Volume 13.33 | Aug 27

Issue 13.33 August 27, 2012
Cell Therapy News - Your Industry in an Instant
Your Industry in an InstantTwitter Facebook
Publications | Reviews | Science | Policy | Business | NIH | CBER | Regulatory | Events | Jobs

TOP STORY
Researchers First to Grow Lung Cells Using Stem Cell Technology
New stem cell research paved the way towards individualized medicine for patients with cystic fibrosis and other lung diseases. The study is the first to successfully use stem cells to produce mature lung cells that could potentially be used to study the disease and test drugs. [Press release from The Hospital for Sick Children discussing online prepublication in Nature Biotechnology] Press Release | Abstract

[FREE] ALDEFLUOR™ Protocol Optimization Kit – Get Yours


PUBLICATIONS (Ranked by impact factor of the journal)

Macroporous Nanowire Nanoelectronic Scaffolds for Synthetic Tissues
Three-dimensional (3D) macroporous nanoelectronic scaffolds (nanoES) mimic the structure of natural tissue scaffolds, and they were formed by self-organization of coplanar reticular networks with built-in strain and by manipulation of two-dimensional mesh matrices. NanoES exhibited robust electronic properties and have been used alone or combined with other biomaterials as biocompatible extracellular scaffolds for 3D culture of neurons, cardiomyocytes and smooth muscle cells. [Nat Mater] Abstract | Press Release

Five-Year Results of Intracoronary Infusion of the Mobilized Peripheral Blood Stem Cells by Granulocyte Colony-Stimulating Factor in Patients with Myocardial Infarction
Scientists evaluated the long-term effects of peripheral blood stem cell therapy in myocardial infarction patients. The major adverse cardiac events for five years were significantly reduced in the cell infusion group compared with the control. [Eur Heart J] Abstract

Virus-Mediated shRNA Knockdown of Nav1.3 in Rat Dorsal Root Ganglion Attenuates Nerve Injury-Induced Neuropathic Pain
To evaluate the therapeutic potential of peripheral Nav1.3 knockdown at a specific segmental level, researchers constructed an adeno-associated viral vector expressing small hairpin RNA (shRNA) against rat Nav1.3 and injected it into lumbar dorsal root ganglion of rats with spared nerve injury. [Mol Ther] Abstract | Press Release

Long-Term Follow-Up Evaluation of Results from Clinical Trial (TREAT-HGF) Using Hepatocyte Growth Factor Gene to Treat Severe Peripheral Arterial Disease
Investigators performed a phase I/IIa open-label clinical trial using intramuscular injection of naked plasmid DNA encoding hepatocyte growth factor (HGF). They reported long-term evaluation of two years after HGF gene therapy in 22 patients with severe peripheral arterial disease. [Arterioscler Thromb Vasc Biol] Abstract

Human Amniotic Fluid Stem Cell Injection Therapy for Urethral Sphincter Regeneration in an Animal Model
Researchers investigated whether periurethral injection of human amniotic fluid stem cells can restore urethral sphincter competency in a mouse model. [BMC Med] Abstract | Full Article | Press Release

Functionalized, Biodegradable Hydrogels for Control Over Sustained and Localized siRNA Delivery to Incorporated and Surrounding Cells
Researchers engineered a functionalized, biodegradable system created by covalent incorporation of cationic linear polyethyleneimine (LPEI) into photocrosslinked dextran hydrogels through a biodegradable ester linkage. The key innovation of this system is that control over the sustained release of short interference RNA (siRNA) was achieved, as LPEI could electrostatically interact with siRNA to maintain siRNA within the hydrogels and degradation of the covalent ester linkages between the LPEI and the hydrogels led to tunable release of LPEI/siRNA complexes over time. [Acta Biomater] Abstract | Press Release

Improving Dendritic Cell Vaccine Immunogenicity by Silencing PD-1 Ligands Using siRNA-Lipid Nanoparticles Combined with Antigen mRNA Electroporation
Researchers demonstrated that PD-L1 and PD-L2 siRNA delivery using DLin-KC2-DMA-containing lipid nanoparticles mediated efficient and specific knockdown of PD-L expression on human monocyte-derived dendritic cells (DC). They also demonstrated that these PD-L-silenced DC loaded with antigen mRNA superiorly boost ex vivo antigen-specific CD8+ T cell responses from transplanted cancer patients. [Cancer Immunol Immunother] Abstract | Press Release

Adipose Stem Cells Can Secrete Angiogenic Factors That Inhibit Hyaline Cartilage Regeneration
Researchers aimed to determine the effects adipose stem cell-secreted factors have in repairing chondral defects. [Stem Cell Res Ther] Abstract | Full Article | Press Release

Webinar: Brent Reynolds on Identification and Caracterization of Neural Stem Cells



SCIENCE NEWS

Neuralstem Completes Phase I ALS Stem Cell Trial
Neuralstem, Inc. announced the completion of the Phase I trial of its NSI-566 spinal cord neural stem cells for the treatment of amyotrophic lateral sclerosis (ALS), with the eighteenth patient treated. [Neuralstem, Inc.]
Press Release

Autism and Cord Blood Stem Cells: FDA Gives Green Light for Groundbreaking Clinical Trial
Sutter Neuroscience Institute and Cord Blood Registry are launching the first FDA approved clinical trial to assess the use of a child’s own cord blood stem cells to treat select patients with autism. [Cord Blood Registry] Press Release

PneumaCult™-ALI Medium for Bronchial Epithelial Cells: Watch the Video


  
NEW! REVIEWS
Based on your feedback, we’ve added a Reviews section to Cell Therapy News

Intraoperative Stem Cell Therapy
The major developments in intraoperative stem cell approaches, from in vivo models to clinical studies, are reviewed, and the potential regenerative mechanisms and the roles of different cell populations in the regeneration process are discussed. [Annu Rev Biomed Eng] Abstract

Managing Particulates in Cellular Therapy
Researchers reviewed the concept of particulates, where they originate and how they are introduced to cell therapy products, and the current methods available for their detection. The authors also reviewed the relevance of current guidance documents and present potential strategies to move forward and address and control unwanted contaminating particulates in cell therapy products. [Cytotherapy] Abstract


 
POLICY

The Maryland Stem Cell Research Commission: Public Statement
The Maryland Stem Cell Research Commission is pleased with the opinion issued by the U.S. Court of Appeals for the District of Columbia Circuit in Sherley, et al v. Sebelius, et al regarding the federal funding of human embryonic stem cell research. The position taken by the Court allows this promising stem cell research to progress in the U.S., paving the way for groundbreaking discoveries that could ameliorate a multitude of debilitating diseases and disorders. [Maryland Stem Cell Research Fund, United States] Press Release

Republican Spending Plan Casts Shadow on Science
As chairman of the House of Representatives budget committee in the current Congress, Paul Ryan has crafted a federal spending plan that contrasts sharply with that of President Barack Obama. If carried out, Ryan’s plan could cut spending on non-defense-related research and development by 5%, or $3.2 billion, below the fiscal-year 2012 budget. [American Association for the Advancement of Science, United States] Press Release

Ego v. Efficiency at the U.S. National Science Board
A new U.S. law that exempts 169 presidential appointees from having to be confirmed by the Senate has ruffled feathers at the National Science Board. The 24-member board is now part of that new category of people who can take office immediately after they say “yes” to an invitation from the White House. [National Science Board, United States] Press Release



BUSINESS

New Partnership to Drive Mass Production of Life-Saving Stem Cells – Commercialization Impact Prize Is First of Its Kind in Canada
The McEwen Centre for Regenerative Medicine-Centre for Commercialization of Regenerative Medicine Commercialization Impact Prize will solicit innovative ideas from regenerative medicine scientists working in labs throughout the McEwen Centre. The winning team(s) will be awarded up to $600,000 to pursue research that will determine how to manufacture stem cells for clinical use and drug screening. [McEwen Centre for Regenerative Medicine] Press Release

Silence Therapeutics Signs Collaboration with MiReven Pty Ltd to Evaluate Delivery of Novel MicroRNA-Based Therapeutics
Silence Therapeutics plc announced that it has signed an agreement with MiReven Pty Ltd to assess the delivery potential of Silence’s proprietary delivery systems with MiReven’s novel microRNA-based therapeutics. [Silence Therapeutics plc] Press Release

Pluristem and World Renowned Charité Berlin-Brandenburg Center for Regenerative Therapies Renew Five-Year Collaborative Research Agreement
Pluristem Therapeutics, Inc. announced it has renewed a five-year Collaborative Research Agreement with the Berlin-Brandenburg Center for Regenerative Therapy at Charite – University Medicine Berlin. [Pluristem Therapeutics, Inc.] Press Release

ThermoGenesis Announces AXP® Product Purchase and Distribution Agreement with Golden Meditech Holdings Limited
ThermoGenesis Corp. announced that it has signed a wide ranging product purchase and distribution agreement for its AXP® AutoXpress® (AXP) System used for the processing of stem cells from cord blood with Golden Meditech Holdings Limited. [ThermoGenesis Corp.] Press Release

Team Awarded Nearly $1.5 Million to Develop New Approaches to Treat Cancer
Scientists from The Scripps Research Institute have been awarded approximately $1.5 million from the National Institutes of Health to identify and develop new therapeutic approaches against a broad spectrum of cancers. [The Scripps Research Institute] Press Release

Pluristem Commences U.S. FDA Phase II Clinical Trial for Intermittent Claudication: Duke University Medical Center Is First of Five Sites Already Approved
Pluristem Therapeutics, Inc. announced it will initiate Phase II clinical trials in the United States to evaluate the safety and efficacy of its PLacental Expanded cells in the treatment of intermittent claudication. [Pluristem Therapeutics, Inc.] Press Release

IntelliCell BioSciences Files Patent Application for a New Mechanical Method to Separate Stromal Vascular Fraction from the Blood Vessels in Adipose Tissue
IntelliCell BioSciences, Inc. announced that it has filed a patent application for a new mechanical method to separate stromal vascular fraction from the blood vessels in adipose tissue to be used clinically in regenerative medicine. [PR Newswire Association LLC] Press Release

Successful Growth of BioDiem’s Virus in VIVALIS EB66® Cell Line
BioDiem Ltd announced successful results from two programs of work carried out by French partner VIVALIS, confirming the ability of BioDiem’s Live Attenuated Influenza Virus to grow in VIVALIS’ proprietary EB66® cell line. VIVALIS offers research and commercial licenses for its EB66® cell line, derived from duck embryonic stem cells, to pharmaceutical and biotechnology companies for the production of therapeutic and prophylactic viral vaccines, virosomes, VLP’s, and recombinant proteins. [VIVALIS] Press Release

Anne-Marie Duliege Appointed to Governing Board of California’s Stem Cell Agency
Anne-Marie Duliege, MD, Chief Medical Officer of Affymax Inc., has been appointed to the Independent Citizens Oversight Committee, the governing board of California’s stem cell agency, the California Institute for Regenerative Medicine. [California Institute for Regenerative Medicine] Press Release



NIH

NIH’s Millionaires to Get Extra Scrutiny
The National Institutes of Health (NIH) plans to give extra scrutiny to proposals from researchers receiving more than $1 million a year in direct support from grants-and may not fund them if the research overlaps with what they’re already doing. Press Release

National Institute of Arthritis and Musculoskeletal and Skin Diseases; Notice of Closed Meeting (FR Doc No: 2012-20816)

National Institute of Biomedical Imaging and Bioengineering; Notice of Closed Meeting (FR Doc No: 2012-20804)

National Institute of Biomedical Imaging and Bioengineering; Notice of Closed Meeting (FR Doc No: 2012-20557)

Office of the Director, National Institutes of Health; Notice of Meeting (FR Doc No: 2012-20556)

Center for Scientific Review; Notice of Closed Meetings (FR Doc No: 2012-20606)

National Center for Advancing Translational Sciences; Notice of Meetings (FR Doc No: 2012-20273)



CBER
September 19, 2012: Vaccines and Related Biological Products Advisory Committee Meeting: Waivers for Conflicts of Interest


REGULATORY

Food and Drug Administration (United States)

Science Board to the Food and Drug Administration; Notice of Meeting (FR Doc No: 2012-20782)

Agreements and Memoranda of Understanding Between the Food and Drug Administration and Other Departments, Agencies, and Organizations (FR Doc No: 2012-20610)

Agency Information Collection Activities; Proposed Collection; Comment Request; Bar Code Label Requirement for Human Drug and Biological Products (FR Doc No: 2012-20205)


Therapeutic Goods Administration (Australia)

Documents Released Under Section 11C of the Freedom of Information Act 1982



EVENTS

NEW The Jackson Laboratory: Humanized NSG Mice – An Innovative Platform for Advancing Preclinical Research
August 30, 1:00PM (ET in US)
Webinar

NEW 2nd World Congress on Cell Science & Stem Cell Research
November 12-14, 2012
San Antonio, United States

Visit our events page to see a complete list of events in the cell, gene and immunotherapy community.



JOB OPPORTUNITIES

Scientist – Mesenchymal Cell Research (STEMCELL Technologies, Inc.)

Scientific Communications & Publishing Coordinator (STEMCELL Technologies, Inc.)

Quality Control Operations Coordinator (STEMCELL Technologies, Inc.)

Research Technologist – Research and Development (STEMCELL Technologies, Inc.)

Research Technologist – Media Development (STEMCELL Technologies, Inc.)

Postdoctoral Research Position (University Lille 2 France)

Postdoctoral Position – Induced Pluripotent Stem Cell Research (University of Washington)

Chief Scientific and Medical Officer (Living Cell Technologies)

Postdoctoral Fellowship (Vaccine & Gene Therapy Institute, Florida)

Postdoctoral Fellow – Preclinical Group (BN ImmunoTherapeutics)

Postdoctoral Positions – Immunity and Inflammation (CNRS & University of Toulouse, France)


Recruit Top Talent:
Reach more than 55,000 potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.