7th International Stem Cell Conference, Oct. 29-30, Pittsburgh, PA
The conference features top level keynotes and the latest research updates plus structured sessions facilitating networking with the FDA, NIH and leading researchers from: Wake Forest University, San-Bio, Athersys Inc., Fred Hutchinson Cancer Research Center, Progenitor Cell Therapy, OncoMed, Neuro Generation, Novocell Inc., Merck, and Genzyme Inc.
To register visit www.almevents.com/stemcell or phone 1-800-599-4950.
Stomach Stem Cell Discovery Could Bring Cancer Insights
A group of University of Michigan Medical School researchers has succeeded in finding and manipulating a population of cells that strongly resemble stem cells in the stomachs of mice.
Study Reveals How Stem Cells Decide To Become Either Skeletal or Smooth Muscle
The results not only provide insight into the development of muscle types in the human fetus, but also suggest new ways to treat atherosclerosis and cancer, diseases that involve the creation of new blood vessels from stem cell reserves that would otherwise replace worn out skeletal muscle.
Adult Stem Cells Lack Key Pluripotency Regulator
The protein Oct4, which helps to maintain embryonic stem cells, has been shown to be virtually absent in adult stem cells. Using three independent detection techniques on six tissue types where Oct4 expression had been reported, researchers found Oct4 either was not present or was present at statistically insignificant levels.
Neighborly Care Keeps Stem Cells Young
A stem cells’ immediate neighborhood, a specialized environment also known as the stem cell niche, provides crucial support needed for stem cell maintenance. But nothing lasts forever, found scientists at the Salk Institute for Biological Studies. During the aging process, the level of support drops off, diminishing the stem cells’ ability to replenish themselves indefinitely.
Xie Lab Demonstrates Dual Intrinsic and Extrinsic Control of Stem Cell Aging
The Stowers Institute’s Xie Lab has published recent findings that reveal some of the factors underlying the aging of stem cells.
Stem Cell Nuclei Are Soft ‘Hard Drives,’ Penn Study Finds
Biophysicists at the University of Pennsylvania have discovered that the nuclei of human stem cells are particularly soft and flexible, rather than hard, making it easier for stem cells to migrate through the body and to adopt different shapes, but ultimately to put human genes in the correct nuclear “sector” for proper access and expression.
Researchers Mimic Vascular System to Nourish Engineered Tissue for Transplants
The researchers have engineered tiny channels within a water-based gel that mimic a vascular system at the cellular scale and can supply oxygen, essential nutrients and growth factors to feed individual cells. The so-called gel scaffold can hold tens of millions of living cells per milliliter in a 3-D arrangement, such as in the shape of a knee meniscus, to create a template for tissue to form.
Jefferson Urologists Studying Regenerated Neo-Bladder to Help Spinal Cord Injury Patients
Urologists at Thomas Jefferson University Hospital are studying whether a neo-bladder construct grown from a patient’s own cells can improve bladder function for adult spinal cord injury patients.
BrainStorm on the Verge of a Breakthrough Towards Developing a Cure for Lou Gehrig’s Disease
BrainStorm Cell Therapeutics Inc. has announced that the Company is initiating a series of efficacy and safety studies toward a cure for Amyelotrophic Lateral Sclerosis.
One Shot of Gene Therapy Spreads Through Brain in Animal Study
By targeting a site in a mouse brain well connected to other areas, researchers successfully delivered a beneficial gene to the entire brain—after one injection of gene therapy. If these results in animals can be realized in people, researchers may have a potential method for gene therapy to treat a host of rare but devastating congenital human neurological disorders, such as Tay-Sachs disease.
Clinical Trials for Blindness and Hemophilia Gene Transfer Underway
One gene transfer approach under investigation, which was developed by University of Pennsylvania investigator Jean Bennett, M.D., Ph.D., uses adeno-associated viral vector to deliver the gene for RPE65 into the eye. Catherine Manno, M.D., Division of Hematology, leads the center’s second gene transfer clinical trial. This trial focuses on hemophilia B, a bleeding disorder that results from a deficiency of blood coagulation factor IX.
Positive Preliminary Data on DiabeCell Phase I/IIa Clinical Trial
Living Cell Technologies Ltd is releasing this announcement concerning positive results of its Russian diabetes transplant trial to ensure that clinical information is available to all shareholders.
Blood Vessels Grown From Patient’s Skin
From a snippet of a patient’s skin, researchers have grown blood vessels in a laboratory and then implanted them to restore blood flow around the patient’s damaged arteries and veins.
FDA Approves Knee-injury Device For Humans
A new knee-surgery device investigated by University of Missouri-Columbia researchers that will help to repair meniscus tears, which were previously defined as irreparable, has been approved by the FDA for use in humans.
Cytori’s Celution(TM) System Approved in Japan for Stem Cell Collection & Preservation
Cytori Therapeutics received approval in Japan on the Celution(TM) System for use in medical laboratories for stem cell collection and preservation procedures.
FDA Approves ThermoGenesis’ Cord Blood Processing System
ThermoGenesis Corp.’s AXP AutoXpress Platform has been approved by the U.S. Food and Drug Administration, a critical step in the Rancho Cordova company’s effort to process, store and administer adult stem cells for the treatment of injuries and diseases.
Biologist Ian Wilmut talks about his cloning plans for the future.
ABSTRACTS, REVIEWS AND SPECIAL REPORTS
Oct4 Expression Is Not Required for Mouse Somatic Stem Cell Self-Renewal
The researchers employed a genetic approach to determine whether Oct4 is important for maintaining pluripotency in the stem cell compartments of several somatic tissues, including the intestinal epithelium, bone marrow (hematopoietic and mesenchymal lineages), hair follicle, brain, and liver. Oct4 gene ablation in these tissues revealed no abnormalities in homeostasis or regenerative capacity.
Cell Therapeutics Supervisor
Philadelphia, PA (AppTec)
Sweden (Wallenberg Neuro Center Neuronal Survival Unit)
Memphis, TN (Cognate Bioservices)