Volume 14.41 | Oct 21

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TOP STORY
Stem Cell Transplant Repairs Damaged Gut in Mouse Model of Inflammatory Bowel Disease
A source of gut stem cells that can repair a type of inflammatory bowel disease when transplanted into mice has been identified by researchers at the Wellcome Trust-Medical Research Council Cambridge Stem Cell Institute at the University of Cambridge and at BRIC, the University of Copenhagen, Denmark. [Press release from Wellcome Trust discussing research published in Cell Stem Cell]
Press Release | Full Article | Graphical Abstract
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PUBLICATIONS (Ranked by impact factor of the journal)
Renal Cells from Spermatogonial Germline Stem Cells Protect against Kidney Injury
Using a novel renal epithelial differentiation protocol, scientists obtained germline cell-derived pluripotent stem cell-derived tubular-like cells (GTCs) that were functional in vitro, as demonstrated through transepithelial electrical resistance analysis. In mice, GTCs injected after ischemic renal injury homed to the renal parenchyma, and GTC-treated mice showed reduced renal oxidative stress, tubular apoptosis, and cortical damage and upregulated tubular expression of the antioxidant enzyme hemeoxygenase-1. [J Am Soc Nephrol] Abstract

Epicardial Delivery of Collagen Patches with Adipose-Derived Stem Cells in Rat and Minipig Models of Chronic Myocardial Infarction
Investigators examined whether transplantation of collagen patches seeded with adipose-derived stem cells could enhance cell engraftment and improve cardiac function in models of chronic myocardial infarction. [Biomaterials] Abstract

Vasculogenesis in Experimental Stroke after Human Cerebral Endothelial Cell Transplantation
Adult rats were exposed to transient occlusion of the middle cerebral artery and three hours later randomly stereotaxically transplanted with 100K, 200K, or 400K human cerebral endothelial cell six viable cells or vehicle. Animals underwent neurological examination and motor test up to day seven after transplantation then euthanized for immunostaining against neuronal, vascular, and specific human antigens. [Stroke] Abstract

SLIT3-ROBO4 Activation Promotes Vascular Network Formation in Human Engineered Tissue and Angiogenesis In Vivo
By utilizing two functionally distinct human mesenchymal stem cell (MSC) clones, researchers found that so-called “pericytic” MSCs secrete the pro-angiogenic vascular guidance molecule SLIT3, which guides vascular development by directing ROBO4-positive endothelial cells to form networks in engineered tissue. [J Mol Cell Cardiol] Full Article | Press Release

Gene Expression Changes in the Injured Spinal Cord Following Transplantation of Mesenchymal Stem Cells or Olfactory Ensheathing Cells
Researchers analyzed the changes in the spinal cord transcriptome after a contusion injury and mesenchymal stromal cell or olfactory ensheathing cell transplantation. [PLoS One] Full Article

Insult-Dependent Effect of Bone Marrow Cell Therapy on Inflammatory Response in a Murine Model of Extrapulmonary Acute Respiratory Distress Syndrome
Investigators evaluated the effects of bone marrow-derived mononuclear cells in two models of extrapulmonary acute respiratory distress syndrome once lung morphofunctional changes had already been installed. [Stem Cell Res Ther] Abstract | Full Article

Double Suicide Gene Therapy Using Human Neural Stem Cells against Glioblastoma: Double Safety Measures
Researchers investigated the feasibility of treating glioblastomas with neural stem cells (NSCs) expressing double prodrug enzymes cytosine deaminase and tyrosine kinase to eliminate the NSCs following treatment for safety purposes. [J Neurooncol] Abstract

Inhibitory Effect and Mechanism of Mesenchymal Stem Cells on Liver Cancer Cells
Scientists investigated the inhibitory effect and mechanism of mesenchymal stem cells on human hepatoma HepG2 cells using co-culture and conditioned medium system and animal transplantation model. [Tumour Biol] Abstract

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REVIEWS
Improving Survival and Efficacy of Pluripotent Stem Cell-Derived Cardiac Grafts
This review presents an overview of the current strategies for optimizing cell and host tissue to improve the survival and efficacy of cardiac cells derived from pluripotent stem cells. [J Cell Mol Med] Full Article

Visit our reviews page to see a complete list of reviews in the cell therapy, gene therapy and immunotherapy research fields.

Video Protocol: Mucociliary Differentiation of Primary Bronchial Epithelial Cells
 
SCIENCE NEWS
International Stem Cell Corporation Announces New Data from Parkinson’s Disease Program
Results showed that neural stem cells migrate a significant distance from the site of implantation in the striatum to the substantia nigra where the loss of dopaminergic neurons primarily occurs in Parkinson’s patients. [Press release from International Stem Cell Corporation discussing research presented at the American Neurological Association’s 2013 Annual Meeting, New Orleans] Press Release

TotipotentRX & ThermoGenesis Case Study Demonstrates Autologous Stem Cell Product Safely Treats Primary Heart Attack in 60 Minute Clinical Procedure
TotipotentRX Corporation and ThermoGenesis Corp. reported a study confirming TotipotentRX’s acute myocardial infarction combination product utilizing ThermoGenesis’ point-of-care cell processing technology for an autologous bone marrow derived stem cell therapy can be delivered safely in 60 minutes. [Press release from GlobeNewswire discussing research presented at the American Association of Blood Banks Annual Meeting, Denver] Press Release

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POLICY
NIH Scrambles to Catch Up after U.S. Shutdown
Grants staff members at the National Institutes of Health (NIH) who came back to work after the 16-day government shutdown ended will now need to catch up on a backlog of research proposals and canceled peer-review meetings. Exactly how all this will play out isn’t yet clear, and angst is rising in the blogosphere about how researchers seeking new funding for their projects will be affected. [ScienceInsider] Editorial

NSF Asks Scientists to Give It Time to Regroup after Shutdown
No advisory committee meetings for the rest of the year. No review panels until November. And don’t call us just yet. That’s the guidance to the research community from the National Science Foundation (NSF), which reopened after the 16-day government shutdown. [ScienceInsider] Editorial

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BUSINESS
CIRM Director Steps Down
Alan Trounson, the Australian researcher who has headed California’s $3 billion stem cell institute for nearly six years, is stepping down to be closer to his family. [ScienceInsider] Editorial

HBIO Announces Details of Approved Spin-Off of Harvard Apparatus Regenerative Technology, Inc.
The Board of Directors of Harvard Bioscience, Inc. (HBIO) has approved the spin-off of its wholly owned regenerative medicine device subsidiary, Harvard Apparatus Regenerative Technology, Inc. [Harvard Bioscience, Inc.] Press Release

Stem Cell Therapeutics Strengthens CD47 Franchise with Acquisition of Complementary Antibody Program
Stem Cell Therapeutics Corp. announced that it has entered into an option agreement to exclusively license worldwide rights to a panel of fully human monoclonal antibodies targeting the SIRPa protein. [Stem Cell Therapeutics Corp.] Press Release

Einstein and Montefiore Receive $25 Million NIH Grant to Support Clinical and Translational Research
Albert Einstein College of Medicine of Yeshiva University and Montefiore Medical Center have received a $25 million grant from the National Institutes of Health (NIH) for the Harold and Muriel Block Institute for Clinical and Translational Research at Einstein and Montefiore. The two institutions received their initial Clinical and Translational Science Award from the NIH in 2008 to launch this joint collaboration. [Albert Einstein College of Medicine] Press Release

New York Stem Cell Foundation Announces $10.5 Million to Seven New NYSCF-Robertson Investigators
The New York Stem Cell Foundation (NYSCF) named seven of the most promising scientists as its 2013 NYSCF – Robertson Investigators. Each Investigator will receive a $1.5 million award, which will be disbursed over the next five years, which will enable them to expand their laboratories and train other scientists. [The New York Stem Cell Foundation] Press Release

CASIS Announces Grant Awards for Stem Cell Research
The Center for the Advancement of Science in Space (CASIS), the nonprofit organization responsible for managing and promoting research aboard the International Space Station U.S. National Laboratory, has announced grant awards for seven researchers focused on non-embryonic stem cell biology. The award amounts total over $2 million. [The Center for the Advancement of Science in Space] Press Release

New Jersey Health Foundation Awards $50,000 Grant for Research to Facilitate Stem Cell Growth
Dr. Steven Levison has received a $50,000 Innovation Stage Funding Grant from New Jersey Health Foundation to advance research that could make stem cell growth easier and less expensive for researchers, scientists and others interested in using stem cells to advance medical studies. [PR Newswire Association LLC] Press Release

Osiris and FDA Reach Agreement on Regulatory Pathway for Biosurgery Products
Osiris Therapeutics, Inc. announced that it has reached agreement with the United States Food and Drug Administration (FDA) regarding the regulatory pathway for its Biosurgery products, Grafix® and Ovation®. After discussions with the FDA, the regulatory status of Grafix is confirmed and the product will remain on the market as a wound cover for the treatment of acute and chronic wounds. For certain expanded indications for Grafix, Osiris has committed to submit a Biologics License Application. [Osiris Therapeutics, Inc.] Press Release

Cellular Dynamics Issued U.S. Patent Covering Differentiation of iPS Cells Into Endothelial, Hematopoietic Cells
Cellular Dynamics International announced that the U.S. Patent and Trademark Office issued Patent No. 8,557,580 entitled “Methods and Compositions for the Differentiation of Stem Cells”. The newly issued patent relates to the method by which induced pluripotent stem (iPS) cells are differentiated into the diverse types of endothelial and hematopoietic cells. [Cellular Dynamics International] Press Release
 
EVENTS
NEW Genetic Engineering of Mammalian Stem Cells
Cambridge, United Kingdom
March 10-22, 2014


Visit our events page to see a complete list of events in the cell, gene and immunotherapy community.
 
JOB OPPORTUNITIES
NEW Faculty Position – Stem Cell Biology (University of Notre Dame)

Postdoctoral Position – Stem Cells Research (University of Maryland Baltimore)

Assistant Professorships – Stem Cells and Regenerative Medicine (Keck School of Medicine)

Postdoctoral Research Fellow – Stem Cells (Bioprocessing Technology Institute)

Postdoctoral Research Fellow – Human Induced Pluripotent Stem Cell Research (Bioprocessing Technology Institute)

Manufacturing Manager (StemCells Inc.)

Process Development Manager (StemCells Inc.)

Manufacturing Associate (StemCells Inc.)

Postdoctoral Position – Development of Cell Delivery Systems in Bone Repair (Fujifilm)

Postdoctoral Fellow – Stem Cell Research (Tsinghua University Graduate School at Shenzhen)

Postdoctoral Position – Leukemia Biology (Northwestern University)

Cellular Therapy Lab Specialist (University of Texas Medical School at Houston)

Scientist – Particle Chemistry (STEMCELL Technologies Inc.)

Research Technologist – Human Pluripotent Stem Cell Products (STEMCELL Technologies Inc.)

Research Technologist – Cell Culture Media & Matrices (STEMCELL Technologies Inc.)

Research Associate/Scientist – Antibodies Group (STEMCELL Technologies Inc.)

Research Associate – Particle Chemistry (STEMCELL Technologies Inc.)


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