Volume 14.40 | Oct 14

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Publications | Reviews | Science | Policy | Business | Events | Jobs
TOP STORY
Cellular Encapsulation Enhances Cardiac Repair
Human mesenchymal stem cells were encapsulated in alginate and attached to the heart with a hydrogel patch in a rat myocardial infarction model. Cells were tracked using bioluminescence and cardiac function measured by transthoracic echocardiography and cardiac magnetic resonance imaging. [J Am Heart Assoc]
Full Article | Press Release
A New System for High-Throughput Cell Isolation Directly from Whole Blood
PUBLICATIONS (Ranked by impact factor of the journal)
The Effect of Encapsulation of Cardiac Stem Cells within Matrix-Enriched Hydrogel Capsules on Cell Survival, Post-Ischemic Cell Retention and Cardiac Function
Investigators explored the effect of single cell microencapsulation to increase cardiac stem cell engraftment and survival after myocardial injection. [Biomaterials] Abstract

Therapeutic Efficacy of Human Embryonic Stem Cell-Derived Endothelial Cells in Humanized Mouse Models Harboring a Human Immune System
The generation of humanized mice harboring a human immune system has provided a tool to perform in vivo immunologic studies of human cells and tissues. Using this model, scientists examined the therapeutic potential of human embryonic stem cell-derived endothelial cells, human embryonic fibroblasts, and cord blood-derived endothelial progenitor cells in a human immune system environment. [Arterioscler Thromb Vasc Biol] Abstract

Development of a Coordinated Allo T-Cell and Auto B-Cell Response against Autosomal PTK2B after Allogeneic Hematopoietic Stem Cell Transplantation
The authors previously identified LB-PTK2B-1T as HLA class II restricted polymorphic antigen in a patient treated with donor lymphocyte infusion for relapsed chronic myeloid leukemia after HLA-matched alloSCT. Since PTK2B has also been described as antibody target, they investigated whether a coordinated T- and B-cell response against PTK2B was induced. [Haematologica] Abstract | Full Article

Human Adipose Stem Cells Cell Sheet Constructs Impact Epidermal Morphogenesis in Full-Thickness Excisional Wounds
Human adipose derived stem cells (hASCs) cell sheets (CS) were obtained within five days using both thermoresponsive and standard cell culture surfaces. hASCs-based constructs were then built by superimposing three CS and transplanted into full-thickness excisional mice skin wounds with delayed healing. [Biomacromolecules] Abstract

Selective Antitumor Effect of Neural Stem Cells Expressing Cytosine Deaminase and Interferon-Beta against Ductal Breast Cancer Cells in Cellular and Xenograft Models
Investigators employed human neural stem cells transduced with genes expressing Escherichia coli cytosine deaminase and human interferon-beta as a treatment strategy for ductal breast cancer. [Stem Cell Res] Abstract

The Graft of Autologous Adipose-Derived Stem Cells in the Corneal Stromal after Mechanic Damage
Researchers explored the feasibility of using autologous rabbit adipose derived stem cells as seed cells and polylactic-co-glycolic acid as a scaffold for repairing corneal stromal defects. [PLoS One] Full Article

Adipose-Derived Cell Construct Stabilizes Heart Function and Increases Microvascular Perfusion in an Established Infarct
The authors previously showed that myocardial infarction immediately treated with an epicardial construct containing stromal vascular fraction (SVF) from adipose tissue preserved microvascular function and left ventricle contractile mechanisms. In order to evaluate a more clinically relevant condition, they investigated the cardiac recovery potential of an SVF construct implanted onto an established infarct. [Stem Cell Transl Med] Abstract | Press Release

New Cord Banking Software Solution from STEMSOFT
REVIEWS
The Application of Induced Pluripotent Stem Cells for Bone Regeneration: Current Progress and Prospects
Scientists summarize the primary technologies for generating induced pluripotent stem cells and the biological properties of these cells, review the current advances in induced pluripotent stem cell-based bone regeneration and, finally, discuss the remaining challenges associated with these cells, particularly safety issues and their potential application for osteoregenerative medicine. [Tissue Eng Part B] Abstract

Visit our reviews page to see a complete list of reviews in the cell, gene and immunotherapy research field.

Take the 'if' out of 'diff' - reduce variability when differentiating with STEMdiff™
SCIENCE NEWS
Amniotic Stem Cells Show Promise in Helping to Repair Cardiac Birth Defects
Researchers have begun testing an alternative to embryonic stem cells that could one day regenerate muscle tissue for babies with congenital heart defects. A research-in-progress report on this new approach, which uses amniotic stem cells, was presented. [Press release from EurekAlert! discussing research presented at the 2013 Clinical Congress of the American College of Surgeons, Washington DC] Press Release

ALS Stem Cell Trial Begins at U-M Health System with First Two Patients Receiving Injections
Two patients with amyotrophic lateral sclerosis (ALS) have received stem cell injections to their spinal cords at the University of Michigan (U-M) Health System – the first two to receive the experimental injections in Michigan as part of a national clinical trial. [University of Michigan] Press Release

Attend World Stem Cell Summit 2013 in San Diego! Your Window to the World of Regenerative Medicine.
POLICY
Minister Halts Italian Stem-Cell Therapy Trial
The clinical trial of a controversial stem-cell therapy supported by the Italian government has been stopped before recruiting any patients – to the relief of scientists who have been fighting the trial for months. On 10 October, health minister Beatrice Lorenzin announced that she would follow the advice of a special panel of scientific advisors and disallow the trial. [Nature News] Editorial

New Relief for Regenerative Medicine Accidents
The Health, Labor and Welfare Ministry will introduce a new system of relief for people who suffer unpredictable side effects or infection following treatment with regenerative medicine technology, such as cell sheets. [The Japan News] Editorial

Stem Cell Rules Clear, Adequate, Says Philippines FDA
The Philippines Food and Drug Administration (FDA) said its guidelines governing stem cell therapy in the country are adequate and clear, including the registration of products, health facilities and ethics review. [Manila Bulletin] Editorial

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BUSINESS
360ip and CCRM Join Forces to Source Best Intellectual Property in Regenerative Medicine
360ip and the Canadian Centre for Commercialization of Regenerative Medicine (CCRM) are signing a collaboration agreement to work together in a variety of areas, including developing a fund to invest in best-in-class regenerative medicine technologies and companies in Asia, Europe and North America. [MarketWire LP] Press Release

Scotland Demonstrates Its Collaborative Approach to Cell Therapy Development
Scotland announced that Sistemic and Roslin Cells are going to work together with Scottish Development International to make the process of undertaking clinical trials in cell therapy easier, faster and more successful in reaching commercial realization. [PR Newswire Association LLC] Press Release

Instron Forms Strategic Partnership in Regenerative Medicine
Instron is collaborating with Dr. Julie Phillippi & Dr. Thomas Gleason at the McGowan Institute for Regenerative Medicine at the University of Pittsburgh. With their research focused on understanding the cellular and molecular mechanisms of ascending aortic aneurysms in patients with bicuspid aortic valve and other heritable disorders, Instron TGT will be providing the instrumentation and mechanical environment to develop a model and evaluate the diseased state in vitro. [Illinois Tool Works Inc.] Press Release

Mesoblast Acquires Osiris’ Culture Expanded Stem Cell Therapeutic Business
Mesoblast Limited announced the acquisition of the entire culture-expanded mesenchymal stem cell business of Osiris Therapeutics by the Mesoblast Group. [GlobeNewswire] Press Release

IntelliCell Biosciences Stem Cells Used to Successfully Treat Bell’s Palsy and Type I Diabetes Patient
IntelliCell Biosciences, Inc. announced that it has supplied its cellular product, stromal vascular fraction cells, to Regen Medical PC for the successful treatment of a Type I diabetic patient, who had developed bilateral permanent Bell’s palsy. [Marketwire LP] Press Release

Cytori Patents Adipose-Derived Cell Therapy for Cardiovascular Disease in Australia
Cytori Therapeutics has received an Australian patent covering methods of treating cardiovascular disease using adipose-derived regenerative cells (ADRCs). The patent covers the therapeutic use of ADRCs for improving cardiac function and mechanics by preventing the deleterious histopathological and structural changes that occur in the heart following a heart attack. [Cytori Therapeutics] Press Release

InVivo Therapeutics Appoints Lou Vaickus, MD as Interim Chief Medical Officer
InVivo Therapeutics Holdings Corp. announced that Lou Vaickus, MD has been appointed as interim Chief Medical Officer. [Business Wire] Press Release
EVENTS
NEW 2013 American Society for Cell Biology Annual Meeting
December 14-18, 2013
New Orleans, United States


Visit our events page to see a complete list of events in the cell, gene and immunotherapy community.
JOB OPPORTUNITIES
NEW Postdoctoral Position – Stem Cells Research (University of Maryland Baltimore)

Assistant Professorships – Stem Cells and Regenerative Medicine (Keck School of Medicine)

Postdoctoral Research Fellow – Stem Cells (Bioprocessing Technology Institute)

Postdoctoral Research Fellow – Human Induced Pluripotent Stem Cell Research (Bioprocessing Technology Institute)

Manufacturing Manager (StemCells Inc.)

Process Development Manager (StemCells Inc.)

Manufacturing Associate (StemCells Inc.)

Research Scientist – Stem Cell Research (Approach People Recruitment)

Postdoctoral Position – Development of Cell Delivery Systems in Bone Repair (Fujifilm)

Postdoctoral Fellow – Stem Cell Research (Tsinghua University Graduate School at Shenzhen)

Postdoctoral Position – Leukemia Biology (Northwestern University)

Cellular Therapy Lab Specialist (University of Texas Medical School at Houston)

Scientist – Particle Chemistry (STEMCELL Technologies Inc.)

Research Technologist – Human Pluripotent Stem Cell Products (STEMCELL Technologies Inc.)

Research Technologist – Cell Culture Media & Matrices (STEMCELL Technologies Inc.)

Research Associate/Scientist – Antibodies Group (STEMCELL Technologies Inc.)

Research Associate – Particle Chemistry (STEMCELL Technologies Inc.)


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