Minimal Cocktail for Growing Human Embryonic Stem Cells Established
Researchers at Yale have established the minimal nutritional requirements for growing and maintaining human embryonic stem cells, a recipe that is critical for clinical application and for developmental studies, according to an early online report this week in Proceedings of the National Academy of Sciences.
Engineered Stem Cells Show Promise for Sneaking Drugs Into The Brain
Scientists have found a new way to sneak drugs past the blood-brain barrier by engineering and implanting progenitor brain cells derived from stem cells to produce and deliver a critical growth factor that has already shown clinical promise for treating Parkinson’s disease.
Getting ACL Tears to Heal Themselves
In the April Journal of Orthopaedic Research, orthopedic surgeon Martha Murray, MD reports that a collagen gel, enriched with blood platelets, can stimulate natural healing of a partial ACL tear, encouraging the body’s cells to fill in the defect and restore mechanical strength to the ligament.
Transplanted Mice Cells Ease Rat Paralysis
Scientists eased the paralysis of rats with spinal cord injury by transplanting cells taken from the brains of adult mice, an encouraging sign for developing a human treatment.
Generating Egg-like Cells from Pig Fetal Skin
Julang Li and colleagues show that even post-embryonic somatic stem cells (derived from later stages of foetal development) can give rise to egg-like cells in vitro.
Periosteal Cells Grow Cartilage, Bone, and Skeletal Muscle
Cultured adult human periosteal stem cells demonstrate mesenchymal multipotency, suggesting that they may be used to repair tissue and joint damage associated with arthritis.
Rice University Bioengineers Pioneer Techniques for Knee Repair
A breakthrough self-assembly technique for growing replacement cartilage offers the first hope of replacing the entire articular surface of knees damaged by arthritis.
First Clinical Trial of Gene Therapy for Muscular Dystrophy Now Under Way
The clinical trial for Duchenne muscular dystrophy (DMD) tests the safety and effectiveness of a therapy that was developed over two decades by scientists at the University of North Carolina at Chapel Hill’s School of Medicine and the University of Pittsburgh.
Brain Cells Fused with Computer Chips
European researchers have created an interface between mammalian neurons and silicon chips.
DNA Gene Vaccine Protects Against Harmful Protein of Alzheimer’s Disease
Doses of DNA-gene-coated gold particles protect mice against a protein implicated in Alzheimer’s disease.
Doctor is Charged with Therapy Scam
The Atlantic County physician allegedly bilked patients by offering a bogus stem-cell treatment.
Researchers Create Pigs That Produce Heart-Healthy Omega-3 Fatty Acids
Researchers report they have created pigs that produce omega-3 fatty acids, which are known to improve heart function and help reduce the risks for heart disease, representing the first cloned transgenic livestock in the world that can make the beneficial compound.
Stem cells, Gene Therapy and Allograft Applications Show Promise for Treating Orthopaedic Conditions
Recent advances in gene therapy, stem cells and other promising applications are offering new hope for patients and helping orthopaedic surgeons provide state-of-the-art treatment for various frame-related conditions.
ABSTRACTS, REVIEWS & SPECIAL REPORTS
Genospheres: Self-Assembling Nucleic Acid-Lipid Nanoparticles Suitable for Targeted Gene Delivery
This work describes a novel, readily scalable method for preparing highly stable immunotargeted nucleic acid delivery vehicles capable of achieving a high degree of specific transfection activity.
Human Neural Progenitors Deliver Glial Cell Line-Derived Neurotrophic Factor to Parkinsonian Rodents and Aged Primates
hNPC can be genetically modified, and thereby represent a safe and powerful option for delivering growth factors to specific targets within the central nervous system for diseases such as Parkinson’s.
Delayed Transplantation of Adult Neural Precursor Cells Promotes Remyelination and Functional Neurological Recovery after Spinal Cord Injury
The data provides strong evidence in support of the feasibility of adult NPCs for cell-based remyelination after SCI.
In Vitro Germline Potential of Stem Cells Derived from Fetal Porcine Skin
We report that stem cells isolated from the skin of porcine fetuses have the intrinsic ability to differentiate into oocyte-like cells.