VIDEO: Adult Stem Cells Aid Fracture Healing; UNC Study Lays Groundwork for Potential Treatments
In an approach that could become a new treatment for the 10 to 20 percent of people whose broken bones fail to heal, researchers at the University of North Carolina at Chapel Hill have shown that transplantation of adult stem cells can improve healing of fractures. The study is the first to visualize the action of transplanted adult stem cells as they mend fractures in mice.
Penn Researchers Find Key Developmental Pathway Activates Lung Stem Cells
Researchers from the University of Pennsylvania School of Medicine found that the activation of a molecular pathway important in stem cell and developmental biology leads to an increase in lung stem cells.
Singapore Scientists Discover a Wealth of Genomic Hotspots in Embryonic Stem Cells Which Will Pave the Way for Important Advancements in Cell Reprogramming, Renewal and Pluripotency
A paper published in Cell on June 13, 2008 describes how Singapore scientists from the Genome Institute of Singapore and the National University of Singapore have successfully unveiled an atlas that shows the location of “genomic hotspots” of essential protein “switches” (transcription factors), which are critical for maintaining the state of embryonic stem cells.
iPS Stem Cell Method Improved
Shinya Yamanaka of Kyoto University and the Gladstone Institute of Cardiovascular Disease – who pioneered the reprogramming method in mice in 2006, then shared the breakthrough in human cells with James Thomson at the University of Wisconsin-Madison – said that he had achieved better results by combining his method with Thomson’s.
Researchers Create Molecule that Nudges Nerve Stem Cells to Mature
Inspired by a chance discovery during another experiment, researchers at UT Southwestern Medical Center have created a small molecule that stimulates nerve stem cells to begin maturing into nerve cells in culture.
Scientists Use ‘Biological Alchemy’ to Convert One Cell Type Into Another
Prof Melton told the annual meeting of the International Society for Stem Cell Research in Philadelphia how he took specialist “pancreatic exocrine cells” that secrete digestive enzymes, which make up to 95 per cent of the pancreas, and converted them directly into another cell type, called beta cells, which make the hormone insulin to control blood sugar levels.
Ability To Track Stem Cells in Tumors Could Advance Cancer Treatments
Using noninvasive molecular imaging technology, a method has been developed to track the location and activity of mesenchymal stem cells in the tumors of living organisms. This ability could lead to major advances in the use of stem cell therapies to treat cancer.
Gene Therapy Improves Survival and Quality of Life of Dogs with Cancer
A new gene therapy has helped pet dogs with cancer live longer and could potentially improve the quality of life and survival of people with cancer, said the therapy’s developers. The single treatment works by increasing muscle strength and correcting common complications of cancer such as weakness, weight loss and anemia, said principal investigator Ruxandra Draghia-Akli, MD, PhD, researcher, VGX Pharmaceuticals Inc., The Woodlands, Tex.
Patient’s Own Infection-Fighting T Cells Put Late-Stage Melanoma into Long-Term Remission – Without Chemotherapy or Radiation
Researchers describe the first successful use of a human patient’s cloned infection-fighting T cells as the sole therapy to put an advanced solid-tumor cancer into long-term remission. A team led by Cassian Yee, M.D., an associate member of the Clinical Research Division at Fred Hutchinson Cancer Research Center, reports these findings in the June 19 issue of the New England Journal of Medicine.
Intensive Induction Therapy Followed by Stem-Cell Support and Consolidation Therapy Produces High Responses in Elderly With Multiple Myeloma
Nearly 90% of elderly patients with newly diagnosed multiple myeloma responded to an intensive sequential treatment regimen of induction therapy with bortezomib, pegylated-liposomal doxorubicin, and dexamethasone followed by autologous stem-cell transplantation, and then consolidation with lenalidomide and prednisone.
ABSTRACTS, REVIEWS AND SPECIAL REPORTS
Chronic Graft-Versus-Host Disease Following Umbilical Cord Blood Transplantation: Retrospective Survey Involving 1,072 Patients in Japan
The researchers investigated chronic Graft-Versus-Host Disease after cord blood transplantation’s clinical features in 1,072 Japanese patients with hematologic malignancies transplanted through the Japan Cord Blood Bank Network. The primary end point was to investigate the incidence of any chronic Graft-Versus-Host Disease.
BIO Chief Talks About Industry’s Concerns
The biotechnology industry considers funding for the Food and Drug Administration and the National Institutes of Health, as well as rules for making generic drugs, as its top political issues this year, said James Greenwood, who heads the national Biotechnology Industry Organization.
Stem Cell Field Grows Despite Controversy: Experts
Political controversy may have slowed the pace of stem cell science, but the field is still promising enough to attract many talented researchers, stem cell experts said on Saturday.
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