PUBLICATIONS (Ranked by Impact Factor of the Journal) |
Functional Engraftment of Colon Epithelium Expanded In Vitro from a Single Adult Lgr5+ Stem Cell Here investigators describe methods for long-term expansion of colonic stem cells positive for leucine-rich repeat containing G protein-coupled receptor 5 (Lgr5+ cells) in culture. To test the transplantability of these cells, the researchers reintroduced cultured GFP+ colon organoids into superficially damaged mouse colon. [Nat Med] Abstract
Transferred Melanoma-Specific CD8+ T Cells Persist, Mediate Tumor Regression, and Acquire Central Memory Phenotype As a means to enhance persistence of infused T cells in vivo and limit toxicity, 11 patients with refractory, progressive metastatic melanoma received cyclophosphamide alone as conditioning before the infusion of peripheral blood mononuclear cell-derived, antigen-specific, CD8+ cytotoxic T-lymphocyte clones followed by low-dose or high-dose IL-2. [Proc Natl Acad Sci USA] Abstract | Press Release
Improvement of Islet Function in a Bioartificial Pancreas by Enhanced Oxygen Supply and Growth Hormone Releasing Hormone Agonist Critical shortage of donor organs, gradual loss in graft function over time, and chronic need for immunosuppression limit the indication for islet transplantation to a small group of patients. Here researchers present a promising approach to address these limitations by utilization of a macrochamber specially engineered for islet transplantation. [Proc Natl Acad Sci USA] Abstract | Press Release
Scanning Probe-Enabled Nanocombinatorics Define the Relationship between Fibronectin Feature Size and Stem Cell Fate In a proof-of-concept investigation of mesenchymal stem cell (MSC) differentiation, combinatorial patterns first enabled a rapid and systematic screening of MSC adhesion, as a function of feature size, while uniform patterns were used to study differentiation with statistically significant sample sizes. [Proc Natl Acad Sci USA] Abstract | Press Release
The Cartilage Matrix Molecule Components Produced by Human Fetal Cartilage Rudiment Cells within Scaffolds and the Role of Exogenous Growth Factors This study examined the matrix components elaborated by cultured fetal cartilage rudiment cells, a mixture of chondroblasts/chondroprogenitor cells and committed chondrocytes, in monolayer, cell pellet cultures and in the synthetic scaffolds sodium alginate and polyglycolic acid. The ability of fibroblast growth factor (FGF)-2 and FGF-18 to promote chondrogenesis in pellet cultures was also examined. [Biomaterials] Abstract
Modulation of Mesenchymal Stem Cell Chondrogenesis in a Tunable Hyaluronic Acid Hydrogel Microenvironment In this study, hyaluronic acid-tyramine hydrogels were explored as biomimetic matrices for caprine mesenchymal stem cells in cartilage tissue engineering. [Biomaterials] Abstract
Functional Characterization of TPO-Expanded CD34+ Cord Blood Cells Identifies CD34–CD61– Cells as Platelet Producing Cells Early after Transplantation in NOD/SCID Mice and rCD34+ Cells as CAFC Colony Forming Cells It is unknown which sub-populations of TPO expanded cord blood CD34+ cells mediate accelerated platelet recovery and bone marrow (BM) engraftment. In this study, the contribution of these sub-populations to human platelet appearance in the blood and BM engraftment was studied in NOD/SCID mice. [Stem Cells] Abstract
Neonatal Gene Therapy with a Gamma Retroviral Vector in Mucopolysaccharidosis VI Cats Mucopolysaccharidosis VI cats were injected intravenously with a gamma retroviral vector (RV)-expressing feline N-acetylgalactosamine 4-sulfatase, resulting in 5 ± 3 copies of RV per 100 cells in liver. [Mol Ther] Abstract
Long-Term Correction of Very Long-Chain Acyl-CoA Dehydrogenase Deficiency in Mice Using AAV9 Gene Therapy Very long-chain acyl-coA dehydrogenase (VLCAD)-deficient mice were treated systemically with 1 × 1012 vector genomes of recombinant adeno-associated virus 9 (rAAV9)-VLCAD. [Mol Ther] Abstract
Therapeutic Angiogenesis due to Balanced Single-Vector Delivery of VEGF and PDGF-BB Researchers tested the hypothesis that codelivery of platelet-derived growth factor-BB (PDGF-BB) could induce normal angiogenesis in skeletal muscle irrespective of vascular endothelial growth factor (VEGF) levels. [FASEB J] Abstract | Press Release
Three-Dimensional Multipotent Progenitor Cell Aggregates for Expansion, Osteogenic Differentiation and ‘In Vivo’ Tracing with AAV Vector Serotype 6 In this study, researchers tested whether self-complementary adeno-associated viral vectors (AAV) can potentially be used as a gene delivery system in an osteogenically differentiated multipotent adult progenitor cell-based ‘in vivo’ bone formation model in the craniofacial region. [Gene Ther] Abstract
Chimerism and Tolerance without GVHD or Engraftment Syndrome in HLA-Mismatched Combined Kidney and Hematopoietic Stem Cell Transplantation Researchers developed an approach to induce immune tolerance for organ transplants using a bioengineered mobilized cellular product enriched for hematopoietic stem cells and tolerogenic graft facilitating cells combined with nonmyeloablative conditioning; this approach resulted in engraftment, durable chimerism, and tolerance induction in recipients with highly mismatched related and unrelated donors. [Sci Transl Med] Abstract | Press Release
Human Müller Glia with Stem Cell Characteristics Differentiate into Retinal Ganglion Cell (RGC) Precursors In Vitro and Partially Restore RGC Function In Vivo following Transplantation Researchers’ results suggest that transplanted RGC precursors may be capable of establishing local interneuron synapses and possibly release neurotrophic factors that facilitate recovery of RGC function. [Stem Cells Transl Med] Abstract | Press Release
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BUSINESS |
AACR Calls for Letters of Intent for a New Stand Up To Cancer-Cancer Research Institute Cancer Immunology Translational Research Dream Team Stand Up To Cancer (SU2C) and the Cancer Research Institute (CRI), along with the American Association for Cancer Research (AACR), call upon the cancer research community to submit Letters of Intent for a new Dream Team – the SU2C-CRI Cancer Immunology Translational Research Dream Team. [American Association for Cancer Research] Press Release
Pediatric Research Institute Launched by Children’s Medical Center, UT Southwestern Children’s Medical Center is partnering with the University of Texas (UT) Southwestern Medical Center to establish a unique $150 million venture that will bring together the finest scientists to pursue research with the potential to change scientific fields, as well as the way disease is treated in children and adults. [University of Texas Southwestern Medical Center] Press Release
Opexa Therapeutics Executes Strategic Service Agreement with Pharmaceutical Research Associates to Manage Clinical Trial Opexa Therapeutics, Inc. announced that the Company has executed an agreement with Pharmaceutical Research Associates, Inc. to provide contract research organization services to support Opexa’s upcoming Phase IIb clinical trial for Tovaxin, a novel T-cell therapy for multiple sclerosis (MS), in patients with secondary progressive MS. [Opexa Therapeutics, Inc.] Press Release
Medistem Signs Exclusive Worldwide License with Yale University for Treatment of Type 1 Diabetes Using Stem Cells Medistem Inc. and Yale University have signed an exclusive worldwide licensing agreement covering the generation of pancreatic islets from stem cells such as the Endometrial Regenerative Cell. [Medistem Inc.] Press Release
Student Innovation at Rensselaer Polytechnic Institute Seeks to Mend Previously Untreatable Tissue Injuries Christopher Rivet has successfully married two powerful bioengineering technologies to develop a new method for delivering drugs directly to an injury site and jumpstarting the process of tissue regeneration. Rivet is one of three finalists for the 2012 $30,000 Lemelson-MIT Rensselaer Student Prize. [Rensselaer Polytechnic Institute] Press Release
Bellicum Closes $20 Million Series B Financing Bellicum Pharmaceuticals, Inc. announced that it has raised $20 million in a Series B financing. The funding will be used to advance its lead CaspaCIDe™ and DeCIDe™ programs through Phase II clinical development. [Bellicum Pharmaceuticals, Inc.] Press Release
Medicyte and PRIMACYT Receive Grant to Develop Human Liver Cells for Cell-Based Therapies Medicyte and PRIMACYT have received a 300,000 Euro grant from the German Federal Ministry of Education and Research to develop culturing methods of hepatocytes for use in cell-based therapies. [Medicyte GmbH] Press Release
BrainStorm Cell Therapeutics Expands Pipeline with the Initiation of a Study for Multiple Sclerosis BrainStorm Cell Therapeutics Inc. announced plans to initiate a preclinical study assessing the efficacy of its NurOwn™ stem cell technology in patients with Multiple Sclerosis. [BrainStorm Cell Therapeutics Inc.] Press Release
Cartilage Repair Gel Gives Injuries a Sporting Chance A cartilage gel being developed by tissue engineers and biochemists could bring increased mobility to people living with debilitating sports injuries. [University of Sydney] Press Release
Medistem Inc. to Add Kidney and Lung Failure to Clinical Trials of Endometrial Regenerative Cells (ERC) Stem Cells in Russia Medistem Inc., in partnership with its Russian licensee, ERCell, announced the signing of a letter of intent to begin clinical trials using Medistem’s ERC stem cells for renal, lung and peripheral artery disease. [Medistem Inc.] Press Release
Intellect Neurosciences Receives Notice of Allowance from United States Patent and Trademark Office for its ANTISENILIN® Alzheimer’s Disease Immunotherapy Technology Platform Intellect Neurosciences, Inc. announced that it received a Notice of Allowance from the United States Patent and Trademark Office for patent claims covering the company’s ANTISENILIN® monoclonal antibody platform technology for the treatment and prevention of Alzheimer’s disease. [Intellect Neurosciences, Inc.] Press Release
American Society of Hematology Announces 2012 Translational Research Training in Hematology Program Participants The American Society of Hematology and the European Hematology Association announce the names of 20 early-career hematologists chosen to participate in the 2012 Translational Research Training in Hematology joint program. [American Society of Hematology] Press Release |
JOB OPPORTUNITIES |
Scientist – Pluripotent Stem Cells (STEMCELL Technologies, Inc.)
Scientist – hPSC Bioengineering (STEMCELL Technologies, Inc.)
Scientist – Antibody and Hybridoma Technology Platforms (STEMCELL Technologies, Inc.)
Business Analyst – Product Management (STEMSOFT Software, Inc.)
Senior Development Associate (Genzyme Corporation)
Scientist II, Innovation – Cell Processing Technologies (Lonza Walkersville, Inc.)
Senior Manager, Innovation – Cell Processing Technologies (Lonza Walkersville, Inc.)
Postdoctoral Fellow and Technician Positions (North Carolina Central University)
Quality Assurance Manager, GMP (Cellular Dynamics International)
Research Technologist III (Medical College of Wisconsin)
Postdoctoral Position: Manager/Chair in the Beta- Cell Biology and Therapy Unit (Kocaeli University)
Postdoctoral Position in Stem Cell Biology/Neuroscience/Cancer (The Jackson Laboratory)
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