Volume 21.22 | Jun 22

2020-22-06 | CTN 21.22
Cell Therapy News by STEMCELL Technologies
Vol. 21.22 – 22 June, 2020

Immunity-and-Matrix-Regulatory Cells Derived from Human Embryonic Stem Cells Safely and Effectively Treat Mouse Lung Injury and Fibrosis

Intravenous delivery of immunity- and matrix-regulatory cells, derived from human embryonic stem cells, inhibited both pulmonary inflammation and fibrosis in mouse models of lung injury, and significantly improved the survival rate of the recipient mice in a dose-dependent manner, likely through paracrine regulatory mechanisms.
[Cell Research]

Full Article

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Engraftment Kinetics after Transplantation of Double Unit Cord Blood Grafts Combined with Haplo-Identical CD34+ Cells without Antithymocyte Globulin

Scientists investigated adding haplo-identical CD34+ cells to double unit cord blood (CB) grafts to facilitate early haplo-identical donor-derived neutrophil recovery prior to CB engraftment.


Human Gingiva-Derived Mesenchymal Stem Cells Are Therapeutic in Lupus Nephritis through Targeting of CD39-CD73 Signaling Pathway

Investigators demonstrated that the adoptive transfer of gingiva derived mesenchymal stem cells homes to and maintains in the kidney and had a robust therapeutic effect in a spontaneous lupus nephritis model.
[Journal of Autoimmunity]


Bone Regeneration Capacities of Alveolar Bone Mesenchymal Stem Cells Sheet in Rabbit Calvarial Bone Defect

Scientists compared the osteogenic differentiation and bone defect repairment characteristics of bone marrow mesenchymal stem cells sheets derived from alveolar bone and iliac bone in vitro and in vivo.
[Journal of Tissue Engineering]

Full Article

Effect of Amniotic Fluid Stem Cell Transplantation on the Recovery of Bladder Dysfunction in Spinal Cord-Injured Rats

The effects of human amniotic fluid stem cell transplantation on bladder function and molecular changes in spinal cord-injured rats were investigated.
[Scientific Reports]

Full Article

Quantitative Hybrid Cardiac [18F]FDG-PET-MRI Images for Assessment of Cardiac Repair by Pre-Conditioned Cardiosphere Derived Cells

Scientists enhanced the effect of cardiosphere-derived cells with APOSEC preconditioning (apoCDC), and investigated the reparative effect in a translational pig model of reperfused MI.
[Molecular Therapy-Methods & Clinical Development]

AbstractFull ArticleGraphical Abstract

Anti-Relapse Effects of Donor Natural Killer Cells and IL-2 Gene Modification on Allogeneic Hematopoietic Stem Cell Transplantation in Acute Leukemia

The authors investigated whether donor natural killer cells and interleukin-2 gene modification exerted anti-relapse effects on allogeneic hematopoietic stem-cell transplantation after establishing a mouse model of acute leukemia.
[Cancer Biomarkers]


Virtual Conference Exhibition: Pluripotent Stem Cells

Regenerative Potential of Wharton’s Jelly‐Derived Mesenchymal Stem Cells: A New Horizon of Stem Cell Therapy

The authors summarize the current preclinical and clinical studies performed to investigate the regenerative potential of Wharton’s jelly‐derived mesenchymal stem cells in neural, myocardial, skin, liver, kidney, cartilage, bone, muscle, and other tissue injuries.
[Journal of Cellular Physiology]



UCLA Receives Nearly $14 Million from NIH to Investigate Gene Therapy to Combat HIV

UCLA researchers and colleagues have received a $13.65 million grant from the National Institutes of Health (NIH) to investigate and further develop an immunotherapy known as CAR T, which uses genetically modified stem cells to target and destroy HIV.
[University of California, Los Angeles]

Press Release

Ovid Therapeutics Announces Strategic Research Collaboration Focused on Accelerating the Development of New Treatments for Rare Neurological Diseases

Ovid Therapeutics Inc. announced a strategic research collaboration with Columbia University Irving Medical Center researchers to advance genetic based therapies for a range of rare neurological conditions, complementary to Ovid’s current pipeline.
[Ovid Therapeutics Inc.]

Press Release

City of Hope Signs Licensing Agreement with Scopus BioPharma Inc. to Develop Novel, Targeted Immuno-Oncology Gene Therapy

City of Hope have signed an exclusive, worldwide licensing agreement with Scopus BioPharma Inc. Scopus will further develop and plans to commercialize a City of Hope first-in-class, targeted immuno-oncology gene therapy.
[City of Hope]

Press Release


International Society for Stem Cell Research (ISSCR) Virtual Annual Meeting 2020

2020-06-23 – 2020-06-27

> See All Events


Scientific Project Manager – Neurofibromatosis Type 1 Gene Therapy

Gilbert Family Foundation – Detroit, Michigan, United States

Postdoctoral Fellow – Immune and Stem Cell Engineering

Terasaki Institute for Biomedical Innovation – Los Angeles, California, United States

Faculty Positions – Regenerative Medicine

Guangzhou Regenerative Medicine and Health Guangdong Laboratory – Guangzhou, China

Chair – Bioengineering

University of Washington – Seattle, Washington, United States

Lab Director – Cancer Immunotherapy

Vrije Universiteit Brussels – Brussels, Belgium

Principal Scientist – Human iPSC Gene Engineering

Empyrean Therapeutics Ltd – Cambridge, United Kingdom

Postdoctoral Position – RNA Editing and Immunotherapy

University of Chicago – Chicago, Ilinois, United States

Postdoctoral Fellow – CRISPR Research

Boston Children’s Hospital – Boston, Massachusetts, United States

Postdoctoral Fellow – Cancer Adoptive Cell Immunotherapy

Wake Forest School of Medicine – Winston Salem, North Carolina, United States

Postdoctoral Position – CRISPR/Cas Genetic Engineering

Aarhus University – Aarhus C, Denmark

Professor Positions – Biomedical Sciences

The Chinese University of Hong Kong – Hong Kong, China

> See All Jobs

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