Volume 10.22 | Jun 15

Cell Therapy News 10.22, June 15, 2009
     In this issue: Science | Policy | Business | NIH | CBER | Regulatory
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Top Stories

Advanced Cell Technology and Collaborators at The Casey Eye Institute Present Promising Data Supporting Safety and Efficacy of Stem Cell Therapy to Combat Retinal Disease: The research shows long-term functional rescue using hESC-derived cells in both the RCS rat and Elov14 mouse, animal models of retinal degeneration and Stargardt.


Complimentary Wallchart: Guide to Hematopoietic Colonies Derived from Human Cord Blood Progenitors
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International Stem Cell Collaboration Results in Discovery of Promising New Stem Cell Type
Researchers have announced the discovery of a previously unidentified stem cell population from adult human testis.

Stem Cell Protein Offers a New Cancer Target
A protein abundant in embryonic stem cells is now shown to be important in cancer, and offers a possible new target for drug development.

Hundreds of Cell-surface Proteins Can Be Simultaneously Studied with New Technique
The results obtained could help to develop more accurate diagnostic tests and more specific therapies in the future.

Gene Therapy for Hemophilia A Mice
Researchers have now developed a new approach to target genes specifically to mouse liver sinusoidal endothelial cells and used it to provide long-term expression of Factor VIII in hemophilia A mice, markedly reducing their disease.

MicroRNA Replacement Therapy May Stop Cancer in Its Tracks
Scientists at Johns Hopkins have discovered a potential strategy, by delivering microRNAs to cancer cells, could help to stop the disease in its tracks.

Trimming the Fat Boosts Blood Recovery After Marrow Transplant
Seeking ways to improve blood recovery after chemotherapy or bone marrow transplant, researchers have discovered that fat cells, which accumulate in bone marrow as people age, inhibit the marrow’s ability to produce new blood cells.

Landmark Stem Cells Trial Yields Positive Results
The Phase I trial of HuCNS-SC (purified human neural stem cells) conducted at OHSU Doernbecher Children’s Hospital included six children with advanced stages of infantile and late-infantile neuronal ceroid lipofuscinosis, often referred to as Batten disease.

Alnylam and Cubist Report Preliminary Data from Phase II Study of ALN-RSV01 in Lung Transplant Patients Naturally Infected with Respiratory Syncytial Virus
Alnylam Pharmaceuticals recently reported preliminary data from their Phase II study of ALN-RSV01, an RNAi therapeutic in development for the treatment of respiratory syncytial virus infection.


Genotoxic Stress Abrogates Renewal of Melanocyte Stem Cells by Triggering Their Differentiation
This study report that irreparable DNA damage, as caused by ionizing radiation, abrogates renewal of MSCs in mice. (Cell)

Despite Odds, Cities Race to Bet on Biotech
At a recent global biotech convention in Atlanta, 27 states, including Hawaii and Oklahoma, paid as much as $100,000 each to entice companies on the exhibition floor. All this for a highly risky industry that has turned a profit only one year in the past four decades.

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Bob Klein to Leave CIRM Chairman Job
Bob Klein, the architect of California’s $3 billion stem cell research funding program, will not seek a new term as chairman of the agency.


Connexon Creative Launches Mammary Cell News
Mammary Cell News is a weekly e-newsletter that keeps members of the mammary cell community informed by providing the latest news from all areas of the field, including its science, research and business.

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Amarna Therapeutics B.V. and TNO Announce SVac Research and Development Partnership
Dutch biotechnology company Amarna Therapeutics B.V. and the Netherlands Organization for Applied Scientific Research TNO recently announced that they have entered into a collaboration agreement to further develop Amarna’s viral gene delivery platform SVac.

ReNeuron Signs Manufacturing Contract to Provide Stem Cells for Stroke Clinical Trial
ReNeuron Group plc recently announced that it has signed a contract with Angel Biotechnology Holdings plc, under which Angel will manufacture clinical-grade ReN001 stem cell lots for ReNeuron’s Phase I clinical trial with its ReN001 therapy in disabled stroke patients.

Bayhill Therapeutics Enters Exclusive, Worldwide Collaboration with Genentech for BHT-3021 in Type 1 Diabetes
Bayhill Therapeutics Inc. announced recently that it has entered into a license agreement for the development and commercialization of BHT-3021 with Genentech, Inc, a DNA based antigen specific immunotherapy currently in a phase I/II clinical trial in patients with type 1 diabetes.

ThermoGenesis Nabs NIH Grant for Stem Cell Delivery
ThermoGenesis Corp. said recently it has received a grant from the National Institute of Health to study and develop biomaterials that can be used to deploy placental stem cells in bone repair and regenerative medicine applications.

Vitro Receives Adult Stem Cell Patent from the United States Patent and Trademark Office
Vitro Diagnostics, Inc., dba Vitro Biopharma, announced that it has been awarded United States Patent number 7,527,971 entitled, “Generation and Differentiation of Adult Stem Cells.”


NIH Receives 20,000 Applications for Challenge Grants Through the Recovery Act
This large number of applications is approximately equal to the total number of applications NIH receives in one of the agency’s three major review rounds each year.

Announcing New Business Processes and Confirming the Transition of Individual National Research Service Award (NRSA) Fellowship (F) Applications to Electronic Submission (NOT-OD-09-106)


Launch of New FDA Website Makes Some Older Links Nonfunctional
The FDA’s recently announced overhaul of its website took effect last week, and the immediate result was a short-term increase in inconvenience as users scrambled to find web page addresses that had changed.



WEBINAR: Inside the FDA’s New Office in China: Exclusive Report From Beijing
June  18,  2009 | 9:30-11:00 EDT

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