Stem Cells with Potential to Regenerate Injured Liver Tissue Identified by Penn Researchers
A novel protein marker has been found that identifies rare adult liver stem cells, whose ability to regenerate injured liver tissue has the potential for cell-replacement therapy.
Plastic Additives Leach into Medical Experiments, Research Shows
A group of scientists warned Thursday that disposable plastic laboratory equipment – things like test tubes and pipette tips – may exude compounds that can interact with solutions or cells placed in them, leading to skewed results.
Umbilical Cord Blood May Help Build Heart Valves
In what is called a concept study, researchers showed it was possible to collect blood from the umbilical cord at birth, harvest the stem cells and then make a heart valve that is ready when the baby needs it.
Yerkes Researchers Find Stem Cells from Monkey Teeth Can Stimulate Growth and Generation of Brain Cells
Rhesus monkey dental stem cells show the ability to produce different types of cells, illustrating the potential for cell therapy and regenerative medicine.
Intraspinal Implant of Mesenchymal Stem Cells May Not Heal the Demyelinated Spinal Cord
Researchers from the University of Cambridge conducted experiments using animal models to see if the direct implantation of multipotent mesenchymal stem cells into the demyelinated rat spinal cord would be therapeutic and remyelinate the sheath surrounding the nerve fibers of the spinal cord in multiple sclerosis.
Engineered Killer T-Cell Recognizes HIV-1’s Lethal Molecular Disguises
Researchers at the University of Pennsylvania School of Medicine and colleagues in the United Kingdom have engineered T cells able to recognize HIV-1 strains that have evaded the immune system.
Researchers have Identified a Novel Mechanism in the Regulation and Differentiation of Neural Stem Cells.
University of Southern California researchers found that the protein receptor Ryk has a key role in the differentiation of neural stem cells, and demonstrated a signaling mechanism that regulates neuronal differentiation as stem cells begin to grow into neurons.
Celgene Cellular Therapeutics Receives FDA Clearance for First Placenta-Derived Stem Cell Clinical Study
Celgene Cellular Therapeutics recently announced the U.S. Food and Drug Administration has accepted the company’s investigational new drug application to initiate a clinical trial using PDA001, an immunomodulatory therapy utilizing human placenta-derived stem cells obtained via CCT’s proprietary processes.
Children’s Hospital of Pittsburgh’s Study Demonstrates Unique Form of Bone Marrow Transplant Can Cure Sickle Cell Disease
A unique approach to bone marrow transplantation pioneered in part by a Children’s Hospital of Pittsburgh physician has proven to be the only safe and effective cure for sickle cell disease, according to a new study.
Celladon Announces Presentation of Clinical Data from First-in-Human Mydicar Trial for Advanced Heart Failure
Celladon Corporation announced recently results from the first nine patients treated with MYDICAR, showing the product was safe and demonstrating improvement across a number of key parameters.
ABSTRACTS, REVIEWS AND SPECIAL REPORTS
Induction of Pluripotent Stem Cells from Primary Human Fibroblasts with only Oct4 and Sox2
Here this study reports that valproic acid, a histone deacetylase inhibitor, enables reprogramming of primary human fibroblasts with only two factors, Oct4 and Sox2, without the need for the oncogenes c-Myc or Klf4.
Efficient and Rapid Generation of Induced Pluripotent Stem Cells from Human Keratinocytes
This paper shows that reprogramming of juvenile human primary keratinocytes by retroviral transduction with OCT4, SOX2, KLF4 and c-MYC is at least 100-fold more efficient and two-fold faster compared with reprogramming of human fibroblasts.
Multipotent Adult Germline Stem Cells and Embryonic Stem Cells have Similar MicroRNA Profiles
Despite the differences regarding time and extent of differentiation observed between embryonic stem cells and multipotent adult germline stem cells, expression profiles of both miRNA families showed similarities between these two cell types.
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