Salk Researchers Successfully Reprogram Keratinocytes Attached to a Single Hair
A team of researchers at the Salk Institute for Biological Studies, succeeded in boosting the reprogramming efficiency more than 100 fold, while cutting the time it takes in half over traditional methods.
Caltech Engineers Build First-Ever Multi-Input “Plug-and-Play” Synthetic RNA Device
Engineers from the California Institute of Technology have created a “plug-and-play” synthetic RNA device – a sort of eminently customizable biological computer – that is capable of taking in and responding to more than one biological or environmental signal at a time.
University of Michigan Researchers Uncover New Links between Stem Cells, Aging and Cancer
Four genes previously implicated in the control of cancer have been shown by University of Michigan scientists to play key roles in the aging process and stem-cell regulation.
Living Cell Technologies Receives Health Minister’s Approval to Start Leading Edge Live Cell Therapy Clinical Trial in New Zealand for Diabetics
Living Cell Technologies recently announced that the New Zealand Health Minister, has approved an application from the company to conduct in New Zealand a Phase I/IIa clinical trial of LCT’s lead product candidate for the treatment of insulin dependent (Type 1) diabetes.
Late Problems Seen after Hodgkin’s Disease Therapy
The chemotherapy, radiation, and stem cell therapy used to treat patients with relapsed or refractory Hodgkin’s disease are associated with significant long-term problems, including an increased risk of other cancers, according to a study in the Journal of Clinical Oncology.
Spinal Cord Stem Cell Trial could Start Soon, Report Says
A clinical trial that would test the use of embryonic stem cells to treat spinal cord injury could begin within three months thanks to a projected lifting of a Food and Drug Administration hold on the trial.
ABSTRACTS, REVIEWS AND SPECIAL REPORTS
Promotion of Reprogramming to Ground State Pluripotency by Signal Inhibition
The researchers report that brain-derived neural stem cells acquire undifferentiated morphology rapidly and at high frequency after a single round of transduction with reprogramming factors.
Lentiviral-Mediated HoxB4 Expression in Human Embryonic Stem Cells Initiates Early Hematopoiesis in a Dose-Dependent Manner but does not Promote Myeloid Differentiation
In this study, hESCs ectopically expressing high and low levels of HoxB4 were quantified throughout differentiation revealing a steady increase in transcription levels of the constructs.
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