First Embryonic Stem Cell Trial on the Cards
A US team hopes to be in clinical trials next year, using an ESC-derived product to help repair damaged spinal tissue.
Study of Adult Stem Cells in the Treatment of Multiple Sclerosis Begins in Charleston
D-Finitive Technologies, Inc. has announced that a preliminary phase of animal testing of transfected adult stem cells is now underway that may lead to advances in the treatment of Multiple Sclerosis.
Adult Stem Cell Research at University of Buffalo Targets Damaged Hearts
A specialist in stem cell biology at the University at Buffalo has received a $1.98 million grant from National Institutes of Health to investigate the potential of bone marrow-derived adult stem cells to treat the serious heart malfunction known as hibernating myocardium.
University of California Researchers Develop ‘Smart Petri Dish’
Researchers at the University of California, San Diego have developed what they call a “Smart Petri Dish” that could be used to rapidly screen new drugs for toxic interactions or identify cells in the early stages of cancer circulating through a patient’s blood.
Gene Therapy Injected into the Brains’ of Mice with Huntington’s Disease Protects Neurons, Stops Degeneration and Improves Behavioral Function
Researchers at Rush University Medical Center, Chicago, and Ceregene Inc., San Diego, have successfully used gene therapy to preserve motor function and stop the anatomic, cellular changes that occur in the brains of mice with Huntington’s disease (HD).
Stem Cells Found In Adult Skin Can Be Transplanted And Function In Mouse Models Of Disease
Researchers at The Hospital for Sick Children (SickKids) and the University of Calgary have found that stem cells derived from adult skin can create neural cell types that can be transplanted into and function in mouse models of disease.
Research at University of Washington May Hold Promise for Liver Damage
Scientists at the University of Washington are optimistic that they’ve made what they call meaningful progress toward learning how to repair damaged human livers with stem cells.
Advanced Donor Age Reduces Quality of Islet Cells Used in Transplantation
Experiments in diabetic mice have demonstrated that the age of islet cell donors affects the efficacy of transplants, transplant surgeons at the University of Minnesota, Minneapolis, report.
New Step Toward Treatment For Duchenne Muscular Dystrophy
After performing the first successful muscle cell transplant in young patients two years ago, professor Tremblay announced that eight out of the nine patients have shown promising results.
Favrille Announces FDA Allowance of Investigational New Drug Application for FAV-201, a Patient-Specific Immunotherapy for T-Cell Lymphoma
Favrille, Inc. (Nasdaq: FVRL – News), a biopharmaceutical company developing patient-specific immunotherapies for the treatment of cancer, announced today that its electronic Investigational New Drug (IND) application for FAV-201, a patient-specific immunotherapy for the treatment of T-cell lymphoma, has been cleared by the U.S. Food & Drug Administration (FDA).
Baylor College of Medicine and St. Luke’s Episcopal Hospital Study Uses Gene Therapy as Treatment for Pancreatic Cancer
The use of gene therapy alongside the standard treatment for pancreatic cancer is being studied by researchers at the Elkins Pancreas Center at Baylor College of Medicine and St. Luke’s Episcopal Hospital.
Novocell Presents Phase I/II Data on Safety and Response to Encapsulated Islets at the American Diabetes Association’s 66th Annual Scientific Session
The poster entitled “Encapsulated Human Islet Allografts — Phase I/II Clinical Trial” described safety and efficacy results following subcutaneous implants of encapsulated human islet allografts into patients with Type I diabetes of long standing duration.
Dendreon Announces Publication of Research Showing Promising Activity of PROVENGE in Combination with Avastin in Patients with Recurrent Early Stage Prostate Cancer
Dendreon Corporation has announced that the results from a National Cancer Institute (NCI)-sponsored Phase 2 study of its PROVENGE® (sipuleucel-T) active cellular immunotherapy for prostate cancer in combination with Avastin® (bevacizumab) have been published in the July issue of the American Cancer Society’s journal, Cancer.
IDM Pharma Receives Special Protocol Assessment from FDA for Phase 2/3 Trial of Bexidem for Superficial Bladder Cancer
IDM Pharma Inc. announced today that it has received a Special Protocol Assessment (SPA) from the U.S. Food and Drug Administration (FDA) for the planned Phase 2/3 clinical trial in the U.S. of Bexidem for the treatment of superficial bladder cancer.
Genitope Cancer Treatment on Fast Track
Genitope Corp. said Tuesday the Food and Drug Administration gave its cancer treatment candidate, MyVax, Fast Track status.
Amgen Cancer Drug Panitumumab Gets FDA Priority Review
Amgen, the world’s largest biotechnology company, today announced that the U.S. Food and Drug Administration (FDA) has accepted the Biologic License Application (BLA) for panitumumab, an investigational fully human monoclonal antibody that targets the epidermal growth factor receptor (EGFr) and has granted Priority Review.
Genes Governing Embryonic Stem Cell “Immortality” Discovered
New research has uncovered some of the genes that allow embryonic stem cells to renew themselves.
New Stem-cell Findings Can Help The Body To Cure Itself
Researchers at Karolinska Institutet have identified an important mechanism that regulates how many new cells are produced by each intestinal stem cell.
Scientists Tie Several Cancers to Common “Oncogene Engine”
Researchers at Dana-Farber Cancer Institute report that a common “oncogene engine” – a small family of malfunctioning cell growth switches – drives several seemingly unrelated, lethal forms of cancer, including malignant melanoma.
Software Tracks Proteins Inside Living Cells
A computer system that automatically tracks the movements of proteins within a living cell has been developed by a team of biologists and computer vision experts.
Joslin Diabetes Center Study Refutes Recent Report that Bone Marrow Can Replenish Female Oocytes
Study shows that circulating bone-marrow derived cells do not contribute to egg formation.
ABSTRACTS, REVIEWS & SPECIAL REPORTS
Nanog Promotes Transfer of Pluripotency After Cell Fusion
The researchers conclude that Nanog can orchestrate ES cell machinery to instate pluripotency with an efficiency of up to 100% depending on the differentiation status of the somatic cell.
Dissecting Self-Renewal in Stem Cells with RNA Interference
The researchers use short hairpin RNA (shRNA) loss-of-function techniques to downregulate a set of gene products whose expression patterns suggest self-renewal regulatory functions. Their studies suggest specific biological roles for these molecules and reveal the complexity of cell fate regulation in embryonic stem cells.