Volume 16.33 | Aug 31

Issue 16.33 August 31, 2015
Cell Therapy News - Your Industry in an Instant
Your Industry in an Instant Twitter   Facebook  
Publications | Reviews | Science | Policy | Business | NIH | CBER | Regulatory | Events | Jobs
 
TOP STORY
Immunotherapy Agent Benefits Patients with Drug-Resistant Multiple Myeloma in First Human Trial
In its first clinical trial, a breakthrough antibody therapy produced at least partial remissions in a third of patients with multiple myeloma who had exhausted multiple prior treatments, investigators report. [Press release from Dana-Farber Cancer Institute discussing online publication in New England Journal of Medicine] Press Release | Abstract
Learn more about T cell activation and expansion with ImmunoCult™
 
PUBLICATIONS (Ranked by impact factor of the journal)
Genome-Wide RNAi Screening Identifies Host Restriction Factors Critical for In Vivo AAV Transduction
Researchers report the results of a high-throughput, whole-genome siRNA screening aimed at identifying cellular factors regulating adeno-associated virus (AAV) transduction. [Proc Natl Acad Sci USA] Abstract

Nerve Growth Factor Gene Therapy: Activation of Neuronal Responses in Alzheimer Disease
Investigators aimed to determine whether degenerating neurons in Alzheimer disease retain an ability to respond to a nervous system growth factor delivered after disease onset. [JAMA Neurol] Full Article | Press Release

Triggerable Degradation of Polyurethanes for Tissue Engineering Applications
Researchers report a new family of reduction-sensitive biodegradable elastomeric polyurethanes containing various amounts of disulfide bonds, in which degradation can be initiated and accelerated with the supplement of a biological product – antioxidant-glutathione. [ACS Appl Mater Interfaces] Abstract

In Vitro-Conditioned Bone Marrow-Derived Mesenchymal Stem Cells (BMSC) Promote De Novo Functional Enteric Nerve Regeneration, but Not through Direct-Transdifferentiation
Scientists demonstrated that allogeneically transplanted preconditioned BMSC initiate de novo regeneration of gastric neuronal cells/structures that in turn restore gastric contractility in pylorus-denervated rats. [Stem Cells] Abstract

Epicutaneous Immunotherapy with a Hypoallergenic Bet v 1 Suppresses Allergic Asthma in a Murine Model
Scientists investigated the efficacy of recombinant Bet v 1B2, a hypoallergenic folding variant of Bet v 1, in epicutaneous immunotherapy to suppress asthmatic features using a murine model of birch pollen allergy. [Allergy] Abstract

Insulin-Producing Endocrine Cells Differentiated In Vitro from Human Embryonic Stem Cells Function in Macroencapsulation Devices In Vivo
Enriched islet-like cells, when encapsulated and implanted into mice, functioned similarly to the VC-01 candidate product, demonstrating conclusively that in vitro-produced human embryonic stem cell-derived insulin-producing cells can mature and function in vivo in devices. [Stem Cells Transl Med] Abstract

Foxp3-Modified Bone Marrow Mesenchymal Stem Cells Promotes Liver Allograft Tolerance through the Generation of Regulatory T Cells in Rats
Scientists hypothesized that mesenchymal stem cells (MSC)-based Foxp3 gene therapy would improve immunosuppressive capacity of MSC and induce donor-specific allograft tolerance in rat’s liver allograft model. [J Transl Med] Full Article

HDAC Inhibition Upregulates PD-1 Ligands in Melanoma and Augments Immunotherapy with PD-1 Blockade
Researchers showed that class I histone deacetylase inhibitors upregulated the expression of PD-L1 and, to a lesser degree, PD-L2 in melanomas. Evaluation of human and murine cell lines and patient tumors treated with a variety of histone deacetylase (HDAC) inhibitors in vitro displayed upregulation of these ligands These results were validated in vivo in a B16F10 syngeneic murine model. [Cancer Immunol Res] Abstract

Neural Stem/Progenitor Cell-Laden Microfibers Promote Transplant Survival in a Mouse Transected Spinal Cord Injury Model
Scientists hypothesized that a neural stem/progenitor cell-microfiber combination would facilitate lesion closure as well as transplant survival in transected spinal cords. [J Neurosci Res] Abstract

It all starts with the right cells! Get Fresh Human Peripheral Whole Blood and Leuko Paks
 
REVIEWS
Alphavirus Vectors as Tools in Neuroscience and Gene Therapy
Due to the strong local transient expression provided by alphavirus vectors a number of immunization and gene therapy approaches have demonstrated both therapeutic and prophylactic efficacy in various animal models. [Virus Res] Abstract

Visit our reviews page to see a complete list of reviews in the cell, gene and immunotherapy research fields.

Request a Sample: ReproTeSR™
 
SCIENCE NEWS
Peregrine Pharmaceuticals Presents Data Supporting Ability of Bavituximab to Mediate Anti-Tumor T Cell Responses across Multiple Tumor Types
Peregrine Pharmaceuticals, Inc. announced the presentation of a range of clinical, translational and pre-clinical study results highlighting the ability of bavituximab, Peregrine’s investigational phosphatidylserine-signaling pathway inhibitor, to promote anti-tumor T cell mediated activity in several tumor types. [Press release from Peregrine Pharmaceuticals, Inc. discussing research presented at the 10th Annual Immunotherapy and Vaccine Summit (ImVacS), Boston] Press Release

Cellectis to Present Data on Its CAR T-Cell Immunotherapy Programs during Upcoming Conferences
Cellectis announced that pre-clinical data on its engineered allogeneic CAR T-cells will be featured during several conferences in the coming weeks. [Press release from Cellectis discussing research to be presented at the CRI-CIMT-EATI-AACR Immunotherapy Conference, New York] Press Release

3rd Annual Cell Culture & Bioprocessing Asia Congress 2015
 
POLICY
In Brief, Papers with Shorter Titles Get More Citations, Study Suggests
They say never judge a book by its cover, but a new study suggests that you may be able to predict the popularity of a scientific paper from the length of its title. [ScienceInsider] Editorial | Report

China Announces Stem-Cell Rules
Chinese stem-cell scientists have welcomed long-awaited measures that, state media claim, will rein in rogue use of stem cells in clinics while allowing research. [Nature News] Editorial

From our sponsor: Learn about applications of ALDHbr cells in regenerative medicine. Watch the video.
 
BUSINESS
Immatics and MD Anderson Announce Launch of Immatics US, Inc., to Develop Multiple T-Cell and TCR-Based Adoptive Cellular Therapies
Immatics Biotechnologies GmbH and The University of Texas MD Anderson Cancer Center announced the launch of Immatics US, Inc., a new company aiming at becoming a global leader in adoptive cellular therapies for the treatment of a range of tumor types. [The University of Texas MD Anderson Cancer Center] Press Release

MorphoSys and Immatics Biotechnologies Enter Strategic Alliance in Immuno-Oncology
MorphoSys AG and Immatics Biotechnologies GmbH announced a strategic alliance to generate novel antibody-based therapeutics against multiple proprietary cancer antigens recognized by T cells. [MorphoSys AG] Press Release

Ocata Therapeutics Receives SBIR Grant from NIH to Develop Proprietary Hemangio-Derived Mesenchymal Cell Therapy for Lupus Nephritis
Ocata Therapeutics, Inc. announced that it has been awarded a Small Business Innovation Research (SBIR) Phase I grant from the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health (NIH), to fund further preclinical development of Ocata’s proprietary hemangio-derived mesenchymal cell product for the treatment of systemic lupus erythematosus and lupus nephritis. [Ocata Therapeutics, Inc.] Press Release

NIH Awards Nearly $34 Million to UAB Center for Clinical and Translational Science
The National Institutes of Health (NIH) has awarded the University of Alabama at Birmingham (UAB) Center for Clinical and Translational Science $33.59 million over four years to continue the center’s programs advancing translational research. [University of Alabama at Birmingham] Press Release

TxCell Consortium Granted €1.28 Million for TRUST Project on Process and Clinical Development of Col-Treg for Autoimmune Uveitis Treatment
TxCell SA announced that the French government’s Unique Interministerial Fund (FUI) has granted €1.28 million to the TRUST project (TRegs in Uveitis STudy). The FUI panel awarded the TRUST funding application the highest score, and as a result, the project qualified for the maximum percentage of funding from the French government. [TxCell SA] Press Release

Diabetes Research Institute Successfully Transplants First Patient in Pilot BioHub Trial
The Diabetes Research Institute, a Center of Excellence at the University of Miami Miller School of Medicine, announced that the first patient in its clinical trial to test for the first time a novel transplant technique for insulin-producing cells was successfully completed. [The Diabetes Research Institute] Press Release

NW Bio Confirms Phase III Trial of DCVax®-L for GBM Brain Cancer Is Ongoing
Northwest Biotherapeutics confirmed that its Phase III trial of DCVax®-L for newly diagnosed glioblastoma multiforme (GBM) is ongoing and the patients enrolled in the trial are continuing to be treated per the protocol. [Northwest Biotherapeutics] Press Release

Cell Therapy Catapult Welcomes Planning Decision for Manufacturing Center
The Cell Therapy Catapult has welcomed the decision by Stevenage Borough Council to grant planning permission to construct its £55 million large-scale GMP manufacturing center. [Cell Therapy Catapult] Press Release
 
NIH
Center for Scientific Review; Notice of Closed Meetings (FR Doc. No: 2015-20919)
 
CBER
Nonproprietary Naming of Biological Products; Draft Guidance for Industry
 
REGULATORY
Food and Drug Administration (United States)

Designation of Official Names and Proper Names for Certain Biological Products (FR Doc. No: 2015-21382)

Design and Analysis of Shedding Studies for Virus or Bacteria-Based Gene Therapy and Oncolytic Products; Guidance for Industry; Availability (FR Doc. No: 2015-21235)
 
EVENTS
Stem Cell Meeting on the Mesa
October 7-9, 2015
La Jolla, United States


Visit our events page to see a complete list of events in the cell, gene and immunotherapy community.
 
JOB OPPORTUNITIES
NEW Cellular Therapy Lab Technologies (Fred Hutchinson Cancer Research Center)

NEW Postdoctoral Position – Spinal Cord Injury Research (Indiana University-Purdue University)

Postdoctoral Fellow – HMGA Chromatin Remodeling Proteins in Cancer and Stem Cell Biology (Johns Hopkins University School of Medicine)

Senior Research Technician (Qu Biologics Inc.)

Postdoctoral Fellow Position – Genome Editing, Synthetic Biology, and Cell Evolution and Engineering (University of California – Irvine)

Research Associate – Cell Biology (Editas Medicine)

Senior Research Associate (Editas Medicine)

Postdoctoral Fellow – Biotechnology (Qu Biologics Inc.)

Cell Biology Lab Manager (Harvard Apparatus Regenerative Technology)

Science Writer – Cardiovascular Regeneration (Houston Methodist Research Institute)

PhD Studentship – Veterinary and Animal Sciences (University of Milan)

Aseptic Manufacturing Associate (Lonza Biologics, Inc.)

Postdoctoral Fellow – Stem Cell Biology (INSERM)


Recruit Top Talent: Reach more than 60,000 potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.