Cell Therapy News

Cell Therapy News is an online resource dedicated to sharing the latest cell therapy, gene therapy, and regenerative medicine research.

A Programmable Peptidic Hydrogel Adjuvant for Personalized Immunotherapy in Resected Stage Tumors

[Journal Of The American Chemical Society] Investigators described a programmable hydrogel adjuvant for personalized immunotherapy after surgical resection. By filling the hydrogel in the cavity, this system addressed the limited secretion of granzyme B during immunotherapy and improve the low immunotherapy responses typically observed.

Therapeutic Effect and Study of Human Umbilical Cord Blood Mononuclear Cells in Patients with Ischaemic Bowel Disease

[Scientific Reports] Investigators discuss the clinical characteristics of ischemic bowel disease, analyse the characteristics of human umbilical cord blood mononuclear cells, and use its to treat ischaemic bowel disease.

S100A9+CD14+ Monocytes Contribute to Anti-PD-1 Immunotherapy Resistance in Advanced Hepatocellular Carcinoma by Attenuating T Cell-Mediated Antitumor Function

[Journal Of Experimental & Clinical Cancer Research] Patient blood samples were collected for single-cell RNA sequencing to evaluate the immune cell signature before receiving immune checkpoint blockade (ICB) therapy. Subsequently, in vitro assays and in vivo murine model experiments were conducted to validate the mechanism that S100A9+CD14+ monocytes play a role in ICB resistance.

Chimeric Antigen Receptors of HBV Envelope Proteins Inhibit Hepatitis B Surface Antigen Secretion

[Gut] Researchers developed multiple chimeric antigen receptors based on single-chain variable fragments, respectively, targeting HBV large and small envelope proteins. Their impacts on hepatitis B surface antigen secretion and HBV infection, and the underlying mechanisms, were extensively investigated using various cell culture models and HBV mouse models.

Ex Vivo Activation of the GCN2 Pathway Metabolically Reprograms T Cells, Leading to Enhanced Adoptive Cell Therapy

[Cell Reports Medicine] The authors reported that activating the amino acid starvation response in effector CD8+ T cells ex vivo using the general control non-depressible 2 (GCN2) agonist halofuginone enhanced oxidative metabolism and effector function.

Synthetic Receptor Scaffolds Significantly Affect the Efficiency of Cell Fate Signals

[Scientific Reports] Researchers compared the performance of three types of synthetic receptor scaffolds, i.e. myristoylated, cytosolic, and transmembrane types that signal through JAK-dependent phosphorylation of tyrosine motifs to transduce growth signaling.

Targeting HDAC6 Improves Anti-CD47 Immunotherapy

[Journal Of Experimental & Clinical Cancer Research] Investigators tested the role of HDAC6is, especially Nexturastat A, in regulating macrophage phenotype and phagocytic function using bone marrow-derived macrophages and macrophage cell lines.

Targeting Autophagy Overcomes Cancer-Intrinsic Resistance to CAR-T Immunotherapy in B-Cell Malignancies

[Cancer Communications] Scientists explored the molecular determinants of cancer cell sensitivity to CAR-T cell-mediated killing and to provide a better understanding of the underlying mechanisms and potential modulation to improve clinical efficacy.

Prediction of Tumor-Reactive T Cell Receptors from scRNA-Seq Data for Personalized T Cell Therapy

[Nature Biotechnology] Scientists combined high-throughput T cell receptors (TCR) cloning and reactivity validation to train predicTCR, a machine learning classifier that identifies individual tumor-reactive tumor infiltrating lymphocytes (TILs) in an antigen-agnostic manner based on single-TIL RNA sequencing.

Reducing and Controlling Metabolic Active Tumor Volume Prior to CAR T Cell Infusion Can Improve Survival Outcomes in Patients with Large B Cell Lymphoma

[Blood Cancer Journal] The authors assessed the influence of quantified metabolic active tumor volume (MATV) and MATV-dynamics, between pre-apheresis and pre-lymphodepleting chemotherapy MATV, on CAR T-cell outcomes and toxicities in patients with relapsed or refractory large B cell lymphoma.

Three-in-One Peptide Prodrug with Targeting, Assembly and Release Properties for Overcoming Bacterium-Induced Drug Resistance and Potentiating Anti-Cancer Immune Response

[Advanced Materials] Investigators rationally designed a novel molecule Biotin-Lys(SA-Cip-OH)-Lys(SA-CPT)-Phe-Phe-Nap containing four functional motifs, that is a biotin motif for targeting, Phe-Phe(-Nap) motif for self-assembly, ciprofloxacin derivative motif for antibacterial effect, and camptothecin.

Nanoplatform-Based In Vivo Gene Delivery Systems for Cancer Therapy

[Small] Scientists provide overview of the categories of nanoplatform-based non-viral gene vectors, the limitations on their development, and their applications in cancer therapy.

Published since 2002, Cell Therapy News is our longest running online publication. Our editorial team curates the top publications, reviews, and news on in vivo gene therapy, cell therapy, and immunotherapy research. With over 15,000 subscribers and followers across our website, email newsletter, and Twitter feed, we are proud to facilitate the communication of cutting-edge cell therapy innovations.

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