B.C. Cancer Researchers’ Mice Stem Cell Find Could Help Leukemia Treatment
A B.C. Cancer Agency team led by Dr. Connie Eaves discovered the blood stem cells in fetal and adult mice are markedly different and switch dramatically to the adult type from the fetal type between three and four weeks after birth.
Novel Peptide Could Boost Availability and Success of Islet Cell Transplant for Type-1 Diabetes
A peptide developed by scientists at Weill Cornell Medical College may expand the availability and durability of islet cell transplant for patients with type-1 diabetes, which is characterized by a lack of these insulin-producing cells.
A New Look into Cancer’s Roots
Advances in molecular biology and the current boom in stem cell research have spurred renewed interest in the idea that stem cells are at the root of cancer – and renewed skepticism.
Protein Found to Shield Pancreatic Cancer Cells from Self-Destruction
An overexpressed protein protects human pancreatic cancer cells from being forced to devour themselves, removing one of the body’s natural defenses against out-of-control cell growth.
DNA Nanoparticles Hold Promise In Gene Therapy For Parkinson’s Disease
Researchers are testing the feasibility of using a novel technology to condense DNA plasmids into nanoparticles and deliver them to the brain as a means to halt or prevent the neurodegenerative process.
Advanced Cell Technology hESC lines to be used in CIRM-Funded Study To Test Development of New Therapies For Heart Disease
Preclinical studies using hESCs derived from Advanced Cell Technology, Inc.’s proprietary ACTcellerate technology (a means of accelerating the discovery of products from hESC) will be used as part of a study to determine if hESCs are safe and effective in animal models for heart attacks and heart failure.
Mice See New Hue With Added Gene
Providing a kaleidoscopic upgrade to creatures that are largely colorblind, scientists have endowed mice with a human gene that allows the rodents to see the world in full Technicolor splendor.
ViaCell Announces Commencement of ViaCyte Pivotal Trial
ViaCell, Inc. has announced it has initiated a clinical trial to evaluate the safety and efficacy of ViaCyteSM, an investigational product being studied for the cryopreservation and thawing of human oocytes for use during assisted reproductive technology.
Brain Tumor Vaccine Developed by Stanford Researcher to Be Tested at 20 Sites Nationally
Originally developed by Albert Wong, MD, professor of neurosurgery and member of the Stanford Comprehensive Cancer Center, results so far have been promising enough to spur a 20-center trial sponsored by Celldex, the New Jersey-based company developing the therapy.
Potential for Adult Stem Cells to Repair Hearts Damaged by Severe Coronary Artery Disease Investigated in Ongoing Study
The Autologous Cellular Therapy CD34-Chronic Myocardial Ischemia (ACT34-CMI) trial is the first Phase II adult stem cell therapy study in the U.S. designed to investigate the efficacy, tolerability and safety of blood-derived selected CD34+ stem cells to improve symptoms and clinical outcomes in patients with chronic myocardial ischemia (CMI), a severe form of coronary artery disease.
Sports Medicine Turns to Stem Cell ‘Repair Kits’
Doctors and researchers say that in a few years the use of primitive stem cells from infants’ umbilical cord blood could grow new knee ligaments or elbow tendons, creating a therapy that becomes the vanguard of sports injury repair.
Umbilical Cord Cells: Godsend or Gimmick?
As the trend of banking cord blood continues to grow, critics say those who bank umbilical cord cells at private banks will most likely never use it.
Fresh Questions on Stem Cell Findings
Fresh questions surround some of the highest-profile research on adult stem cells. For the second time, New Scientist has discovered apparently duplicated data being used to describe results from different experiments in work published by a group of scientists at the University of Minnesota, Minneapolis.
New Trend in Organ Donation Raises Questions
The number of kidneys, livers and other body parts surgeons are harvesting through a controversial approach to organ donation has started to rise rapidly, a trend that is saving the lives of more waiting patients but, some say, risks sacrificing the interests of the donors.
ABSTRACTS, REVIEWS AND SPECIAL REPORTS
Plasmid-based Gene Therapy of Diabetes Mellitus
This review shows that gene transfer of immunoregulatory molecules can prevent Type I diabetes mellitus and other autoimmune diseases.
Wnt/Beta-catenin/CBP Signaling Maintains Long-term Murine Embryonic Stem Cell Pluripotency
Using a high-throughput, cell-based assay, the researchers identified the small molecule IQ-1 that allows for the Wnt/-catenin-driven long-term expansion of mouse ESCs and prevents spontaneous differentiation.