VIDEO: From MEFs to Matrigel I: Passaging hESCs in the Presence of MEFs
This video demonstrates how to grow human embryonic stem cells on mouse embryonic fibroblast feeder cells.
Stem Cell Discovery Sheds Light on Placenta Development
University of Florida Researchers studying embryonic stem cells have explored the first fork in the developmental road, getting a new look at what happens when fertilized eggs differentiate to build either an embryo or a placenta.
Geron Presents Data at ISSCR Showing That Its Embryonic Stem Cell Therapeutic for Heart Failure Evades Direct Attack by the Human Immune System
Geron Corporation recently announced the presentation of research studies indicating that GRNCM1, the company’s human embryonic stem cell–based therapeutic for the treatment of heart failure, evades direct attack by the human immune system in vitro.
Shear Stress Improves Stem Cell Attachment to Vascular Surfaces
A new study about how shear stress improves adult stem cell attachment to vascular surfaces moves researchers closer to the development of a unique tissue-engineered stem cell vascular bypass graft.
ImmuneRegen(R) BioSciences Confirms Adult Stem Cell Activity of Homspera(R) in Human Bone Marrow
ImmuneRegen(R) BioSciences, Inc., announces additional study results that confirm the effects of its compound Homspera(R) in stimulating the development of human adult stem cells. The results, also found in earlier studies, document Homspera’s ability to enhance formation of early-stage blood cells from adult hematopoietic (blood-forming) stem cells.
Researchers Create New PET-Scan Probe to Monitor Immune System
Researchers at UCLA’s Jonsson Comprehensive Cancer Center have modified a common chemotherapy drug to create a new probe for positron emission tomography, an advance that will allow them to model and measure the immune system in action and monitor its response to new therapies.
Engineer Develops Detergent to Promote Peripheral Nerve Healing; 100 Patients Treated Successfully in First Year of Use
A detergent solution developed at The University of Texas at Austin that treats donor nerve grafts to circumvent an immune rejection response has been used to create acellular nerve grafts now used successfully in hospitals around the country. Research also shows early promise of the detergent solution having possible applications in spinal cord repair.
Autologous Haematopoietic Stem Cell Transplantation After Immunosuppressive Therapy Effective and Safe in Multiple Sclerosis
In patients with multiple sclerosis, immunosuppressive therapy followed by autologous haematopoietic stem cell transplantation elicited high response rates and improved quality of life for up to 6 years.
AMT prepares for submission of Marketing Authorization Dossier for AMT-011 (Glybera(R))
Amsterdam Molecular Therapeutics, a leader in the field of human gene therapy, announced recently that it has concluded enrollment and treated the last patient in the pivotal trial for it’s lead product AMT-011 (Glybera(R)) for Hyperlipoproteinemia, a seriously debilitating and potentially lethal disease. After recent preparatory meetings with the rapporteur countries Germany and the United Kingdom of the European Medicines Agency, AMT expects to file the Marketing Authorization Dossier with EMEA not later than the fourth quarter of 2008.
ABSTRACTS, REVIEWS AND SPECIAL REPORTS
Efficient Differentiation of Functional Hepatocytes from Human Embryonic Stem Cells
The researchers report here a robust and highly efficient process for the generation of high-purity (70%) hepatocyte cultures from hESCs that parallels sequential hepatic development in vivo. Highly enriched populations of definitive endoderm were generated from hESCs and then induced to differentiate along the hepatic lineage by the sequential addition of inducing factors implicated in physiological hepatogenesis.
Inhalable siRNA: Potential as a Therapeutic Agent in the Lungs
Targeted, local delivery of RNAi to the lungs via inhalation offers a unique opportunity to treat a range of previously untreatable or poorly controlled respiratory conditions. In this timely review the researchers look at the potential applications of RNAi in the lungs for the treatment of a range of diseases including inflammatory and immune conditions, cystic fibrosis, infectious disease and cancer.
Nuclear Pore Composition Regulates Neural Stem/Progenitor Cell Differentiation in the Mouse Embryo
Here the researchers report that a null allele of mouse nucleoporin Nup133, a structural subunit of the NPC, disrupts neural differentiation. We find that expression of Nup133 is cell type and developmental stage restricted, with prominent expression in dividing progenitors.
Scientific Information Largely Ignored When Forming Opinions About Stem Cell Research
When forming attitudes about embryonic stem cell research, people are influenced by a number of things. But understanding science plays a negligible role for many people.
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