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October 22, 2007
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Scientists Identify Stem Cells in Tendons
U.S. scientists have discovered stem cells in adult tendons can regenerate tissue – a finding that promises new treatments for tendon injury and disease.
How To Isolate Stem Cells In Womb Tissue
Scientists in Australia have found a way of identifying probable stem cells in the lining of women’s wombs. The finding opens up the possibility of using the stem cells for tissue engineering applications such as building up natural tissue to repair prolapsed pelvic floors.
Embryonic Stem Cell Strategy Advanced with UCSF Finding
UCSF scientists are reporting what they say is a significant improvement in the technique for genetically reprogramming mouse cells to their embryonic state, a process that transforms the cells, in essence, into embryonic stem cells.
A Step Toward Tissue-engineered Heart Structures for Children
Researchers at Children’s Hospital Boston have now described making pulmonary valves through tissue engineering.
Putting Stem Cell Research on the Fast Track
Engineers at Rensselaer Polytechnic Institute have developed tools to help solve two of the main problems slowing the progress of stem cell research – how to quickly test stem cell response to different drugs or genes, and how to create a large supply of healthy, viable stem cells to study from only a few available cells.
Delivering Gene Therapy
A team of Italian Researchers is opening a route for delivering nucleic acid-based therapies into cells without using potentially problematic viruses as carriers.
BrainStorm Cell Therapeutics Takes Initial Steps Toward FDA Submission
BrainStorm Cell Therapeutics Inc. has announced that the Company has completed a preliminary meeting with representatives of the FDA Office of Cellular, Tissues and Gene Therapies, to discuss BrainStorm’s preclinical research program in Parkinson’s Disease.
Breakthrough Research Identifies How Cells from Pigs May Cure Diabetes
Within three years, insulin-producing islet cells from pigs may be used in clinical trials on a path to finally cure insulin dependant diabetes.
Stem Cell Therapy Disappoints Against Rare Kidney Ailment
In a disheartening result that confounds existing research, a team in France says a new stem cell therapy for a rare kidney disease is no better than the usual chemotherapy-only approach.
Allogeneic T-Cell Therapy Effective Against Post-Transplant EBV-Related Tumors
Partially HLA-matched allogeneic cytotoxic T-cell therapy shows promise in treatment of Epstein-Barr virus-positive post-transplantation lymphoproliferative disease, according to British and Australian researchers.
Opexa Therapeutics Gives Update on Phase IIb Trial of Tovaxin(R) for Treatment of Multiple Sclerosis
Opexa Therapeutics, Inc. has provided an update on its 150-patient Phase IIb safety and efficacy study of Tovaxin(R) in multiple sclerosis. The trial design is a U.S. multicenter, randomized, double-blind, placebo-controlled study of subcutaneous Tovaxin in subjects with Clinically Isolated Syndrome or Relapsing/Remitting Multiple Sclerosis.
Stem Cell Use is Blood Bank’s Gain
Of the thousands of stem cell transplants performed annually worldwide on cancer patients, just 1 to 2 percent use samples taken from umbilical cord blood and placentas donated by the mothers of newborns. But that figure is expected to rise dramatically in the next decade – to as high as 50 percent, if stem cell researchers and advocates are correct in their projections.
Help for Hounds
While many promising stem cell therapies are still awaiting approval for use in humans, vets are already using the technology to treat arthritis and tendon ailments in dogs and horses.
Most Science Studies Appear to Be Tainted By Sloppy Analysis
We all make mistakes and, if you believe medical scholar John Ioannidis, scientists make more than their fair share. By his calculations, most published research findings are wrong.
ABSTRACTS, REVIEWS AND SPECIAL REPORTS
A Tissue Engineering Approach to Progenitor Cell Delivery Results in Significant Cell Engraftment and Improved Myocardial Remodeling
This study found that pluripotent hMSCs can be efficiently delivered to a site of myocardial injury using an epicardial cardiac patch, and such delivery results in improved myocardial remodeling after infarction.
Co-expression of Two Perivascular Cell Markers Isolates Mesenchymal Stem-like Cells from Human Endometrium
This study shows that human endometrium contains a small population of MSC-like cells that may be responsible for its cyclical growth, and may provide a readily available source of MSC for tissue engineering applications.