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Looking At Neurons From All Sides
A new technique that marries a fast-moving laser beam with a special microscope that looks at tissues in different optical planes will enable scientists to get a three-dimensional view of neurons or nerve cells as they interact.
New Artificial Liver Tests: HepaLife’s ‘PICM-19’ Demonstrate Advantages Over Today’s Best-Available Liver Cells
HepaLife Technologies, Inc. recently announced that results from new tests of the Company’s patented PICM-19 liver cells show the highest levels of important liver-specific metabolic activity key to mimicking human liver function, and further demonstrate the PICM-19’s ability to perform equivalent to freshly harvested adult porcine hepatocytes, traditionally regarded the best available liver cell source for bioartificial liver support.
Tissue-Specific Blood Stem Cell Line Established From Embryonic Stem Cells
A research team at the Umea Center for Molecular Medicine in Sweden, led by Professor Leif Carlsson, has managed to specifically establish and isolate the tissue-specific stem cell that produces blood cells by using genetically modified embryonic stem cells.
Scientists Find Stem Cells For the First Time in the Pituitary
A team of researchers led by scientists at Cold Spring Harbor Laboratory have for the first time identified stem cells that allow the pituitary glands of mice to grow even after birth.
New Model for Embryonic Limb Development
A study led by USC researcher Francesca V. Mariani has found a new model to explain how signals between cells in the embryo control limb development.
Mouse Skin Cells Reprogrammed to Act Like Embryonic Stem Cells
Functioning cardiac cells have been created from mouse skin cells reprogrammed to have the same unlimited differentiation characteristics of embryonic stem cells, say researchers at the University of California, Los Angeles.
The Blind Can See
Dr. Awatramani and other neuroscientists developed a strategy to restore visual functions in mice with retinal degenerative diseases, a major advancement in retinal disease research.
New Findings Published in Nature Biotechnology Demonstrate Use of "Lipidoids" to Achieve Systemic Delivery of RNAi Therapeutics in Multiple Pre-Clinical Models
The studies showed successful delivery of lipidoid formulations of small interfering RNAs, the molecules that mediate RNAi, in multiple animal species including mice, rats, and non-human primates that together demonstrate potent, specific, and durable effects on gene expression in multiple tissues, including liver, lung, and peritoneal macrophages.
BioCardia and the University of Miami Receive FDA Clearance to Initiate Co-Sponsored Heart Failure Stem Cell Clinical Trial Comparing Two Cell Populations
BioCardia, Inc. and the University of Miami recently announced that the United States Food and Drug Administration approved a clinical investigation of two adult stem cell populations in the setting of heart failure.
Studies Test New Approaches to Islet Transplantation
Researchers from 11 medical centers in the United States, Canada, Sweden, and Norway have begun testing new approaches to transplanting clusters of insulin-producing islets in adults with difficult-to-control type 1 diabetes.
Cell-Based Therapy Shows Promise in Patients with Parkinson’s Disease
A novel cell therapy using retinal pigment epithelial cells attached to tiny gelatin bead microcarriers implanted in the brain can improve the symptoms of patients with moderate to advanced Parkinson’s disease.
Celgene Cellular Therapeutics Announces Clinical Transplant of Human Placenta-Derived Stem Cells
Celgene Cellular Therapeutics recently announced the clinical application of a human placenta-derived stem cells for hematopoietic reconstitution.
Quantum Immunologics, Inc. and the South Alabama Medical Science Foundation Announce an Early Clinical Evaluation of a Novel Immuno-therapeutic Vaccine for Treating Advanced Human Breast Carcinomas
Quantum Immunologics, Inc. announces the commencement of a Phase I/II clinical trial to assess the safety and efficacy of a novel anti-cancer vaccine/immunotherapy that will be used on patients with Stage IV advanced breast cancer.
ABSTRACTS, REVIEWS AND SPECIAL REPORTS
Acid Cleavable PEG-Lipids For Applications in a Ternary Gene Delivery Vector
Gene therapy has significant potential as treatment strategies for inherited or aquired diseases, however, an efficient vector system is required to deliver the gene of interest into target cells. To improve the efficacy and selectivity of synthetic vectors, targeting to cell-surface receptors using peptides, polysaccharides or antibodies has been carried out.
Bone Marrow–Derived Mesenchymal Stem Cells Facilitate Engineering of Long-Lasting Functional Vasculature
Vascular tissue engineering requires a ready source of endothelial cells and perivascular cells. Here, the researchers evaluated human bone marrow–derived mesenchymal stem cells for use as vascular progenitor cells in tissue engineering and regenerative medicine.
Localization and Characterization of STRO-1+ Cells in the Deer Pedicle and Regenerating Antler
Studying antler regeneration can provide a deeper insight into the mechanisms that prevent limb regeneration in humans and other mammals, and, with regard to medical treatments, may possibly even show ways how to overcome these limitations. The researchers results support the view that the annual process of antler regeneration might depend on the periodic activation of mesenchymal progenitor cells located in the pedicle periosteum.
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