|
SCIENCE NEWS
Rare Genetic Variations Involving Whole Sections of DNA Implicated in Autism Losses and duplications of whole chunks of DNA at sites across our genomes are likely to play a role in autism spectrum disorders, suggests a new international study. [Press release from the Wellcome Trust Centre for Human Genetics discussing online prepublication in Nature]
Down's Syndrome Chromosome Yields More Cancer-Blocking Genes Scientists have discovered cancer-blocking activity for genes carried on chromosome 21 — an extra copy of which is carried by people with Down’s syndrome. [Press release from Cancer Research UK discussing online prepublication in Nature]
Researchers Discover How Mutations in Presenilin Gene Cause Early-Onset Alzheimer's Disease Researchers have discovered how mutations in the presenilin 1 gene cause early-onset Alzheimer's disease. [Press release from New York University Langone Medical Center discussing online prepublication in Cell]
Scientists’ Finding of an Ancient Viral Invasion that Shaped the Human Genome an Important Step Towards Advancement in Regenerative Medicine Scientists have discovered that viruses that ‘invaded’ the human genome millions of years ago have changed the way genes get turned on and off in human embryonic stem cells. [Press release from the Genome Institute of Singapore discussing online prepublication in Nature Genetics]
Gene Swaps May Make Cancers Vulnerable Researchers have identified a set of hybrid genes that may accelerate the growth of prostate cancer, gastric cancer, and melanoma. [Press release from Howard Hughes Medical Institute discussing online prepublication in Nature Medicine]
Scientists Take First Steps in Growing Working Livers Scientists have created working liver grafts in the lab, and say the research could one day allow the growth of livers for transplant. [Press release from BBC Science News discussing online prepublication in Nature Medicine]
Reprogramming Immune System Cells to Produce Natural Killer Cells for Cancer Researchers produced a new type of cell by knocking out a single gene essential in the pathways of development of immune cells: the modified cells become a novel type, which the authors call Induced T to Natural Killer Cells. [Press release from the Wellcome Trust Sanger Institute discussing online prepublication in Science]
Novel 'Cell Wires' to Patch up Heart or Nerve Damage Researchers have discovered a way to align huge arrays of nano-sized filaments and living cells over macroscopic distances. [Press release from the Royal Society of Chemistry discussing online prepublication in Nature Materials]
Researchers Discover Mechanism that Limits Scar Formation Researchers have discovered that an unexpected cellular response plays an important role in breaking down and inhibiting the formation of excess scar tissue in wound healing. [Press release from the University of Illinois at Chicago discussing online prepublication in Nature Cell Biology]
New Type of Human Stem Cell May Be Easier to Manipulate Researchers have developed a new type of human pluripotent stem cell that can be manipulated more readily than currently available stem cells. [Press release from the Massachusetts General Hospital Center for Regenerative Medicine discussing online prepublication in Cell Stem Cell]
Ironing Out Inflammation: Substance in Iron Metabolism Displays Life-Saving Potential In a surprising discovery that someday may lead to new treatments for many inflammatory diseases, scientists found that a hormone involved in iron metabolism can save mice from deadly acute inflammation. [Press release from the University of Utah discussing online prepublication in the Journal of Clinical Investigation]
How the Wrong Genes Are Repressed The mechanism by which ‘polycomb’ proteins critical for embryonic stem cell function and fate are targeted to DNA has been identified by scientists. [Press release from University College London discussing online prepublication in Molecular Cell]
Obstacles to Stem Cell Therapy Cleared Researchers have come up with a new technique to prevent tumors developing in connection with stem cell transplantations. [Press release from Lund University discussing online prepublication in the Proceedings of the National Academy of Sciences USA]
Mount Sinai Researchers Approaching Universal Treatment for All Strains of Influenza Researchers have, for the first time, identified a small-viral RNA, derived from the influenza virus, that is integral to the switch from transcription to replication. [Press release from the Mount Sinai School of Medicine discussing online prepublication in the Proceedings of the National Academy of Sciences USA]
Gene Related to Aging Plays Role in Stem Cell Differentiation A gene shown to play a role in the aging process appears to play a role in the regulation of the differentiation of embryonic stem cells. [Press release from Thomas Jefferson University Hospital discussing online prepublication in Aging Cell]
Researchers Find Way to Prevent Blindness in Research Model for Retinitis Pigmentosa Researchers have found a way to use a radical new type of gene therapy to prevent blindness caused by retinitis pigmentosa. [Press release from The University of Oklahoma Health Sciences Center discussing online prepublication in the Journal of the Federation of American Societies for Experimental Biology]
Innovative University of Virginia Technology Could Make Fat the Cure for What Ails You New technology involving adipose stem cells could one day be used to treat patients with severe wounds and other serious conditions. [Press release from the University of Virginia discussing online prepublication in Tissue Engineering, Part A]
New Therapy Offers Hope to Spinal Muscular Atrophy (SMA) Patients Research has shown that a novel gene transfer system has the potential to provide an effective therapeutic treatment for SMA patients. [Press release from the University of Sheffield discussing online prepublication in Science Translational Medicine]
Tissue Regeneration Research Could Help Keep Seniors Active A researcher is currently trying to develop microscopic polymer fibers to help rebuild human tissue and speed the healing process. [Press release from Queen's University discussing research presented at the Advanced Foods and Materials Network 6th Annual Conference]
Argos Therapeutics Presents Positive Phase II Data for Arcelis™ Dendritic Cell-based Immunotherapy in Advanced RCC Argos Therapeutics announced the presentation of positive interim data from a Phase II trial that evaluated the clinical activity, safety and immune response of AGS-003 treatment, given in combination with sunitinib, in patients with newly diagnosed advanced renal cell carcinoma (RCC). [Press release from Argos Therapeutics, Inc. discussing research presented at the 46th Annual Meeting of the American Society of Clinical Oncology]
Reduced-Dose Velcade-Thalidomide-Dexamethasone Combination Shows Promise as Initial Therapy Prior to Stem Cell Transplantation The combination treatment of reduced-dose Velcade (bortezomib), thalidomide (Thalomid), and dexamethasone (Decadron), abbreviated vTD, appears to be a safe and effective induction treatment for newly diagnosed multiple myeloma patients prior to stem cell transplantation. [Press release from the Myeloma Beacon discussing research presented at the 46th Annual Meeting of the American Society of Clinical Oncology]
Oxford BioMedica Announces Two-Year Phase I/II Results of ProSavin® In Parkinson's Disease Oxford BioMedica announced new data from the ongoing Phase I/II trial of ProSavin®, its novel gene therapy for the treatment of Parkinson’s disease. [Press release from Oxford Biomedica plc discussing research presented at the 9th Annual Congress of the French Society of Cell and Gene Therapy]
CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)
Patient-Specific Induced Pluripotent Stem-Cell-Derived Models of LEOPARD Syndrome Researchers show that in vitro-derived cardiomyocytes from LEOPARD syndrome induced pluripotent stem cells (iPSCs) are larger, have a higher degree of sarcomeric organization and preferential localization of NFATC4 in the nucleus when compared with cardiomyocytes derived from human embryonic stem cells or wild-type iPSCs derived from a healthy brother of one of the LEOPARD syndrome patients. [Nature]
Functional Impact of Global Rare Copy Number Variation in Autism Spectrum Disorders Results reveal many new genetic and functional targets in autism spectrum disorders that may lead to final connected pathways. [Nature]
Tumor Angiogenesis Is Reduced in the Tc1 Mouse Model of Down’s Syndrome Researchers expect that, in addition to the candidate genes that they show to be involved in the repression of angiogenesis, the Tc1 mouse model of Down’s syndrome will permit the identification of other endothelium-specific anti-angiogenic targets relevant to a broad spectrum of cancer patients. [Nature]
Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations Researchers show that macroautophagy, a lysosomal degradative pathway essential for neuron survival, requires the Alzheimer's disease-related protein presenilin-1. [Cell]
Transposable Elements Have Rewired the Core Regulatory Network of Human Embryonic Stem Cells Data indicate that species-specific transposable elements have substantially altered the transcriptional circuitry of pluripotent stem cells. [Nat Genet]
Rearrangements of the RAF Kinase Pathway in Prostate Cancer, Gastric Cancer and Melanoma Results emphasize the key role of RAF family gene rearrangements in cancer, suggest that RAF and MEK inhibitors may be useful in a subset of gene fusion–harboring solid tumors and demonstrate that sequencing of tumor transcriptomes and genomes may lead to the identification of rare targetable fusions across cancer types. [Nat Med]
Organ Reengineering Through Development of a Transplantable Recellularized Liver Graft Using Decellularized Liver Matrix Results provide a proof of principle for the generation of a transplantable liver graft as a potential treatment for liver disease. [Nat Med]
Reprogramming of T Cells to Natural Killer-Like Cells upon Bcl11b Deletion Researchers show that the transcription factor Bcl11b was expressed in all T cell compartments and was indispensable for T-lineage development. When Bcl11b was deleted, T cells from all developmental stages acquired NK cell properties and concomitantly lost or decreased T cell-associated gene expression. [Science]
A Self-Assembly Pathway to Aligned Monodomain Gels The nature of the self-assembly process and its biocompatibility would allow formation of cellular wires in situ that have any length and customized peptide compositions for use in biological applications. [Nat Mater]
The Matricellular Protein CCN1 Induces Fibroblast Senescence and Restricts Fibrosis in Cutaneous Wound Healing Researchers show that the matricellular protein CCN1, which is dynamically expressed at sites of wound repair, can induce fibroblast senescence by binding to integrin alpha6beta1 and the heparan sulphate proteoglycans. [Nat Cell Biol]
A Murine ESC-Like State Facilitates Transgenesis and Homologous Recombination in Human Pluripotent Stem Cells Researchers demonstrate that human induced pluripotent stem cell reprogramming in the presence of LIF yields human stem cells that display morphological, molecular, and functional properties of murine embryonic stem cells (ESCs). [Cell Stem Cell]

|
|
|
BUSINESS
Cellectis Bioresearch and Lonza Enter Development and Commercial Manufacturing Agreement Cellectis Bioresearch and Lonza announced that the companies have entered into an agreement for the development and commercialization of a bioengineered cell line. [Cellectis Bioresearch Press Release]
Lonza Announces Worldwide, Exclusive Licensing and Supply Agreements with California Stem Cell Inc. Lonza Inc. has entered worldwide, exclusive licensing and supply agreements with California Stem Cell Inc. This collaboration makes novel pluripotent stem cell products readily available to researchers worldwide. [Lonza, Inc. Press Release]
Connecticut Awards $9.8 Million in Stem Cell Research Grants Connecticut state has awarded $9.8 million in grants to support nearly two dozen stem cell research projects by scientists at the University of Connecticut and at Yale. [State of Connecticut Press Release]
ISSCR Launches Web Site Providing Information on Stem Cell Treatments The International Society for Stem Cell Research (ISSCR) announced that it has launched “A Closer Look at Stem Cell Treatments” (www.closerlookatstemcells.org), a web site to arm patients, their families and doctors with information they need to make decisions about stem cell treatments. [International Society for Stem Cell Research Press Release]
International Stem Cell Corporation’s Parthenogenetic Stem Cell Patent is Approved by the United States Patent and Trademark Office International Stem Cell Corporation announced that the United States Patent and Trademark Office has granted ISCO patent number 7,732,202, the first of several pending patents relating to its development of human parthenogenetic stem cells. [International Stem Cell Corporation Press Release]
NIH Approves Advanced Cell Technology's Stem Cell Line for Federal Funding Advanced Cell Technology, Inc. announced that human embryonic stem cell line MA135 was unanimously approved for federal funding at the 100th Meeting of the Advisory Committee to the Director National Institutes of Health (NIH). [Advanced Cell Technology, Inc. Press Release]
Human Genome Sciences Announces Submission of Biologics License Application to FDA for Benlysta® (Belimumab) Human Genome Sciences, Inc. announced that it has submitted a Biologics License Application to the U.S. Food and Drug Administration for approval to market BENLYSTA® (belimumab) for the treatment of systemic lupus erythematosus. [Human Genome Sciences, Inc. Press Release]
Faster Treatment of Heart Patients with a Finger Prick of Blood: New Bedside Tool to Detect Rare Endothelial Progenitor Cells From sample to answer in just one hour with just a finger prick of blood is what researchers aim to achieve with their novel microfluidic system for rapid and sensitive detection of rare circulating endothelial progenitor cells. [A*STAR Institute of Microelectronics Press Release]
Stem Cell Therapeutics Corp. Announces the Issuance of United States Patent Stem Cell Therapeutics Corp. announced that it has been granted U.S. Patent 7,704,737 entitled, “Oligodendrocyte Production from Multipotent Neural Stem Cells.” [Stem Cell Therapeutics Corp. Press Release]
|
|
|
|
|
EVENTS
SPECIAL FEATURE
ImVacS brings together international vaccine leaders to discuss challenges and current breakthroughs in the world of vaccines. The four vaccine-focused meetings address innovating strategies to meet current health threats, changing technology for vaccine manufacture, top challenges faced during pre-clinical development, and progress underway for adjuvants and novel delivery systems.
CHI's 5th Annual Immunotherapeutics and Vaccine Summit (ImVacS) August 17-19, 2010 Cambridge, United States |
|
International Society for Stem Cell Research (ISSCR) 8th Annual Meeting June 16-19, 2010 San Francisco, United States
Accelerating Anticancer Agent Development and Validation June 23-25, 2010 North Bethesda, United States
XXXIst International Congress of the International Society of Blood Transfusion (ISBT) in joint cooperation with the 43rd Congress of the German Society for Transfusion Medicine and Immunohematology (DGTI) June 26-July 1, 2010 Berlin, Germany
Worldwide Innovative Networking (WIN) Symposium in Personalized Cancer Medicine July 7-9, 2010 Paris, France
Translational Cancer Medicine 2010 – USA July 11-14, 2010 San Francisco, United States
United Kingdom National Stem Cell Network (UKNSCN) Annual Scientific Conference July 12-14, 2010 Nottingham, United Kingdom
2nd International Conference on Cellular and Molecular Bioengineering (ICCMB2) August 2-4, 2010 Singapore City, Singapore
CHI's 5th Annual Immunotherapeutics and Vaccine Summit (ImVacS) August 17-19, 2010 Cambridge, United States
Select Biosciences 3rd Annual Stem Cells Europe Conference August 24-25, 2010 Edinburgh, Scotland
Select Biosciences 2nd Annual World Biobanking Summit August 24-25, 2010 Edinburgh, Scotland
Select Biosciences Inaugural Cellular Therapy Summit August 24-25, 2010 Edinburgh, Scotland
International Society for Cellular Therapy (ISCT) – Europe 2nd Regional Meeting September 11-14, 2010 Belgirate, Italy
Hydra VI: The European Summer School on Stem Cells & Regenerative Medicine September 11-17, 2010 Hydra, Greece
Joint Metastasis Research Society – American Association of Cancer Research Conference on Metastasis and the Tumor Microenvironment September 12-15, 2010 Philadelphia, United States
Stem Cells USA & Regenerative Medicine Congress 2010 September 13-15, 2010 Philadelphia, United States
Select Biosciences 7th Annual RNAi & miRNA Europe September 14-15, 2010 Dublin, Ireland
Select Biosciences Inaugural Epigenetics Europe Conference September 14-15, 2010 Dublin, Ireland
Select Biosciences Inaugural Genomics Automation Europe Conference September 14-15, 2010 Dublin, Ireland
Tissue Engineering & Regenerative Medicine International Society (TERMIS) – Asia Pacific 2010 September 15-17, 2010 Sydney, Australia
4th American Association of Cancer Research International Conference on Molecular Diagnostics in Cancer Therapeutic Development September 27-30, 2010 Denver, United States
Select Biosciences 6th Annual Ion Channel Targets Conference September 28-29, 2010 Washington, DC, United States
2010 World Stem Cell Summit October 4-6, 2010 Detroit, United States
5th World Congress on Preventive & Regenerative Medicine (WCRM) October 5-7, 2010 Hannover, Germany
American Association of Blood Banks (AABB) Annual Meeting & Cellular Therapy and Transfusion Medicine Expo (CTTXPO) 2010 October 9-12, 2010 Baltimore, United States
Translational Cancer Research for Basic Scientists October 17-22, 2010 Boston, United States
3rd Annual Dubai Congress on Anti-Aging and Aesthetic Medicine (DCAAAM) October 26-27, 2010 Dubai, United Arab Emirates
World Stem Cells & Regenerative Medicine Congress Asia 2010 October 26-29, 2010 Singapore City, Singapore
Select Biosciences 3rd Annual Molecular Diagnostics World Congress October 28-29, 2010 San Diego, United States
Fraunhofer Life Science Symposium 2010 October 29-30, 2010 Leipzig, Germany
Stem Cell Society Singapore Symposium 2010: Translating Science to Therapy November 2-3, 2010 Singapore City, Singapore
Select Biosciences 5th Annual European Biomarkers Summit November 9-10, 2010 Florence, Italy
Select Biosciences International Forum on Stem Cells November 12-13, 2010 Tianjin, China
Select Biosciences 2nd Annual RNAi Asia Conference November 15-16, 2010 Singapore City, Singapore
Stem Cell Network 10th Annual Scientific Meeting November 22-24, 2010 Calgary, Canada
Tissue Engineering & Regenerative Medicine International Society (TERMIS) – North America 2010 Annual Conference December 5-8, 2010 Orlando, United States
Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.
JOB OPPORTUNITIES
Senior Scientist – Magnetic Cell Separation (STEMCELL Technologies)
Business Development Manager Europe – Cell Therapy Products (Pall Corporation)
Manager/Sr. Manager, Therapeutic Cell Solutions, Process Development (Lonza)
Sr. Product Support and Training Specialist (CardianBCT)
Recruit Top Talent Reach more than 11,000 potential candidates by posting your organization's career opportunities with Cell Therapy News. Visit here to post your career opportunities.
|
|
|