Osiris Therapeutics Reports Positive Phase II Results Using PROCHYMAL™ for the Treatment of Acute Graft vs. Host Disease
23 patients, or 74% achieved a complete response, meaning the patients had experienced total clinical resolution of the disease. Currently, PROCHYMAL is being evaluated in a Phase III trial for the treatment of steroid refractory GVHD.
Dendreon Announces New Data Analysis Presented at Chemotherapy Foundation Symposium
Dendreon Corporation today announced the presentation of data from an exploratory analysis of Phase 3 Studies (D9901 and D9902A) that showed a prolonged survival benefit for patients initially treated with PROVENGE® (sipuleucel-T) who then went on to receive docetaxel chemotherapy after disease progression. PROVENGE is the Company’s lead investigational active cellular immunotherapy for the treatment of advanced prostate cancer.
Cord Stem Cells Turned into Lung Cells
“In the future, we may be able to examine cord blood from babies who have lung diseases, such as cystic fibrosis, to do more research to understand how these diseases evolve, as well as to develop better medical treatments,” David McKenna, medical director of the Clinical Cell Therapy Lab at the University of Minnesota Medical Center in Minneapolis, said.
U of M Receives $1.5 Million to Research Stem Cell Treatments for Heart Disease
The University of Minnesota is one of five institutions across the country chosen to receive $1.5 million from the National Institutes of Health (NIH) to research stem cell treatments for heart disease.
Stem Cells Hold Promise For Diabetes Cure
A research team form the New Orleans’ Tulane University reveals that stem cells hold promise for diabetes cure. Researchers have used stem cells from human bone marrow to successfully treat diabetic mice.
Transplanted Retinal Cells Let Blind Mice See Again
A team of British scientists using cellular implants has restored sight in adult mice — possibly paving the
Uterus Transplant Could be Tomorrow
Last month Del Priore and colleagues at the University of Pittsburgh’s primate research laboratory performed the first successful uterus transplant in a non-human primate.
Stretching Bone Marrow Stem Cells Pushes Them Towards Becoming Blood Vessel
When stretched, a type of adult stem cell taken from bone marrow can be nudged towards becoming the type of tissue found in blood vessels, according to a new study by bioengineers at the University of California, Berkeley.
How To Grow Muscle Cells In A Dish
In a study that appears online on November 9, in advance of publication in the December print issue of the Journal of Clinical Investigation, Catherine Verfaille and colleagues at the University of Minnesota Medical School, Minneapolis, show that SMCs can be generated from multipotent adult progenitor cells (MAPCs) isolated from the bone marrow of rats, mice, pigs, and humans.
Researchers Identify Cells that make Relapse Inevitable in Acute Lymphoblastic Leukemia
In “Dr Jekyll and Mr Hyde” Robert Louis Stevenson wrote about the good and evil sides of the same person; now scientists in Australia have discovered that in acute lymphoblastic leukaemia (ALL) there are Dr Jekyll and Mr Hyde cells – “good” and “evil” clones of the same type of ALL cell. The “evil” cells are clones that have a pre-existing, rather than acquired, resistance to drugs used for treating ALL, and their presence in a patient means that person will inevitably relapse after chemotherapy, however well they respond initially.
Doctors Now Back Face Transplants
Leading doctors have given cautious backing to face transplants.
Mass Producing Engineered Organs
Bioartificial kidneys seem to work, but can we make enough for everyone who needs one?
Gene Therapy Inhibits Epilepsy In Animals
For the first time, researchers have inhibited the development of epilepsy after a brain insult in animals.
Scientists Find Problem & Possible Solution In Gene Therapy Delivery
“No one in protein or DNA therapeutics had considered cavitation as a problem,” notes Dr. Corinne Lengsfeld, “but cavitation occurs in every biotech processing system. We now know that if you can keep your turbulent eddy size bigger than the DNA, it will never fragment.”
Plan to Create Human-cow Embryos
UK scientists have applied for permission to create embryos by fusing human DNA with cow eggs.
Cell Transfer for Heart Patient
A man who has had six heart attacks is one of the first UK patients to undergo an experimental cell transfer.
Lung-Cancer Vaccine with Stem Cells Successful on Mice
Researchers at the University of Louisville have developed a lung-cancer vaccine using embryonic stem cells that has proven to be effective in mice.
Diabetes Shouldn’t Keep Patients From Heart Transplant
Diabetes alone should not disqualify a person from being considered for a heart transplant, U.S. researchers conclude. They found that it is the severity of diabetes damage to the body, not the illness itself, that plays the critical role in heart transplant success.
Researchers Map Protein Network that Regulates “Stemness”
Howard Hughes Medical Institute (HHMI) researchers have created a map that charts the largely unexplored protein landscape that regulates a stem cell’s ability to differentiate into multiple types of mature cells.
ABSTRACT, REVIEWS & SPECIAL REPORTS
Cytokine-induced Differentiation of Multipotent Adult Progenitor Cells into Functional Smooth Muscle Cells
Multipotent adult progenitor cells (MAPCs) isolated from rat, murine, porcine, and human bone marrow demonstrate the potential to differentiate into cells with an SMC-like phenotype and function. TGF-1 alone or combined with PDGF-BB in serum-free medium induces a temporally correct expression of transcripts and proteins consistent with smooth muscle development.