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Scientists Find Gene Expression Profile Shared by Pluripotent Stem Cells
Using a collection of about 150 human cell samples, The Scripps Research Institute researchers created a database of global gene expression profiles that revealed all pluripotent stem cell lines showed remarkable similarity in the analysis, while other cell types were more diverse.
Worms Wiggle into Gene Therapy
Egg secretions from a worm that causes a deadly human disease may prove useful in gene therapy, according to research presented at the British Pharmaceutical Conference in Manchester.
DNA ‘Tattoos’ Link Adult, ‘Daughter’ Stem Cells Formed in Process that Guides Human, Animal Development
Using the molecular equivalent of a tattoo on DNA that adult stem cells pass to their “daughter” cells in combination with gene expression profiles, University of Utah researchers have identified two early steps in adult stem cell differentiations.
Researchers to Start Breeding Pigs for Human Organ Transplants
Scientists in London and California have begun experiments to create genetically modified organs to tackle the shortage of organs needed.
Gene Therapy Prevents Blindness in an Animal Model of Mitochondrial Dysfunction
Scientists at the Universite Pierre et Marie Curie Paris have created an animal model suitable for testing and validating gene therapies for treatment of a common mitochondrial dysfunction that causes loss of vision.
Human Embryonic Stem Cell Secretions Minimized Tissue Injury after Heart Attack
Using a novel method, researchers found that the administration of secretion from stem cells minimized heart injury by enhancing reperfusion therapy (angioplasty and cardiac bypass surgery) and reducing tissue death by another 60%.
Pluristem Successfully Concludes Final Pre-Clinical Safety Studies with PLX-PAD in Preparation for Human Trials
Pluristem Therapeutics Inc. announced recently the successful conclusion of its pre-clinical studies utilizing PLX-PAD, for the treatment of critical limb ischemia, prior to the initiation of human clinical trials.
Bostwick Therapeutics Announces Initiation of Novel Phase I/II Personalized Medicine Immunotherapy Trial for Advanced Prostate Cancer
Bostwick Therapeutics announced recently that it has received clearance from the U.S. Food and Drug Administration and the Institutional Review Board of Community Memorial Hospital, Ventura, CA., to initiate the CRITICAL (CRyotherapy and IntraTumoral Immunotherapy with immature dendritic Cells (AutoLogous)) trial.
Safety Study Indicates Gene Therapy for Blindness Improves Vision
All three people who received gene therapy at the University of Florida to treat a rare, incurable form of blindness have regained some of their vision.
Cell Medica Announces Treatment of First Patient in Late Stage Clinical Trial of Adoptive Cell Therapy
Cell Medica has recently announced the treatment of the first patient in its CMV IMPACT clinical study, a late-stage randomized confirmatory trial aimed at demonstrating the clinical effectiveness of immunoprophylactic adoptive cellular therapy for the treatment of cytomegalovirus infections in immunosuppressed patients.
Argos Therapeutics Initiates Phase II Trial in Renal Cell Carcinoma for its Arcelis(TM) Personalized Immunotherapy Platform
Argos Therapeutics recently announced the initiation of a Phase IIa trial of its AGS-003 therapy, in combination with sunitinib, for the treatment of newly diagnosed advanced renal cell carcinoma.
ABSTRACTS, REVIEWS AND SPECIAL REPORTS
Neuroprotective Effect of Transplanted Human Embryonic Stem Cell-Derived Neural Precursors in an Animal Model of Multiple Sclerosis
This paper describes that transplanted human embryonic stem cells-derived neural precursors significantly reduced the clinical signs of experimental autoimmune encephalomyelitis.
Disease-Specific Induced Pluripotent Stem Cells
In this paper, the researchers describe the generation of induced pluripotent stem cells from patients with a variety of genetic diseases with either Mendelian or complex inheritance.
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