Volume 21.24 | Jul 6

2020-07-06 | CTN 21.24
Cell Therapy News by STEMCELL Technologies
Vol. 21.24 – 6 July, 2020
TOP STORY

CAR-Modified Memory-Like NK Cells Exhibit Potent Responses to NK-Resistant Lymphomas

Peripheral blood memory-like ML NK cells were modified to express an anti-CD19 CAR, which displayed significantly increased IFN-γ production, degranulation, and specific killing against NK-resistant lymphoma lines and primary targets, compared to non-specific control CAR-ML NK cells or conventional CAR NK cells.
[Blood]

Abstract

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PUBLICATIONSRanked by the impact factor of the journal

Treatment with shCCL20-CCR6 Nanodendriplexes and Human Mesenchymal Stem Cell Therapy Improves Pathology in Mice with Repeated Traumatic Brain Injury

Researchers developed a combined nano-cell therapy by using dendrimers complexed with plasmids targeting CCL20 and its sole receptor CCR6 to reduce inflammation followed by human mesenchymal stem cell transplantation.
[Nanomedicine-Nanotechnology Biology and Medicine]

AbstractGraphical Abstract

Long-Term Outcomes of Cultivated Cell Sheet Transplantation for Treating Total Limbal Stem Cell Deficiency

This study was conducted to determine the long-term outcomes of cultivated cell sheet transplantation, and to clarify risk factors that affected the outcomes.
[Ocular Surface]

Abstract

Lung Delivery of MSCs Expressing Anti-Cancer Protein TRAIL Visualized with 89Zr-Oxine PET-CT

Investigators demonstrated 89Zr-oxine labeling and PET-CT imaging as a potential clinical solution for non-invasively tracking MSCTRAIL biodistribution.
[Stem Cell Research & Therapy]

Full Article

Phase I Dose Escalation Study of Naive T-Cell Depleted Donor Lymphocyte Infusion following Allogeneic Stem Cell Transplantation

In this Phase I dose escalation study, the authors assessed the safety of a donor lymphocyte infusion that was depleted of CD45RA+ naive T cells.
[Bone Marrow Transplantation]

Abstract

Bone Marrow-Derived Mesenchymal Stem Cells Improve Cognitive Impairment in an Alzheimer’s Disease Model by Increasing the Expression of MicroRNA-146a in Hippocampus

Investigators showed that intracerebroventricularly injected bone marrow mesenchymal stem cells improved cognitive impairment in Alzheimer’s disease model mice by ameliorating astrocytic inflammation as well as synaptogenesis.
[Scientific Reports]

Full Article

DLL4 Restores Damaged Liver by Enhancing hBMSC Differentiation into Cholangiocytes

Scientists aimed to determine whether human bone marrow mesenchymal stem cells could differentiate into biliary epithelial cells in vitro and in vivo and to clarify the role of delta-like ligand 4 (DLL4) in restoring damaged liver by enhancing cholangiocyte differentiation.
[Stem Cell Research]

Abstract

Endothelial Progenitor Cell Transplantation Restores Vascular Injury in Mice after Whole-Brain Irradiation

Flow cytometry demonstrated that irradiation led to a significant reduction in the peripheral blood endothelial progenitor cell (EPC) count; however, EPC transplantation led to a significant increase in the circulating EPCs.
[Brain Research]

Abstract

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REVIEWS

Gene and Stem Cell Therapies for Fetal Care: A Review

Fetal stem cell and gene therapy bring important therapeutic opportunities for select disorders that present in the fetal and neonatal periods. While this field is in its infancy, these therapies are starting to be available clinically, and clinicians should be aware of their benefits and challenges.
[JAMA Pediatrics]

Abstract

CRISPR/Cas9 in Male Factor Infertility

Application of CRISPR/Cas9 to the investigation and treatment of male infertility holds promise in identifying novel genetic causes of non-obstructive azoospermia.
[Current Tissue Microenvironment Reports]

Full Article

INDUSTRY AND POLICY NEWS

Adverum Biotechnologies Announces Completion of Patient Dosing in Cohort 4 of the OPTIC Phase I Trial of ADVM-022 Single Injection Gene Therapy for Wet AMD

Adverum Biotechnologies, Inc. announced the completion of patient dosing in Cohort 4 of OPTIC, a Phase I clinical trial, assessing a single intravitreal injection of ADVM-022 in patients with wet age-related macular degeneration.
[Adverum Biotechnologies, Inc.]

Press Release

Celixir Provides Update on Ongoing Clinical Program with Lead Therapeutic Candidate CLXR-001

Celixir announced an update to its ongoing clinical programme with lead therapeutic candidate CLXR-001.
[Celixir (GlobeNewswire, Inc.)]

Press Release

AVROBIO Announces New Patients Dosed in Gaucher Disease and Cystinosis Clinical Trials

AVROBIO, Inc. announced that the first patient has been dosed in the company’s GuardOne clinical trial, a Phase I/II investigational study evaluating AVR-RD-02 for Gaucher disease type 1.
[AVROBIO, Inc.]

Press Release

Hong Kong Universities Rattled by New Security Law

Academics in Hong Kong are facing new worries today after the mainland government abruptly imposed a controversial new security law that critics say could infringe on human rights and chill academic freedom.
[ScienceInsider]

Editorial

FEATURED EVENT

The New York Stem Cell Foundation (NYSCF) Conference

October 20 – October 21
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JOB OPPORTUNITIES

Engineer – Cell Therapy

Oslo University Hospital – Oslo, Norway

Senior Scientist – Process Development Lab, Gene and Cell Therapy

Genezen Laboratories – Indianapolis, Indiana, United States

Quality Control Manager – Gene and Cell Therapy

Genezen Laboratories – Indianapolis, Indiana, United States

Scientific Project Manager – Neurofibromatosis Type 1 Gene Therapy

Gilbert Family Foundation – Detroit, Michigan, United States

Postdoctoral Fellow – Immune and Stem Cell Engineering

Terasaki Institute for Biomedical Innovation – Los Angeles, California, United States

Faculty Positions – Regenerative Medicine

Guangzhou Regenerative Medicine and Health Guangdong Laboratory – Guangzhou, China

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