Scientist Uses Chemicals To Create iPS Cells
Sheng Ding, associate professor at the Scripps Research Institute in California revealed Sunday at a science conference in Kyoto that he had succeeded in creating induced pluripotent stem cells of both mice and humans after replacing one or two of the four genes used in creating iPS cells with synthetic chemicals.
Stem Cells Might Contribute to Vascular Disease
A team of scientists – led by Dr. K. Craig Kent, Greenberg-Starr Professor and professor of surgery at Weill Cornell Medical College and chief of the Division of Vascular Surgery at NewYork-Presbyterian – are currently studying how stem cells implant themselves in the wall of arteries and grow out of control.
UC Davis Children’s Hospital Researchers Identify Candidate Adult Bladder Stem Cells
Researchers at UC Davis Children’s Hospital have identified the potential stem cells that become the bladder, adding to the body of research that already has identified stem cells that can regenerate many of the body’s other organs.
Decoding Muscle Stem Cell Development
Muscle stem cells can’t grow into mature muscle cells if there aren’t enough nutrients, according to a study that offers new insight into how developing muscle cells sense and respond to nutrient levels.
How Embryonic Stem Cells Develop Into Tissue-Specific Cells Demonstrated by Hebrew University and Other Researchers
Researchers at the Hebrew University of Jerusalem and elsewhere have succeeded in graphically revealing the mechanism of how embryonic stem cells’s develop into any kind of tissue-specific cells, resolving a long-standing question as to whether the stem cells achieve their development through selective activation or selective repression of genes.
UC Davis Stem Cell Researchers Demonstrate Safety of Gene Therapy Using Adult Stem Cells
A new study by UC Davis researchers provides evidence that methods using human bone marrow-derived stem cells to deliver gene therapy to cure diseases of the blood, bone marrow and certain types of cancer do not cause the development of tumors or leukemia.
MIT Researchers Find Novel Way to Repair Airway Injuries
The new technique heals airway injuries by placing new tracheal cells around the injury site. Two types of tracheal cells, embedded within a three-dimensional gelatin scaffold, take over the functions of the damaged tissue.
FDA Places Geron’s GRNOPC1 IND on Clinical Hold
Geron Corporation announced recently that the company received verbal notice recently from the FDA that the company’s Investigational New Drug submission for GRNOPC1, a cell therapy for spinal cord injury, has been placed on clinical hold.
Argos Therapeutics Initiates Phase 2 Proof-of-Concept Trial for its Arcelis(TM) Personalized Immunotherapy Platform in HIV
Argos Therapeutics recently announced the initiation of a Phase 2a proof-of-concept clinical trial to test the efficacy of its AGS-004 therapy in improving immune control of viral replication in HIV-infected adults. AGS-004 is a product of the Company’s Arcelis(TM) technology, a personalized, RNA-loaded dendritic cell-based immunotherapy that is perfectly matched to each patient’s unique HIV viral burden.
Mesoblast’s Cells Show Long-Lasting and Sustained Effect in Knee Osteoarthritis
Mesoblast Limited recently announced succesful long-term results in its osteoarthritis preclinical trials. A single injection of its propiretary allogeneic, or “off-the-shelf”, adult stem cells into arthritic knees provided sustained protection against cartilage destruction and degeneration for up to nine months.
Mesenchymal Stem Cells Can Suppress Life-Threatening Immune Reaction
Treatment with mesenchymal stem cells has shown to be an effective therapy for patients with severe graft-versus-host disease, a life-threatening complication after allogeneic transplantation with haemopoietic stem cells.
NewYork-Presbyterian/Weill Cornell Gene Therapy Clinical Trial Yields Promising Results for Batten Disease, Fatal Neurological Condition
Promising results from a team of NewYork-Presbyterian Hospital/Weill Cornell Medical Center physician-scientists show that gene therapy is both safe and effective at slowing the progression of Batten disease, or Late Infantile Neuronal Ceroid Lipofuscinosis, a rare, genetic, degenerative neurological disorder that usually becomes fatal in children by the age of 8 to 12.
Microfabrication of Chip-Sized Scaffolds for Three-Dimensional Cell Cultivation
Dr. Stefan Geiselbrecht of the Institute of Biological Interfaces, presents two processes for the microfabrication of porous polymer chips for three-dimensional cell cultivation.
ABSTRACTS, REVIEWS AND SPECIAL REPORTS
Efficient Production of Mice from Embryonic Stem Cells Injected Into 4- or 8- Cell Embryos by Piezo Micromanipulation
In this study, researchers report a simple method for producing F0 ES cell- germline competent mice by Piezo injection of ES cells into 4- or 8-cell embryos, making this procedure more efficient and economical in laboratories.
Disturbance of Pro-oxidative/Antioxidative Balance in Allogeneic Peripheral Blood Stem Cell Transplantation
The aims of the study were to determine the effect of allogeneic HSCT on plasma concentrations of antioxidants and oxidative stress biomarkers, and to investigate their relationships with graft-versus-host disease, conditioning regimens, and transplant-related mortality in patients with hematological malignancies.
Functional Recovery in T13–L1 Hemisected Rats Resulting From Peripheral Nerve Rerouting: Role of Central Neuroplasticity
Neurotized SCI animals demonstrated multiparameters of neural reorganization in the distal lumbar cord, including enhanced proliferation of endogenous neural stem cells, increased immunoreactivity of serotonin and synaptophysin, and neurite growth/sprouting, suggesting that anastomosing functional nerves with the nerve stump emerging distal to the hemisection stimulates neuroplasticity in the dysfunctional spinal cord.
Development of a Novel Assay to Evaluate the Functional Potential of Umbilical Cord Blood Progenitors
Although the colony-forming cell assay provides the most relevant information regarding the functional potential of progenitors in a unit of umbilical cord blood, technical challenges associated with this assay have made it difficult to standardize the assay among testing laboratories. The purpose of this study was to assess the reproducibility of a newly developed functional assay (HALO SPC-QC [HALO], HemoGenix, Inc.).
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