Cell Therapy News

Cell Therapy News is an online resource dedicated to sharing the latest cell therapy, gene therapy, and regenerative medicine research.

Revolutionizing Pancreatic Islet Organoid Transplants: Improving Engraftment and Exploring Future Frontiers

[Life Sciences] Hypoxia-induced necrosis and delayed revascularization attenuate organoid viability and functional capacity, alleviated by the integration of diverse cell types e.g., human amniotic epithelial cells and human umbilical vein endothelial cells to boost vascularization.

Comparison Between Stem Cell Therapy and Stem Cell Derived Exosomes on Induced Multiple Sclerosis in Dogs

[Proceedings Of The National Academy Of Sciences Of The United States Of America] Dog models of multiple sclerosis received either a single treatment of stem cells or a single treatment of exosomes intrathecally and the treatment process was evaluated clinically, radiologically, histopathologically, and electron microscopy and cerebrospinal fluid analysis.

Combined Transplantation of hiPSC-NSC and hMSC Ameliorated Neuroinflammation and Promoted Neuroregeneration in Acute Spinal Cord Injury

[Current Stem Cell Research & Therapy] To evaluate the therapeutic effects of combination cells, acute spinal cord injury mice model were established and combined transplantation of hiPSC-neural stem cells and human mesenchymal stem cells into the lesion site immediately after the injury.

Deformable Smart DNA Nanomachine for Synergistic Intracellular Cancer-Related miRNAs Imaging and Chemo-Gene Therapy of Drug-Resistant Tumors

[Small] Deformable smart DNA nanomachines were developed for synergistic intracellular cancer-related miRNAs imaging and chemo-gene therapy of drug-resistant tumors.

An International Learning Collaborative Phase II Trial for Haploidentical Bone Marrow Transplant in Sickle Cell Disease

[Blood] Investigator conducted an international multicenter Phase II clinical trial testing the hypothesis that non-myeloablative related haploidentical BMT with thiotepa and post-transplant cyclophosphamide will result in two-year event-free survival of at least 80%.

PTCy Versus ATG as Graft-Versus-Host Disease Prophylaxis in Mismatched Unrelated Stem Cell Transplantation

[Blood Cancer Journal] Investigators analyzed the outcome of rabbit anti-thymocyte globulin vs. post-transplantation cyclophosphamide prophylaxis in adult patients with hematologic malignancies undergoing first peripheral blood allogeneic stem cell transplantations from mismatched unrelated donors between Jan 2018 and June 2021 in the database of the European Society for Blood and Marrow Transplantation.

A Humanized Mouse Model for Adeno-Associated Viral Gene Therapy

[Nature Communications] The authors describe a human liver chimeric transgene-free Il2rg−/−/Rag2−/−/Fah−/−/Aavr−/− (TIRFA) mouse model overcoming this translational roadblock, by combining liver humanization with AAV receptor (AAVR) ablation, rendering murine cells impermissive to AAV transduction.

Highly Bioadaptable Hybrid Conduits with Spatially Bidirectional Structure for Precision Nerve Fiber Regeneration via Gene Therapy

[Advanced Science] Researchers presented a scaffold that facilitated the localized administration of the transforming growth factor β gene in the proximal region to accelerate nerve regeneration, while simultaneously delivering nicotinamide mononucleotide adenylyltransferase 2 to the distal region to mitigate Wallerian degeneration.

[18F]FDG PET/CT for Prognosis and Toxicity Prediction of Diffuse Large B Cell Lymphoma Patients With Chimeric Antigen Receptor T Cell Therapy

[European Journal Of Nuclear Medicine And Molecular Imaging] The authors evaluated the value of [18F]fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) combining with clinical indices and laboratory indicators in predicting outcomes and toxicity of anti-CD19 CAR T-cell therapy for diffuse large B-cell lymphoma patients.

Why Is The FDA Concerned About Secondary Cancers After CAR T Cells?

[Forbes] In November, the FDA released an announcement saying it was investigating reports of secondary cancers in people with blood cancers who were treated with CAR T cells.

BioCardia Announces CMS Approval of Coverage for CardiAMP Cell Therapy Confirmatory Phase III Heart Failure Study

[BioCardia, Inc.] BioCardia, Inc. announced Centers for Medicare & Medicaid Services approval for reimbursement coverage of the confirmatory Phase III clinical trial of CardiAMP autologous cell therapy for the treatment of patients with ischemic heart failure.

Particle-Based Artificial Antigen-Presenting Cell Systems for T Cell Activation in Adoptive T Cell Therapy

[ACS Nano] Unlike other immunotherapy modalities, T cell-based adoptive cell therapy involves directly transferring engineered T cells into patients to eradicate diseased cells; hence, it necessitates methods for effectively activating and expanding T cells in vitro.

Published since 2002, Cell Therapy News is our longest running online publication. Our editorial team curates the top publications, reviews, and news on in vivo gene therapy, cell therapy, and immunotherapy research. With over 15,000 subscribers and followers across our website, email newsletter, and Twitter feed, we are proud to facilitate the communication of cutting-edge cell therapy innovations.

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