Stem Cell Discovery Could Aid In Diabetes Treatments
A University of Alberta diabetes researcher has helped uncover a possible new source of insulin for diabetics and a valuable clue in the treatment of neurological disorders.
Pancreatic stem cells can cure diabetes: Study
Toronto University scientists have said that stem cells can be a cure for diabetes, thereby eradicating the need for replacing insulin. The experiments conducted on mice, the findings of which appear in the journal Nature Biotechnology, has revealed that immature cells in the pancreas of the mice upon treatment, could be developed into cells that produce insulin. The scientists believe that their laboratory discovery will make it possible for them to generate new beta cells to cure insulin deficiency thereby making it possible to cure people afflicted with diabetes.
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Israeli cell therapy tricks immune system into fighting cancer
Forged by researchers at the Hadassah University Medical Center in Jerusalem, under the direction of Weisner Department of Bone Marrow Transplantation and Cancer Immunotherapy director and bone marrow transplantation pioneer Prof. Shimon Slavin, doctors have improved the science of training donor lymphocytes in a laboratory to act as honing devices to kill cancer cells, before being infused into a patient whose own lymphocytes are not properly doing their job.
Blajchman MA et al. Proceedings of a consensus conference: the screening of blood donors for variant CJD.
Study Finds Immune Therapy for Metastic Breast Cancer Possible
HIV-1 Nef equips dendritic cells to reduce survival and function of CD8+ T cells: a mechanism of immune evasion
Circulating myeloid and lymphoid precursor dendritic cells are clonally involved in myelodysplastic syndromes
Treatment intensity significantly influencing fibrosis in bone marrow independently of the cytogenetic response: meta-analysis of the long-term results from two prospective controlled trials on chronic myeloid leukemia
BCR-ABL transcripts are early predictors for hematological relapse in chronic myeloid leukemia after hematopoietic cell transplantation with reduced intensity conditioning
Photoimmune Therapy: Expanded Applications for Graft-versus-Host Disease
Stem Cell Research Foundation grant awards of up to $50,000 per year for two years
Application Deadline: Oct. 19, 2004
Review Article Makes Case For A New Source Of Cells In The Body
As the debate continues on the ethics and therapeutic potential of embryonic versus mature stem cells, Medical College of Georgia researchers are exploring a third group of cells that appears critical to development and capable of making all major types of human tissue.
Discovery of potential stem cells could help those suffering from diabetes
Scientists’ bioengineering feat
The man who grew a new jaw on his back
Stem Cells Put Woman’s Arthritis in Remission
Transplanting stem cells from a healthy woman to her sister with severe rheumatoid arthritis apparently cured the disease, researchers report in the journal Arthritis & Rheumatism.
Stem cells: hope and setbacks (An Overview)
At three laboratories in Boston, separated by a taxi ride of no more than 10 or 15 minutes, the world of stem cell research can be captured in all its complexity, promise and diversity.
Stem cells Infusion Hoped to Halt Hearing Loss
Timothy’s parents were told that their baby, who seemed so healthy, has Sandhoff disease, a degenerative, genetic illness that would steal his hearing, his ability to swallow and hold his head up on his own – and probably would kill him before his third birthday. But a team at Duke in Durham, N.C., led by Dr. Joanne Kurtzberg, performed an experimental stem-cell transplant that they hope will halt the disease’s progression.
Mice Stem Cells May Cure Human Deafness
Heart ‘Repair Kit’ — Stem Cells Regenerate Injured Muscle
Mayo Clinic researchers have demonstrated that stem cell therapy repairs damaged heart tissue and aids recovery after heart attack. The details of the animal-based study appear in the current issue of the American Journal of Physiology (Link
First Genetic Trust to Provide Tissue and Data Banking Systems for the Multiple Myeloma Research Consortium
The Multiple Myeloma Research Consortium announced today that First Genetic Trust (FGT) has been selected as its technology partner to provide a comprehensive information technology infrastructure for managing its tissue and data banking needs. The system will be used to manage collaborative myeloma research programs across four leading academic medical research institutions that make up the MMRC’s Member Institutions (Link
) and associated research partners.
Stem cells may help to minimise the effects of cerebral palsy
According to researchers at the University College of Georgia natural chemicals that assist healing may one day help transplanted adult stem cells integrate into an injured brain, there by helping children with cerebral palsy to recover lost function.
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TopAbstracts in Bone Marrow and PBSC Transplantation 08/12/2004 – (DGNews)
Single agent dexamethasone for pre-stem cell transplant induction therapy for multiple myeloma – (Bone Marrow Transplant)
Probiotics in Relapsing and Chronic Diarrhea – (J Pediatr Hematol/Oncol)
Low dose Thalidomide and donor lymphocyte infusion as adoptive immunotherapy after allogeneic stem cell transplantation in patients with multiple myeloma – (Blood)
Oral fluconazole for empiric treatment of prolonged Fever in neutropenic patients: prospective study in 250 consecutive patients after stem cell transplantation – (Am J Clin Oncol)
Bone metabolism in patients more than five years after bone marrow transplantation – (Bone Marrow Transplant)
Cardiac Lymphoma Successfully Treated with High Dose Chemotherapy Followed by Autologous Hematopoietic Stem Cell Transplantation
Cardiac Localization of Graft-Versus-Host Disease After Allogenic Bone Marrow Transplantation
A DGReview of :”Graft-versus-leukemia activity may overcome therapeutic resistance of chronic lymphocytic leukemia with unmutated immunoglobulin variable heavy chain gene status: implications of minimal residual disease measurement with quantitative PCR“. Blood
Parkinsons gene therapy patient well after 1 year suggesting that the therapy is safe and effective
First step in using gene therapy to treat glaucoma
Silencing Human Gene Through New Science of Epigenetics
For the first time, scientists have shown how the activity of a gene associated with normal human development, as well as the occurrence of cancer and several other diseases, is repressed epigenetically — by modifying not the DNA code of a gene, but instead the spool-like histone proteins around which DNA tightly wraps itself in the nucleus of cells in the body.
U.K. Gene therapy trial for tumours
Researchers have been given approval to carry out a large clinical trial of a new treatment for patients with an aggressive type of brain tumour.
‘Smart Gene Therapy’ Protects Against Damage From Heart Attack
Early intervention with a novel kind of “smart gene therapy” might effectively prevent the organ damage commonly suffered by heart attack victims, suggests a new animal study by researchers at Brigham and Women’s Hospital in Boston and Duke University Medical Center. The therapy combines a therapeutic gene with a genetic “sensor” that recognizes and responds to the oxygen deprivation that follows the reduced blood flow, or ischemia, from coronary artery disease and heart attack.
Progress in the Use of Adeno-Associated Viral Vectors for Gene Therapy
Cytotherapy. Volume 6, Number 4 / August 2004
Ex vivo expansion of cord blood mononuclear cells on mesenchymal stem cells
Improving the efficiency of PBPC collection by pre-apheresis peripheral blood and mid-apheresis product measurements of CD34 cells
Inhibitors of histone deacetylases promote hematopoietic stem cell self-renewal
A preliminary analysis of the balance between Th1 and Th2 cells after CD34+ cell-selected autologous PBSC transplantation
Pre-clinical development of cord blood-derived progenitor cell graft expanded ex vivo with cytokines and the polyamine copper chelator tetraethylenepentamine
Autologous transplantation: the viable transplanted CD34+ cell dose measured post-thaw does not predict engraftment kinetics better than the total CD34+ cell dose measured pre-freeze in patients that receive more than 2×106 CD34+ cells/kg
Development of a technology platform for large-scale clinical grade production of DC
Isolation of BM mesenchymal stem cells by plastic adhesion or negative selection: phenotype, proliferation kinetics and differentiation potential
Preservation of G-CSF mobilized whole blood in an automated closed hollow-fiber bioreactor system