Aldagen IND for Stem Cell Clinical Trial to Treat Critical Limb Ischemia Is Cleared By FDA
Aldagen, Inc. announced that the U.S. Food and Drug Administration (FDA) has cleared an Investigational New Drug (IND) application to conduct a clinical trial using Aldagen’s ALDESORT product to isolate a unique stem cell population for therapy for critical limb ischemia patients.
First Clinical Trial of Stem Cell Therapy to Treat Peripheral Artery Disease Underway in Thailand
TheraVitae Ltd. announced that the first clinical trial using its autologous adult stem cells from peripheral blood to treat patients suffering from severe Peripheral Artery Disease (PAD) of the lower limbs has commenced at Siriraj Hospital in Bangkok, Thailand.
Techniques Push Stem Cells to Repair Damaged Nerves
Two new studies suggest that use of cells derived from bone marrow, as well as a seaweed-derived product called hydrogel, may prompt stem cells to repair nerve damage caused by stroke or spinal cord injury.
Nano-Patterns Guide Stem Cell Development
Stem cells can be prompted to develop into bone, instead of muscle or cartilage tissue, if they are grown on a substrate etched with nanoscopic patterns – and no added chemicals – researchers have found.
Stem Cells – An Alternative to Skin Grafting?
A Singapore company has used stem cells to help victims of serious burns and other wounds grow fresh skin.
MicroIslet Announces Encouraging Data From Islet Transplantation Studies in Primates
The data shows that minimally-invasive transplantation of encapsulated porcine islets into diabetic primates resulted in significant and prolonged (greater than 30 days) improvement of blood sugar, with reduced insulin use, in the primate subjects.
Scientists in U.S. to Attempt Human Cloning South Koreans Faked
American scientists plan to create stem cells that have a genetic makeup identical to that of living human adults, a feat that Korean scientists falsely claimed they accomplished last year.
Cell Division Rewind Button Found
Scientists have found a way to reverse the process of cell division, previously thought to be unstoppable.
Gene Therapy Can Battle Blood Pressure Problems
Using a corrective gene, scientists at the University of Florida have been successful in blocking a protein in the kidneys that triggers high blood pressure and kidney damage.
The Notch Effect Steers Stem Cells into Cells of the Nervous System
Stem cell scientists at the University of Edinburgh have discovered that Notch, a protein first discovered more than 80 years ago in the fruit fly, directs unspecialized embryonic stem cells to become cells of the nervous system.
Print Me a Heart and a Set of Arteries
Sitting in a culture dish, a layer of chicken heart cells beats in synchrony. But this muscle layer was not sliced from an intact heart, nor even grown laboriously in the lab. Instead, it was “printed”, using a technology that could be the future of tissue engineering.
ABSTRACTS, REVIEWS & SPECIAL REPORTS
Notch Promotes Neural Lineage Entry by Pluripotent Embryonic Stem Cells
In this study we report that Notch receptors and ligands are expressed in ES cells where they play a previously unsuspected role in the promotion of primary neural fate.
The Reversibility of Mitotic Exit in Vertebrate Cells
These findings demonstrate that proteasome-dependent degradation of cyclin B provides directionality for the M phase to G1 transition.
Monocytes/Macrophages Cooperate with Progenitor Cells during Neovascularization and Tissue Repair
Long-term implantation of Matrigel plugs qualifies as a novel experimental model of tissue regeneration, in which neovascularization intimately couples with fibrosis and organogenesis and in which cells of MC/Mph phenotype play a key structural role.