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A Novel Human Stem Cell-Based Model of ALS Opens Doors for Rapid Drug Screening
Researchers from the Salk Institute for Biological Studies for the very first time established a human embryonic stem cell-based system for modeling ALS.
Next Generation RNAi Technology Discovered by AiRNA Pharmaceuticals and Boston Biomedical
Research from this study highlights that the smaller 15 bp aiRNA can target a variety of genes with superior efficiency than the standard 19-21 bp siRNA and can target genes more selectively with significantly less off-target effects than the standard 19-21 bp siRNA.
New ‘Control Knobs’ for Stem Cells: Changes in Membrane Voltage Control Timing of Differentiation
Natural changes in voltage that occur across the membrane of adult human stem cells are a powerful controlling factor in the process by which these stem cells differentiate, according to research published by Tufts University scientists.
Dormant Stem Cells for Emergencies
A small group of stem cells in the bone marrow remains dormant almost throughout life and only in case of injury or blood loss do they awaken and become active.
Bone Marrow-Derived Stem Cells May Offer Novel Therapeutic Option for Skin Disorder
Stem cells derived from bone marrow may serve as a novel therapeutic option to treat a disease called epidermolysis bullosa, a disorder characterized by extraordinarily fragile skin.
Regulus Therapeutics, Alnylam Pharmaceuticals, and Collaborators Publish First Ever In Vivo Efficacy Data for a microRNA Therapeutic in a Disease Model
Regulus Therapeutics LLC, a joint venture between Alnylam Pharmaceuticals, Inc. and Isis Pharmaceuticals, Inc. announced recently the publication of new research in the journal Nature on the role of a microRNA, known as miR-21, in heart failure.
First Ever Treatment of Stroke Patient with Stem Cell Therapy Product
The International Neuroscience Institute is pleased to announce that the first patient has been treated in the first ever clinical trial for the treatment of stroke with a stem cell product.
ABSTRACTS, REVIEWS AND SPECIAL REPORTS
Human Embryonic Stem Cell-Derived Motor Neurons Are Sensitive to the Toxic Effect of Glial Cells Carrying an ALS-Causing Mutation
The researchers ask whether specific neuronal subtypes produced from human embryonic stem cells can be used to investigate the mechanisms leading to neural degeneration in amyotrophic lateral sclerosis.
Gene Therapy Using TRAIL-Secreting Human Umbilical Cord Blood–Derived Mesenchymal Stem Cells against Intracranial Glioma
In the present study, the researchers evaluated the tumor targeting properties and anti-tumor effects of UCB-MSCs as gene delivery vehicles for glioma therapy.
The Relationship Between Circulating Natural Killer Cells after Reduced Intensity Conditioning Hematopoietic Stem Cell Transplantation and Relapse-Free Survival and Graft-Versus-Host Disease
In this study serial peripheral blood absolute natural killer cell counts were prospectively measured by flow cytometry of lymphocytes expressing CD56 and CD16 in 167 patients.
Biologic Properties and Enucleation of Red Blood Cells from Human Embryonic Stem Cells
This paper shows that it is feasible to differentiate and mature human embryonic stem cells into functional oxygen-carrying erythrocytes on a large scale (1010-1011 cells/6-well plate hESCs).
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