Penn Study Points to New Direction for Pancreas Cell Regeneration
Past studies in tissue culture have suggested that one type of pancreas cell could be coaxed to transform into insulin-producing islet cells. Now, researchers at the University of Pennsylvania School of Medicine have demonstrated that these pancreatic acinar cells do not become insulin-producing cells in an animal model. However, they did show that injured pancreatic cells readily regenerate back into healthy acinar cells, which has implications for treating cancer and inflammation of the pancreas.
National Center for Regenerative Medicine Study Shows Isolation of Cochlear Stem Cells May Lead to a Treatment for Hearing Loss
Researchers have isolated “cochlear stem cells” located in the inner ear and already primed for development into ear-related tissue due to their proximity to the ear and expression of certain genes necessary for the development of hearing.
Womb Transplant Pregnancy Success
Four sheep have become pregnant after having their wombs removed and then reconnected.
Cell Genesys Provides Final Median Survival Data From Second Phase 2 Trial of GVAX Immunotherapy for Prostate Cancer
Additional follow-up of the 22 patients who received the dose that is comparable to that being employed in the company’s ongoing Phase 3 program indicates that the median survival is 35.0 months.
LCT Reports Major Step Forward for Islet Transplantation
LCT announced it has published evidence outlining the survival and identification of live porcine islet cells and insulin production in a human patient 10 years after receiving a pig islet cell transplant.
New Therapy Stems Degeneration in Parkinson’s Patient
In a major breakthrough in the area of stem cell therapy, Manipal Hospital has successfully treated a patient of Parkinson’s disease with stem cells.
University of Minnesota Offers Another Option For Unused Embryos
After a clinic completes an agreement with the university, it will be one of two IVF clinics in the state giving patients the chance to donate embryos to university stem-cell researchers.
Dolly Creator Wants to Work With Koreans
Professor Ian Wilmut of the University of Edinburgh, who is famous for cloning the sheep “Dolly” in 1996, said he still doesn’t want to work with South Korea’s discredited scientist Hwang Woo-suk, but hopes to team up with other Korean scientists including Hwang’s colleagues.
ABSTRACTS, REVIEWS AND SPECIAL REPORTS
Adipose Tissue-Derived Stromal Cells—Basic and Clinical Implications for Novel Cell-Based Therapies
It is the aim of this review to describe the preparation and isolation procedures for Adipose Tissue-Derived Stromal Cells (ADSC), to summarize the molecular characterization of ADSC, to describe the differentiation capacity of ADSC, and to discuss the mechanisms and future role of ADSC in cell therapy and tissue engineering.
Persistent Dopamine Functions of Neurons Derived from Embryonic Stem Cells in a Rodent Model of Parkinson Disease
Here, the researchers show that, after transplantation into an animal model, neurons derived from mouse ES cells survived for over 32 weeks, maintained midbrain markers, and had sustained behavioral effects.
Transplantation of Mesenchymal Stem Cells Is an Optimal Approach for Plastic Surgery
Mesenchymal stem cells (MSCs) are able to differentiate into a variety of cell types, offering promising approaches for stem cell-mediated tissue regeneration. Here, the researchers explored the potential of utilizing MSCs to reconstruct orofacial tissue, thereby altering the orofacial appearance.