HepaLife Develops New Liver Stem Cell Lines for Bioartificial Liver Device
HepaLife Technologies, Inc., recently announced the development of two new derivative cell lines from the Company’s patented PICM-19 liver stem cells for use in HepaLife’s first-of-its-kind bioartificial liver device currently under development for the treatment of human liver failure.
Canadian Scientists Deliver on Promise of Stem Cell Therapy for Lung Disease
Two Quebecers suffering from pulmonary hypertension, a rare but debilitating lung disease, were treated in Montreal with their own gene-modified stem cells. This experimental treatment was administered at the Jewish General Hospital’s Centre for Pulmonary Vascular Disease.
UGA Research May Lead to Safer, More Effective Gene Therapy
The potential of gene therapy has long been hampered by the risks associated with using viruses as vectors to deliver healthy genes, but a new University of Georgia study helps bring scientists closer to a safe and efficient gene delivery method that doesn’t involve viruses.
Umbilical Cord Blood Cell Transplants May Help ALS Patients
A study at the University of South Florida has shown that transplants of mononuclear human umbilical cord blood cells may help patients suffering from Amyotrophic Lateral Sclerosis or Lou Gehrig’s disease. A disease in which the motor neurons in the spinal cord and brain degenerate, ALS leaves its victims with progressive muscle weakness, paralysis and, finally, respiratory failure three to five years after diagnosis.
Ronin Provides Alternate Pathway to Pristine Embryonic Stem Cells
Like the masterless samurai for whom it is named, the protein Ronin chooses an independent path, maintaining embryonic stem cells in their undifferentiated state and playing essential roles in genesis of embryos and their development.
Scientists Discover How An Injured Embryo Can Regenerate Itself
How exactly is the half embryo able to maintain its tissues and organs
in the correct proportions despite being smaller than a normal sized
embryo? Present research from scientist Prof. Naama Barkai and her colleagues developed a mathematical model to describe interactions that occur within genetic networks of an embryo.
Stem Cell Treatment in Clinical Trial at Texas Heart Institute at St. Luke’s
Scientists at the Texas Heart Institute at St. Luke’s Episcopal Hospital will use special stem cells to treat heart attack patients in the first clinical trial of its kind. Stem cells from healthy donors will be grown in cultures and injected into patients’ hearts.
Living Cell Technologies Confirms Insulin Delivery from Implants in Diabetes Clinical Trial
Living Cell Technologies Limited recently reported that patients in the DiabeCell phase I/IIa diabetes clinical trial had porcine insulin in their blood samples providing additional scientific confirmation that implants of DiabeCell actively produce insulin and directly contribute to clinical benefit.
Genta Updates Progress of its Phase 3 Trial of Genasense in Patients with Advanced Melanoma
Genta Incorporated announced the presentation of a progress update from an ongoing Phase 3 trial of Genasense (oblimersen sodium) Injection, the Company’s lead oncology product, in patients with advanced melanoma. The study is designed to confirm certain safety and efficacy results from Genta’s prior randomized trial of Genasense combined with dacarbazine in patients identified by a biomarker who have not previously received chemotherapy.
ABSTRACTS, REVIEWS AND SPECIAL REPORTS
Regenerative Effect of Neural-Induced Human Mesenchymal Stromal Cells in Rat Models of Parkinson’s Disease
Human bone marrow multipotent mesenchymal stromal cells, because of their capacity of multipotency, may provide an unlimited cell source for cell replacement therapy. The purpose of this study was to assess the developmental potential of hMSC to replace the midbrain dopamine neurons selectively lost in Parkinson’s disease.
Bone Marrow Mesenchymal Stem Cell Transplantation Improves Ovarian Function and Structure in Rats with Chemotherapy-Induced Ovarian Damage
Many investigations have reported that mesenchymal stem cell transplantation can ameliorate the structure and function of injured tissues. The purpose of this study was to explore the therapeutic potency of MSC transplantation for chemotherapy-induced ovarian damage.
A Novel Method for Generating Xeno-Free Human Feeder Cells for Human Embryonic Stem Cell Culture
Long-term cultures of human embryonic stem cells require a feeder layer for maintaining cells in an undifferentiated state and increasing karyotype stability. We demonstrate that animal-free HFFs do not enter senescence within 55 passages when cultured in animal-free conditions. This methodology offers alternative and completely animal-free conditions for hES cell culture, thus maintaining hES cell morphology, pluripotency, karyotype stability, and expression of pluripotency markers.
iPS Cells: A More Critical Review
Over the past 20 months, reports claiming the generation of induced pluripotent stem cells with characteristics identical to those of embryonic stem cells from nonembryonic tissue have captured great attention in both the scientific community and the general public. This review calls into question the validity of many claims made in these reports-claims that have led to the rapid and premature acceptance of using iPS cells as a viable alternative to using normal stem cells for regenerative therapy.
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