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Drug Firms Cool to Stem Cell Findings
Despite excitement among some scientists – and at the White House – about an embryo-free technique for creating human stem cells, reaction from companies that might turn the research into treatments was muted.
Dolly Scientist Abandons Cloning
The scientist who led the team that controversially created Dolly the sheep is abandoning the cloning of human embryos in stem cell research.
Covalon Achieves Important Milestone in Its Cell-Based Gene Therapy for Treating Congestive Heart Failure and Tissue Regeneration
Covalon Technologies Ltd. is pleased to announce that it has successfully achieved an important milestone with its EPAS1 technology that is expected to allow Covalon to engineer mesenchymal stem cells for increased expression of EPAS1, a hypoxia inducible factor.
St. Jude Finds Molecule that Could Improve Cancer Vaccines and Therapy for Other Diseases
Investigators at St. Jude Children’s Research Hospital have discovered a new signaling molecule that prevents immune responses from running amok and damaging the body.
Immune System Can Drive Cancers Into Dormant State
A multinational team of researchers has shown for the first time that the immune system can stop the growth of a cancerous tumor without actually killing it.
Stem Cell Injection Protects Against Nerve Cell Death After Stroke, Study Suggest
Scientists have tested the capabilities of cellular therapy for ischemic stroke treatment on rats. It has turned out that intravenous transplantation of mesenchymal stem cells restores cerebrum blood supply and protects its nerve cells from death.
Stem Cell Transplant Can Grow New Immune System in Certain Mice, Stanford Researchers Find
The researchers found a way to transplant new blood-forming stem cells into the bone marrow of mice, effectively replacing their immune systems.
Gene Therapy Safety Trial for Childhood Blindness Under Way
A gene-transfer technique is being tested for safety in people in a phase 1 clinical research study conducted by the University of Pennsylvania and the University of Florida with support from the National Eye Institute of the National Institutes of Health.
Athersys IND For MultiStem Authorized For Phase I Clinical Trial In Bone Marrow Transplant Support
Athersys, Inc. announced that it has been notified by the U.S. Food and Drug Administration that its Investigational New Drug, MultiStem(r), can proceed to a Phase I clinical trial evaluating the safety of MultiStem administration in support of bone marrow transplantation for the treatment of certain cancers of the blood and immune system.
Biobanks Now Feasible in Developing Countries
Technological advances and other innovations have made it feasible for developing countries to establish biobanks – repositories of human biological samples linked with data from individuals, write S. K. Sgaier and colleagues in Science.
ABSTRACTS, REVIEWS AND SPECIAL REPORTS
A Roadmap to Safe, Efficient, and Stable Lentivirus-Mediated Gene Therapy with Hematopoietic Cell Transplantation
This review summarizes the state of the field today in terms of vector development and clinical experimentation. In particular, concerns with the safety of retroviral vectors intended for clinical gene transfer, applicability of preclinical data in directing clinical trial design, and recent research aimed at resolving some of these issues are addressed. Finally, this review underlines the specific advantages offered by lentiviral gene-transfer vectors for gene therapy in stem cells.
Clinical Development Research Associate
Poway, California (VetStem)
Islet Cell Associate Research Director
Irvine, CA (University of California, Irvine)