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Immunotherapy Achieves Breakthrough Result in Patients with Hodgkin Lymphoma
A therapy that liberates the immune system to attack cancer cells drove Hodgkin lymphoma into complete or partial remission in fully 87 percent of patients with resistant forms of the disease who participated in an early-phase clinical trial. The results provide some of the most dramatic evidence to date of the potential of therapies that increase the ability of the immune system to kill cancer cells. [Press release from Dana-Farber Cancer Institute discussing online prepublication in the New England Journal of Medicine]
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Two Leading Stem Cell and Regenerative Medicine Advocacy Groups Announce Merger Plan
The Genetics Policy Institute and the Regenerative Medicine Foundation have agreed to merge in order to leverage their resources in the advancement of stem cell research, regenerative medicine and other advanced technologies targeting cures. [Genetics Policy Institute (GlobeNewswire, Inc.)] Press Release
FDA Approves BLINCYTO™ (Blinatumomab) Immunotherapy for the Treatment of Relapsed or Refractory B-Cell Precursor Acute Lymphoblastic Leukemia
Amgen announced that the U.S. Food and Drug Administration (FDA) has granted approval of BLINCYTO™ for the treatment of patients with Philadelphia chromosome-negative relapsed or refractory B-cell precursor acute lymphoblastic leukemia. [Amgen Inc.] Press Release
Prothena Initiates NEOD001 Global Phase III Registrational Trial Based on Positive Results in Ongoing Phase I/II Study of NEOD001 in Patients with AL Amyloidosis
Prothena Corporation plc announced the initiation of the VITAL Amyloidosis Study, an international, multi-center, registrational Phase III clinical trial, based on positive results from an ongoing Phase I/II clinical study of NEOD001 in patients with AL amyloidosis and persistent organ dysfunction. [Prothena Corporation plc] Press Release
CEL-SCI Expands Its Pivotal Phase III Immunotherapy Head and Neck Cancer Trial with Addition of Seven More Clinical Sites
CEL-SCI Corporation announced that it has added seven new clinical sites to its global pivotal Phase III head and neck cancer trial for its investigational immunotherapy Multikine. [CEL-SCI Corporation] Press Release
TxCell Announces Start of Phase IIb Clinical Trial with Ovasave® for Refractory Crohn’s Disease
TxCell SA announced that it has enrolled the first patient in its Phase IIb clinical trial of its lead product Ovasave® in refractory Crohn’s disease. [TxCell SA] Press Release
Juno Therapeutics Executes License for Phase I CAR T Product Candidate Targeting CD22 for Hematological Malignancies
Juno Therapeutics, Inc. announced that it has entered into an agreement to obtain a license from Opus Bio, Inc. for a CAR-T cell product candidate targeting CD22, a protein expressed on most B cell leukemias and lymphomas. [Juno Therapeutics, Inc.] Press Release
Alnylam Files Clinical Trial Application (CTA) for ALN-CC5, an RNAi Therapeutic Targeting Complement C5 in Development for the Treatment of Complement-Mediated Diseases
Alnylam Pharmaceuticals, Inc. announced that it has filed a CTA with the U.K. Medicines and Healthcare products Regulatory Agency to initiate a Phase I/II clinical trial with ALN-CC5, a subcutaneously administered investigational RNAi therapeutic targeting complement component C5 for the treatment of complement-mediated diseases. [Alnylam Pharmaceuticals, Inc.] Press Release
Pfizer Expands Rare Disease Research with Establishment of Gene Therapy Platform
Pfizer Inc. announced two strategic decisions to expand the company’s rare disease research and development activities through the establishment of a gene therapy platform to investigate potential treatments for patients. [Pfizer Inc.] Press Release
The Pacific Meso Center Receives $100,000 Donation for Ongoing Stem Cell Research Program
Citing the need to invest in a long-range cure, Roger Worthington of the Worthington & Caron, P.C. donated $100,000 to The Pacific Meso Center at The Pacific Heart, Lung & Blood Institute to support its ongoing stem cell research program. [The Pacific Heart, Lung & Blood Institute] Press Release
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