Gene Plays Key Role in Embryonic, Adult Stem Cells
One gene directs both embryonic and adult stem cells to perform the self-renewal function that is crucial in their potential broad use in medical treatments.
Adult Stem Cells May Have Smarts to Guard Against Cancer
Some bewildering behavior seen in the stem cells of muscles has led researchers at the Stanford University School of Medicine to an unexpected discovery that could explain why cancer isn’t more common.
Gelatin-Based Nanoparticle Effective in Gene Therapy for Breast Cancer
Northeastern University professor Mansoor Amiji and graduate student Sushma Kommareddy have published a new paper that examines the potential of engineered gelatin-based nanoparticles to deliver therapeutic genes to human breast cancer tumors implanted in mice.
Liver Regeneration May Be Simpler Than Previously Thought
The way the liver renews itself may be simpler than what scientists had been assuming. A new study provides new information on the inner workings of cells from regenerating livers that could significantly affect the way physicians make livers regrow in patients with liver diseases such as cirrhosis, hepatitis, or cancer.
Introgen’s Intravenous Nanoparticle Gene Therapy Shows Activity in Stage IV Lung Cancer Patients
A cancer-suppressing gene has been successfully delivered into the tumors of stage IV lung cancer patients via Introgen Therapeutics, Inc.’s intravenously administered lipid nanoparticle product candidate INGN 401.
Living Cell’s Diabetes Drug to Trial
Biotechnology company Living Cell Technologies has been granted New Zealand regulatory approval to proceed to Phase I and IIa trials of its diabetes drug, DiabeCell.
Cell Genesys Reports GVAX Immunotherapy for Prostate Cancer Induces a Broad, Patient-Specific Antibody Response
Evaluation of antibody responses in patients with advanced prostate cancer from these studies shows that the GVAX cell-based immunotherapy induces antibody responses to a broad array of prostate cancer- associated antigens, including some not previously known to be associated with prostate cancer.
Sports Medicine Miracles?
Designer “spare parts” for ruptured tendons and torn ligaments. Stem cell injections to heal and build muscle. Medical therapeutics that would allow star athletes to extend their careers by years, if not decades.
ABSTRACTS, REVIEWS AND SPECIAL REPORTS
Direct Differentiation of Human Embryonic Stem Cells to Hepatocyte-like Cells Exhibiting Functional Activities
This study discusses a differentiation system that shows that hESCs can be differentiated to hepatocyte-like cells capable of executing a range of hepatocyte functions.