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Cell Therapy News is an online resource dedicated to sharing the latest cell therapy, gene therapy, and regenerative medicine research.
Single-Cell Sequencing Reveals VEGFR as a Potential Target for CAR-T Cell Therapy in Chordoma
[Journal Of Orthopaedic Translation] 14 chordoma samples from patients attending Xuanwu Hospital Capital Medical University were subjected to single-cell RNA sequencing. Target molecules were identified on chordoma cells and cancer metastasis-related signaling pathways characterised.
French-Canadian Gets ‘Oscars Of Science’ Prize For Cancer Treatment
[Barron's] French-Canadian scientist Michel Sadelain was awarded an "Oscars of Science" prize in Los Angeles for his research into genetically modifying immune cells to fight cancer.
Self-Adjuvanting Polymeric Nanovaccines Enhance IFN Production and Cytotoxic T Cell Response
[Journal Of Controlled Release] The authors reported a novel subunit vaccine delivery platform constructed via in situ free radical polymerization of C7A (2-(Hexamethyleneimino) ethyl methacrylate) and acrylamide around the surface of individual protein antigens.
Role of FoxP3+ Regulatory T Cells in Modulating Immune Responses to Adeno-Associated Virus Gene Therapy
[Human Gene Therapy] Regulatory T cells are crucial for maintaining tolerance against self or nonself antigens. Of importance, Tregs also play an important role in dampening immune responses to AAV gene therapy, including tolerance induction to the transgene product.
From Spear to Trident: Upgrading Arsenal of CAR-T Cells in the Treatment of Multiple Myeloma.
[Heliyon] The authors provide an overview of the new advances of CAR-T cells in the cure of multiple myeloma (MM), so in this review we looked at the progress of the clinical use of CAR-T cells in MM to try to provide a reference for their clinical use when managing MM.
A Novel Engineered IL-21 Receptor Arms T-Cell Receptor-Engineered T Cells (TCR-T Cells) Against Hepatocellular Carcinoma
[Signal Transduction And Targeted Therapy] Researchers determined the combination effects of IL-21 in T cell therapy against HCC and investigate optimized strategies to utilize the effect of IL-21 signal in T cell therapy.
USP8-Governed GPX4 Homeostasis Orchestrates Ferroptosis and Cancer Immunotherapy
[Proceedings Of The National Academy Of Sciences Of The United States Of America] Investigators reported that homozygous deletion of ubiquitin-specific protease 8 (Usp8) in intestinal epithelial cells (IEC) led to architectural changes in the colonic epithelium and shortens mouse lifespan accompanied by increased IEC death and signs of lipid peroxidation.
Bispecific CAR T Cell Therapy Targeting BCMA and CD19 in Relapsed/Refractory Multiple Myeloma: A Phase I/II Trial
[Nature Communications] Scientists designed bispecific BC19 CAR T cells targeting BCMA/CD19 and evaluated antimyeloma activity in vitro and in vivo. Preclinical results indicated that BC19 CAR specifically recognized target antigens, and BC19 CAR T cells mediate selective killing of BCMA or CD19-positive cancer cells.
Oncolytic Herpes Simplex Virus Expressing IL-2 Controls Glioblastoma Growth and Improves Survival
[Journal For Immunotherapy Of Cancer] The authors developed G47Δ-mIL2 using the flip-flop herpes simplex virus BAC system to deliver IL-2 locally within the tumor microenvironment (TME). They then tested its efficacy in orthotopic mouse GBM models and evaluated immune profiles in the treated tumors and spleens by flow cytometry and immunohistochemistry.
Monash Cord Blood Cell Therapy Research Recognised with Multiple Awards
[Monash University] Congratulations to Dr. Lindsay Zhou on receiving the Perinatal Research Society Mont Liggins Award and the Cerebral Palsy Alliance Award from the Perinatal Society of Australia and New Zealand for his research on cord blood cell therapy.
Cellular Trojan Horse Initiates Bimetallic Fe-Cu MOF-Mediated Synergistic Cuproptosis and Ferroptosis Against Malignancies
[Science Advances] Investigators engineered a Cellular Trojan Horse, named MetaCell, which used live neutrophils to stably internalize thermosensitive liposomal bimetallic Fe-Cu MOFs. MetaCell could instigate cuproptosis and ferroptosis, thereby enhancing treatment efficacy.
Characterization of a Novel T Cell-Engaging Bispecific Antibody for Elimination of L1CAM-Positive Tumors
[Biomedicine & Pharmacotherapy] Scientists designed and characterized a novel bispecific antibody based on the IgG-(L)-ScFv format, which targeted L1CAM and CD3 simultaneously.
Published since 2002, Cell Therapy News is our longest running online publication. Our editorial team curates the top publications, reviews, and news on in vivo gene therapy, cell therapy, and immunotherapy research. With over 15,000 subscribers and followers across our website, email newsletter, and Twitter feed, we are proud to facilitate the communication of cutting-edge cell therapy innovations.
