Volume 21.23 | Jun 29

2020-29-06 | CTN 21.23
Cell Therapy News by STEMCELL Technologies
Vol. 21.23 – 29 June, 2020
TOP STORY

Oncolytic Virus-Derived Type I Interferon Restricts CAR T Cell Therapy

Investigators tested whether the inflammatory nature of oncolytic viruses and their ability to remodel the tumor microenvironment may help to recruit and potentiate the functionality of CAR T cells.
[Nature Communications]

Full Article

Getting enough cord blood HSCs for transplantation isn't easy. But she's paving the way. Watch Suzan Imren's webinar.
PUBLICATIONSRanked by the impact factor of the journal

Mybl2 Rejuvenates Heart Explant‐Derived Cells from Aged Donors after Myocardial Infarction

In vivo, scientists observed an increase in cell retention and vasculogenesis after treatment with Mybl2‐over‐expressing explant‐derived cells which improved heart function in infarcted recipient hearts.
[Aging Cell]

Full Article

Combining Timed GDNF and ChABC Gene Therapy to Promote Long‐Distance Regeneration following Ventral Root Avulsion and Repair

In rats with ventral root avulsion injuries, the authors combined timed glial cell line‐derived neurotrophic factor gene therapy delivered to the proximal nerve roots with the digestion of inhibitory CSPGs in the distal denervated nerve using sustained lentiviral‐mediated chondroitinase ABC enzyme expression.
[FASEB Journal]

Full Article

Soluble Vegfr3 Gene Therapy Suppresses Multi‐Organ Metastasis in a Mouse Mammary Cancer Model

Scientists showed that psVEGFR‐3 significantly diminished cell growth with and without added VEGF‐C in vitro, and significantly reduced primary tumor growth and tumor metastases to wide‐spectrum organs in vivo.
[Cancer Science]

Abstract

Effects of Photobiomodulation Combined with MSCs Transplantation on the Repair of Spinal Cord Injury in Rat

Investigators evaluated the therapeutic effect of human umbilical cord MSCs and laser alone or combined on spinal cord injury.
[Journal of Cellular Physiology]

Abstract

Co‐Microencapsulation of Human Umbilical Cord‐Derived Mesenchymal Stem and Pancreatic Islet‐Derived Insulin Producing Cells: A New Experimental Approach for the Cell Therapy of Type 1 Diabetes Mellitus (T1D)

Researchers grafted microencapsulated umbilical cord Wharton Jelly‐derived adult mesenchymal stem cell/human pancreatic islet‐derived progenitor cell co‐aggregates into NOD/SCID mice, and observed an acquired ability of cells to produce and store hormones.
[Diabetes-Metabolism Research and Reviews]

Abstract

Topical Administration of SLN-Based Gene Therapy for the Treatment of Corneal Inflammation by De Novo IL-10 Production

Eye drops containing biocompatible non-viral vectors based on solid lipid nanoparticles as gene delivery systems to induce the expression of interleukin 10 (IL-10) were designed to address the treatment of corneal inflammation.
[Pharmaceutics]

Full Article

Factors That Predict Delayed Platelet Recovery after Autologous Stem Cell Transplantation for Lymphoma or Myeloma

Platelet recovery following autologous stem cell transplantation (ASCT) was affected by insufficient hematopoietic recovery at stem cell harvest, a need for repeated apheresis, and high fever early after ASCT, particularly when the amount of infused stem cells was insufficient.
[Annals of Hematology]

Abstract

Co‑Transplantation of Tonsil‑Derived Mesenchymal Stromal Cells in Bone Marrow Transplantation Promotes Thymus Regeneration and T Cell Diversity following Cytotoxic Conditioning

Researchers found that the co‑transplantation of tonsil‑derived mesenchymal stromal cells (T‑MSCs) with bone marrow‑derived cells (BMCs) accelerated the recovery of involuted thymuses in mice following partial pre‑bone marrow transplantation conditioning with busulfan‑cyclophosphamide treatment, possibly by inducing FMS‑like tyrosine kinase 3 ligand and fibroblast growth factor 7 production in T‑MSCs.
[International Journal of Molecular Medicine]

AbstractFull Article

Watch this lively panel discussion about hPSC lines for cell therapies at the Nature Research Round Table on hPSC Quality
REVIEWS

Emerging Routes to the Generation of Functional β-Cells for Diabetes Mellitus Cell Therapy

Substantial advances have been made in producing mature β-cells from human pluripotent stem cells that respond appropriately to dynamic changes in glucose concentrations in vitro and rapidly function in vivo following transplantation in mice.
[Nature Reviews Endocrinology]

Abstract

Advances and Potential Pitfalls of Oncolytic Viruses Expressing Immunomodulatory Transgene Therapy for Malignant Gliomas

Scientists summarize the research advances related to oncolytic viruses that express immunomodulatory transgenes, as well as potential treatment pitfalls in patients with malignant gliomas.
[Cell Death & Disease]

Full Article

INDUSTRY AND POLICY NEWS

Avalon GloboCare Announces Successful Completion of Phase I Clinical Study of CAR T-Cell Therapy Candidate AVA-001

Avalon GloboCare Corp. announced it has successfully completed Phase I first-in-human clinical study of its leading Chimeric Antigen Receptor T-cell therapy candidate, AVA-001.
[Avalon Globocare Corp.]

Press Release

Rocket Pharmaceuticals Announces FDA Clearance of IND for RP-L401 Gene Therapy for Infantile Malignant Osteopetrosis

Rocket Pharmaceuticals, Inc. announced that it has received clearance from the FDA for the company’s Investigational New Drug application for RP-L401.
[Rocket Pharmaceuticals, Inc.]

Press Release

Lineage Cell Therapeutics Provides Update on OPC1 Cell Therapy Program for Spinal Cord Injury

Lineage Cell Therapeutics, Inc. provided an update on OPC1, the company’s oligodendrocyte progenitor cell therapy for the treatment of acute spinal cord injury.
[Lineage Cell Therapeutics, Inc.]

Press Release

FEATURED EVENT

Keystone eSymposia | Advances in Cancer Immunotherapy

August 17 – August 19
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JOB OPPORTUNITIES

Senior Scientist – Process Development Lab, Gene and Cell Therapy

Genezen Laboratories – Indianapolis, Indiana, United States

Quality Control Manager – Gene and Cell Therapy

Genezen Laboratories – Indianapolis, Indiana, United States

Scientific Project Manager – Neurofibromatosis Type 1 Gene Therapy

Gilbert Family Foundation – Detroit, Michigan, United States

Postdoctoral Fellow – Immune and Stem Cell Engineering

Terasaki Institute for Biomedical Innovation – Los Angeles, California, United States

Faculty Positions – Regenerative Medicine

Guangzhou Regenerative Medicine and Health Guangdong Laboratory – Guangzhou, China

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