Volume 14.42 | Oct 28

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TOP STORY
Reduced-Intensity Conditioning and HLA-Matched Hemopoietic Stem-Cell Transplantation in Patients with Chronic Granulomatous Disease: A Prospective Multicenter Study
In chronic granulomatous disease allogeneic hemopoietic stem-cell transplantation in adolescents and young adults and patients with high-risk disease is complicated by graft-failure, graft-versus-host disease, and transplant-related mortality. Researchers examined the effect of a reduced-intensity conditioning regimen designed to enhance myeloid engraftment and reduce organ toxicity in these patients. [Lancet]
Abstract | Press Release
Your Free Copy of the Nature Neuroscience Poster 'Neural Stem Cells' Awaits
 
PUBLICATIONS (Ranked by impact factor of the journal)
Human Induced Pluripotent Stem Cell-Derived Cortical Neurons Integrate in Stroke-Injured Cortex and Improve Functional Recovery
At two months after transplantation into a stroke-damaged rat cortex, cortically fated cells showed less proliferation and more efficient conversion to mature neurons with morphological and immunohistochemical characteristics of a cortical phenotype and higher axonal projection density as compared with non-fated cells. [Brain] Abstract | Press Release

Inhibition of Plasminogen Activator Inhibitor Type-1 Activity Enhances Rapid and Sustainable Hematopoietic Regeneration
Genetic disruption of the plasminogen activator inhibitor-1 (PAI-1) gene, or pharmacological inhibition of PAI-1 activity, significantly improved the myeloablation-related mortality and promoted rapid hematopoietic recovery after hematopoietic stem cell transplantation through the induction of hematopoiesis-promoting factors. [Stem Cells] Abstract

WKYMVm-Induced Activation of Formyl Peptide Receptor 2 Stimulates Ischemic Neovasculogenesis by Promoting Homing of Endothelial Colony Forming Cells
Researchers investigated the effects of WKYMVm, a selective formyl peptide receptor 2 agonist isolated by screening synthetic peptide libraries, on homing ability of endothelial colony forming cells and vascular regeneration of ischemic tissues. [Stem Cells] Abstract

TRIM5α Variations Influence Transduction Efficiency with Lentiviral Vectors in Both Human and Rhesus CD34+ Cells In Vitro and In Vivo
Investigators examined whether TRIM5α could account for variations in transduction efficiency using both an established rhesus gene therapy model and human CD34+ cell culture. Evaluation of TRIM5α genotypes (Mamu-1, -2, -3, -4, -5, and TrimCyp) in 16 rhesus macaques that were transplanted with transduced CD34+ cells showed a significant correlation between TRIM5α Mamu-4 and high gene marking in both lymphocytes and granulocytes six months after transplantation. [Mol Ther] Abstract

Stem Cells Derived from Tooth Periodontal Ligament Enhance Functional Angiogenesis by Endothelial Cells
In comparison to mesenchymal stem cells and stem cells derived from tooth pulp tissues, researchers determined if periodontal ligament of teeth stem cells (PDLSCs) released soluble pro-angiogenic factors with the capacity to induce vessel formation by endothelial cells (ECs). Next, the ability of PDLSCs to modulate angiogenesis was examined through their co-transplantation with ECs in subcutaneous sites of immunocompromised mice. [Tissue Eng Part A] Abstract

Transplantation of Insulin-Secreting Cells Differentiated from Human Adipose Tissue-Derived Stem Cells into Type 2 Diabetes Mice
Investigators evaluated the efficacy of cell therapy using insulin-secreting cells differentiated from human eyelid adipose tissue-derived stem cells into type 2 diabetes mice. [Biochem Biophys Res Commun] Abstract

Mesenchymal Stem Cells and Endothelial Progenitor Cells Stimulate Bone Regeneration and Mineral Density
Researchers quantified extra-cortical bone augmentation and tissue mineral density following co-transplantation of peripheral blood derived endothelial progenitor cells and bone marrow derived mesenchymal stem cells by micro computed tomography. [J Periodontol] Abstract

Improved Preparation of Acellular Nerve Scaffold and Application of PKH26 Fluorescent Labeling Combined with In Vivo Fluorescent Imaging System in Nerve Tissue Engineering
Scientists prepared a novel acellular nerve scaffold by the technique of hypotonic buffer combined with freeze-drying, and used PKH26 fluorescent labeling combined with an in vivo fluorescent imaging system to evaluate the biological behavior of tissue-engineered nerves in vitro and in vivo. [Neurosci Lett] Abstract

mTORC1 Targets the Translational Repressor 4E-BP2, but Not S6 Kinase 1/2, to Regulate Neural Stem Cell Self-Renewal In Vivo
Researchers found that genetically decreasing mammalian target of rapamycin complex 1 (mTORC1) activity in neonatal neural stem cells prevented their differentiation, resulting in reduced lineage expansion and aborted neuron production. [Cell Rep] Full Article | Graphical Abstract | Press Release

Find protocols, tools and video at the Human Immunology Portal
 
REVIEWS
Mesenchymal Stem Cells Improve Locomotor Recovery in Traumatic Spinal Cord Injury: Systematic Review with Meta-Analyses of Rat Models
Investigators performed a systematic review with quantitative syntheses to assess the evidence of mesenchymal stem or stromal cells versus controls for locomotor recovery in rat models of traumatic spinal cord injury, and identified 83 eligible controlled studies comprising a total of 1,568 rats. [Neurobiol Dis] Abstract

Key Action Items for the Stem Cell Field: Looking Ahead to 2014
Looking ahead to 2014, both the challenges and opportunities for the stem cell field require a proactive, thoughtful approach to maximize the potential for a positive impact from stem cell advances. The author discusses the key action items for the field as scientists look ahead to the coming year and beyond. [Stem Cell Dev] Abstract | Press Release

Concise Review: Stem Cell Therapy for Muscular Dystrophies
The authors review the current state of research on myogenic stem cells and identify the important challenges that must be addressed as stem cell therapy is brought to the clinic. [Stem Cells Transl Med] Abstract

Visit our reviews page to see a complete list of reviews in the cell, gene and immunotherapy research field.

New Cord Banking Software Solution from STEMSOFT
 
SCIENCE NEWS
Sangamo BioSciences Presents Clinical Data from HIV Study Demonstrating Sustained Control of Viremia
Sangamo BioSciences, Inc. announced the presentation of new data demonstrating sustained control of HIV viral load at or below the limit of detection for 14 weeks (at last measurement) in an SB-728-T- treated HIV-infected subject who was not on antiretroviral therapy (ART). [Press release from Sangamo BioSciences, Inc. discussing research presented at the Annual Meeting of the European Society of Gene and Cell Therapy (ESGCT), Madrid] Press Release

Juventas Therapeutics Completes Enrollment of Phase II STOP-HF Study of JVS-100 in Patients with Symptomatic Heart Failure
Juventas Therapeutics announced that the company has completed enrollment of the STOP-HF trial. STOP-HF is a double-blinded, placebo-controlled, multi-center trial of its non-viral DNA plasmid therapy JVS-100 for patients with symptomatic heart failure. [PR Newswire Association LLC] Press Release

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POLICY
NIH Reverses Course, Will Move Up Peer-Review Meetings
Responding to an outcry from researchers, the National Institutes of Health (NIH) has revised its plan to delay more than 200 grant application review meetings canceled by the 1 to 16 October government shutdown. [ScienceInsider] Editorial

India’s Supreme Court Mandates Videotaped Consent in Clinical Trials
The Indian Supreme Court ordered the central government to issue regulations mandating videotaped informed consent of all participants in any clinical trial conducted on Indian soil, as well as additional cost-benefit analyses of potential drugs before trials can proceed. [ScienceInsider] Editorial

U.N. Names New Science Advisory Board
U.N. Secretary-General Ban Ki-moon has appointed 26 scientists to a new Scientific Advisory Board that will provide the global body advice on “science, technology and innovation … for sustainable development.” [ScienceInsider] Editorial
 
BUSINESS
STEMSOFT Licenses StemLab Software to TUMCells
STEMSOFT™ Software Inc. (STEMSOFT) announced the licensing of StemLab™, the leading cell therapy transplant laboratory software, to TUMCells Interdisziplinäres Zentrum für zelluläre Therapien Technische Universität München (TUMCells) at the University Hospital Klinikum rechts der Isar in Germany. [STEMSOFT Software Inc.] Press Release

PharmaCell Announces Agreement to Be – The European Contract Manufacturing Organization for Dendreon
PharmaCell announced that it has entered into an agreement with Dendreon Corporation to be the Contract Manufacturing Organization for the European commercial production of its recently approved cellular immunotherapy product Provenge® (autologous peripheral blood mononuclear cells activated with PAP-GM-CSF or sipuleucel-T) dispersion for infusion. [PharmaCell B.V.] Press Release

Bioheart Announces Agreement with Anosis to Distribute Products in the Middle East
Bioheart, Inc., a biotech company focused on the discovery, development and commercialization of autologous cell therapies for the treatment of chronic and acute heart damage as well as severe peripheral vascular disease announces that it has entered into an agreement with Anosis, a company organized in Turkey. According to the distribution agreement, Anosis will distribute Bioheart therapies in Turkey, Azerbaijan, Kazakhstan, Turkmenistan, Georgia and Iraq. [Bioheart, Inc.] Press Release

Medical Research Council Award Puts Bristol on the Map for Regenerative Medicine Imaging
A research team at the University of Bristol have been awarded £2.77 million that could fast-track the progression of new discoveries in stem cell research from the lab to the bedside of the NHS and benefit patients in the future. [University of Bristol] Press Release

The Leukemia & Lymphoma Society Announces Recipients of the New Idea Award Grant Program
The Leukemia & Lymphoma Society announced the researchers who will receive The New Idea Award – a grant program designed to identify novel research strategies with high potential for significant impact on the future of blood cancer treatments. [The Leukemia & Lymphoma Society] Press Release

BioTime Reports Interim Results on Renevia™ Clinical Safety Trial
BioTime, Inc. announced that William Tew, Ph.D., will provide an update on the development of Renevia™ at an investor meeting in New York City. In his presentation, Dr. Tew will announce that enrollment in a safety trial evaluating Renevia™, a proprietary injectable matrix designed to facilitate the stable engraftment of transplanted cells, is complete. [BioTime, Inc.] Press Release

Mesoblast Updates Market on Registration Plans for GvHD Cell Product in Japan
Mesoblast Limited updated the market on product registration plans in Japan for its proprietary culture-expanded Mesenchymal Stem Cells (MSCs) in the treatment of steroidrefractory graft-versus-host disease (GvHD). Under a collaborative agreement, JCR Pharmaceuticals Co. Ltd. has exclusive rights in Japan to manufacture, develop and market Mesoblast’s culture-expanded MSCs in connection with the use of hematopoietic stem cells derived from peripheral blood, cord blood or bone marrow in the treatment of hematological malignancies. [Mesoblast Limited] Press Release

UW Expands Stem Cell Research to Waisman Center
Stem cell researchers at the University of Wisconsin’s (UW’s) Waisman Center hope their ongoing work will eventually allow them to move into human clinical trials to treat degenerative illnesses such Parkinson’s disease and Down syndrome. [University of Wisconsin] Press Release
 
NIH
Center for Scientific Review; Amended Notice of Meeting (FR Doc No: 2013-25034)

National Institute of Allergy and Infectious Diseases; Notice of Closed Meetings (FR Doc No: 2013-25031)

National Institute of Biomedical Imaging and Bioengineering; Notice of Closed Meeting (FR Doc No: 2013-25032)

Submission for OMB Review; 30-Day Comment Request; Application for the Postdoctoral Research Associate Program (FR Doc No: 2013-24997)
 
CBER
Draft Guidance for Industry: Use of Nucleic Acid Tests to Reduce the Risk of Transmission of West Nile Virus from Donors of Human Cells, Tissues, and Cellular and Tissue-Based Products (HCT/Ps)
 
REGULATORY
Food and Drug Administration (United States)

Clinical Investigator Training Course (FR Doc No: 2013-25127)

Meta-Analyses of Randomized Controlled Clinical Trials (RCTs) for the Evaluation of Risk To Support Regulatory Decisions; Notice of Public Meeting; Request for Comments (FR Doc No: 2013-24939)

European Medicines Agency (European Union)

Meeting Highlights from the Committee for Medicinal Products for Human Use (CHMP) 21-24 October 2013
 
EVENTS
NEW Simplify Your Cellular Therapy Lab Processes
October 31, 2013 11:00 AM (CST)
Webinar


NEW The Activated Egg 2013
November 8, 2013 8:50 AM (EST)
Webinar


NEW Cell Therapies for Parkinson’s Disease Webinar
November 14, 2013 10:00 AM (PST)
Webinar


Visit our events page to see a complete list of events in the cell, gene and immunotherapy community.
 
JOB OPPORTUNITIES
NEW Postdoctoral Positions – Stem Cell, Cancer Biology, Immunology and Bioengineering (UC Irvine)

Faculty Position – Stem Cell Biology (University of Notre Dame)

Postdoctoral Position – Stem Cells Research (University of Maryland Baltimore)

Assistant Professorships – Stem Cells and Regenerative Medicine (Keck School of Medicine)

Postdoctoral Research Fellow – Stem Cells (Bioprocessing Technology Institute)

Postdoctoral Research Fellow – Human Induced Pluripotent Stem Cell Research (Bioprocessing Technology Institute)

Manufacturing Manager (StemCells Inc.)

Process Development Manager (StemCells Inc.)

Manufacturing Associate (StemCells Inc.)

Postdoctoral Position – Development of Cell Delivery Systems in Bone Repair (Fujifilm)

Scientist – Particle Chemistry (STEMCELL Technologies Inc.)

Research Technologist – Human Pluripotent Stem Cell Products (STEMCELL Technologies Inc.)

Research Associate/Scientist – Antibodies Group (STEMCELL Technologies Inc.)

Research Associate – Particle Chemistry (STEMCELL Technologies Inc.)


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