Researchers Uncover Stem Cell Pathway
Researchers at the Keck School of Medicine of USC have identified a signaling pathway that helps regulate the movement of blood-forming stem cells in the body.
Making Gene Therapy Safer Using Self-inactivating LTRs
By analyzing specific elements of gamma-RVs and another type of viral vector, LVs, in a tumor-prone mouse model, a team of researchers have now provided evidence that LVs are substantially less likely to cause insertional mutagenesis and tumors than gamma-RVs.
Researchers Identify Growth Factor that Stimulates Adult Stem Cells
Researchers have identified for the first time a critical growth factor that stimulates the stem cells that produce sperm to thrive and renew themselves.
Researchers Decipher Blood Stem Cell Attachment, Communication
Researchers at the National Institutes of Health have deciphered a key sequence of events governing whether the stem cells that produce red and white blood cells remain anchored to the bone marrow, or migrate into the circulatory system.
Georgetown University Medical Center Researchers Show Adult Human Testes Cells Can Become Embryonic Stem-like, Capable of Treating Disease
Using what they say is a relatively simple method; scientists at Georgetown University Medical Center have extracted stem/progenitor cells from adult testes and have converted them back into pluripotent embryonic-like stem cells.
First Automated Carbohydrate ‘Assembly Line’ Opens Door to New Field Of Medicine
Scientists from Germany recently reported the development of an automated carbohydrate synthesizer, a device that builds these intricate molecules in a few hours — rather than the months or years required with existing technology.
British Scientists ‘To Create Synthetic Blood from Embryonic Stem Cells’
A major research project is to be announced this week that will culminate in three years with the first transfusions into human volunteers of “synthetic” blood made from the stem cells of spare IVF embryos.
New Stem Cell Therapy May Lead To Treatment for Deafness
A new study from the University of Sheffield has successfully isolated human auditory stem cells from fetal cochleae (the auditory portion of the inner ear) and found they had the capacity to differentiate into sensory hair cells and neurons.
Stem Cell Infusion and Hyperbaric Oxygen Treatment Improve Islet Function in Diabetes
A study to determine if patients with type 2 diabetes can benefit from a combination of autologous stem cell infusions and hyperbaric oxygen treatment before and after ASC has found “significant benefits” in terms of “improvements in glycemic control” along with “reduced insulin requirements.”
Research Identifies Genetic ‘Master Regulator’ in Skin Formation
Researchers at Oregon State University have found one gene in the human body that appears to be a master regulator for skin development.
The French Institute I-Stem Realizes First Innovative Screens Using Stem Cells to Identify Drugs for Myotonic Dystrophy, DM1 Disease
Four research teams of I-STEM[*] have joined forces in a collaborative project that has just achieved a first pilot therapy-oriented screen of compounds and RNA interference aiming at reversing the altered phenotypes observed in human embryonic stem cells carrying the mutant gene for myotonic dystrophy type1.
Therapeutic Cloning Gets a Boost with New Research Findings
A recent paper offers the first direct demonstration that cloning does not lead to an increase in the frequency of point mutations.
Bone Marrow Stem Cells do not Help Regenerate Heart Muscle Tissue, Contradicting Earlier Study
Researchers at the University of Washington School of Medicine have found that bone marrow stem cells do not convert into heart muscle cells in mice, contradicting a study that had prompted human clinical trials for such stem cell therapy in the treatment of heart attack.
Genetic Technique Successfully Treats Duchenne Muscular Dystrophy in Dogs
Using a novel technique called exon skipping to restore partial function to the gene; researchers have successfully treated dogs with the canine form of Duchenne muscular dystrophy.
Osiris Discontinues Enrollment in Crohn’s Study Due to Concerns with Trial Design
Osiris Therapeutics, Inc. announced recently that it has elected to end enrollment at 210 patients in its Phase III trial evaluating Prochymal for Crohn’s disease, due to a trial design flaw.
ABSTRACTS, REVIEWS AND SPECIAL REPORTS
Endogenous Bone Morphogenetic Proteins in Human Bone Marrow-derived Multipotent Mesenchymal Stromal Cells
In this study, the researchers address the possible role of endogenous osteogenic bone morphogenetic proteins in in situ osteoblastic differentiation of human mesenchymal stromal cells.
SWI/SNF-Brg1 Regulates Self-Renewal and Occupies Core Pluripotency-Related Genes in Embryonic Stem Cells
Here the researchers report that Brg1 is required for embryonic stem cell self-renewal and pluripotency.
JAMA Demands Silence from Those Who Find Conflicts Among Its Authors
The Journal of the American Medical Association has instituted a bizarre new policy requiring silence from anyone who notices a conflict of interest among its authors.
The World’s First ‘Ice Baby’ Grows Up
It is twenty five years ago that the first baby from a frozen embryo came into the world.
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