
Scientists at the Howard Hughes Medical Institute and Rockefeller University have discovered an important fat precursor cell that may in time explain how changes in the numbers of fat cells might increase and lead to obesity.
Study Unlocks Stem Cell, DNA Secrets to Speed Therapies
Florida State University researchers have discovered that as embryonic stem cells turn into different cell types, there are dramatic corresponding changes to the order in which DNA is replicated and reorganized.
Reversible 3D Cell Culture Gel Invented by IBN Published in Nature Nanotechnology
Singapore’s Institute of Bioengineering and Nanotechnology latest invention, a unique user-friendly gel that can liquefy on demand, has the potential to revolutionize three-dimensional cell culture for medical research.
Digital Zebrafish Embryo Provides the First Complete Developmental Blueprint of a Vertebrate
A new high-powered microscope has allowed scientists to watch a zebrafish develop from a single cell into an embryo with a beating heart, the first time this has been possible in vertebrates.
Can Stem Cells Heal Damaged Hearts? No Easy Answers, but some Signs of Hope
In a recent systematic review, Cochrane Researchers concluded that more clinical trials are needed to assess the effectiveness of stem cell therapies for heart patients.
Argos Therapeutics Publishes Approach to Improving Dendritic Cell-Based Immunotherapy
Argos Therapeutics recently announced the publication of a paper in the October 2008 issue of the Journal of Immunotherapy demonstrating that the Company’s process of maturing dendritic cells electroporated with antigen-encoded messenger RNA is capable of driving long-term, stable expansion of cytolytic antigen-specific T cells that express effector/memory phenotype.
Amsterdam Molecular Therapeutics Intends to Incorporate Additional Data to its Marketing Authorization Dossier for Glybera(R)
In consultation with the Rapporteur countries, Germany and the United Kingdom, of the European Medicines Agency and Health Canada, AMT has decided to expand the clinical experience and to augment the Marketing Authorization Application with an additional 16-patient study that will investigate the broader impact of this gene therapy on additional aspects of lipid metabolism.
Roger Tsien Wins 2008 Nobel Prize in Chemistry
The Royal Swedish Academy of Sciences announced recently that the 2008 Nobel Prize in Chemistry was awarded to Roger Y. Tsien, Osamu Shimomura, and Martin Chalfie for “the discovery and development of the green fluorescent protein, GFP.”
ABSTRACTS, REVIEWS AND SPECIAL REPORTS
Cells Derived from Human Umbilical Cord Blood Support the Long-Term Growth of Undifferentiated Human Embryonic Stem Cells
This study reports the successful culture of two hESC lines (H1 and H9) on human umbilical cord blood-derived fibroblast-like cells.
Unaltered Repopulation Properties of Mouse Hematopoietic Stem Cells Transduced with Lentiviral Vectors
The results of this study show unaltered repopulation properties of HSCs transduced with LVs, and confirm early studies suggesting the natural capacity of a few HSC clones to generate a monoclonal or oligoclonal hematopoiesis in transplant recipients.
Hepatic Microenvironment Programs Hematopoietic Progenitor Differentiation into Regulatory Dendritic Cells, Maintaining Liver Tolerance
The researchers demonstrate that the liver microenvironment is highly important to program progenitors to differentiate into regulatory dendritic cells in situ, which contributes to the maintenance of liver tolerance.
Hematopoietic Stem Cell Quiescence Is Maintained by Compound Contributions of the Retinoblastoma Gene Family
This study shows that Rb family members collectively maintain HSC quiescence and the balance between lymphoid and myeloid cell fates in the hematopoietic system.
Donating Embryos for Research may be Easier Said than Done
Obstacles to donating embryos include piles of paperwork, choosing the type of medical research, getting the consent of egg and sperm donors or simply finding an organization that will accept the donation.
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