Volume 11.35 | Sep 13

Cell Therapy News 11.35, September 13, 2010.
In this issue:  Science  |  Policy  |  Business  |  NIH  |  CBER  |  Regulatory  |  Events Subscribe  |  Unsubscribe

TOP STORY  


Researchers Illuminate Operation of Molecular Gateway to the Cell Nucleus
Biophysicists have traced with unprecedented resolution the paths of cargos moving through the nuclear pore complex, a selective nanoscale aperture that controls access to the cell’s nucleus, and answered several key questions about its function. [Press release from the California Institute for Quantitative Biosciences discussing online prepublication in Nature]

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Complimentary Webinar Presented by STEMCELL Technologies: EPO and Erythropoiesis, Detecting Lineage Commitment



SCIENCE NEWS


Researchers Uncover New Ovarian Cancer Gene (A Connection Between Cancer and Endometriosis)
Researchers reveal a major new cancer gene – ARID1A. Mutations are frequent in this gene and link two types of ovarian cancer to endometriosis. [Press release from the British Columbia Cancer Agency discussing online prepublication in the New England Journal of Medicine]

Twins Help Researchers to Find Genes for Blindness
Using data collected from over 1,000 sets of twins, research has uncovered genes that affect eyesight as part of several conditions. Researchers discovered a new gene for myopia and new genes affecting glaucoma risk. [Press release from the Queensland Institute of Medical Research discussing online prepublication in Nature Genetics]

Lung Cancer Culprit Could Offer Target for Therapy
A tiny molecule that spurs the progression of non-small-cell lung cancer could become a player in fighting the disease, say researchers. [Press release from the University of Texas Southwestern Medical Center discussing online prepublication in Cancer Cell]

Biologists Find Way to Reduce Stem Cell Loss During Cancer Treatment
Biologists have discovered that a gene critical for programmed cell death is also important in the loss of adult stem cells, a finding that could help to improve the health and well-being of patients undergoing cancer treatment. [Press release from the University of California, San Diego discussing online prepublication in Nature Cell Biology]

How Physical Environment Influences Stem Cell Development
Recent research has revealed how physical qualities — and not only chemical ones — may have an influence in determining how adult stem cells from the bone marrow develop into differentiated ones. [Press release from ScienceDaily discussing online prepublication in Nature Physics]

Scientist Identifies New Gene for Memory
A scientist has for the first time identified a new gene that is required for memory formation in Drosophila. [Press release from the Scripps Research Institute discussing online prepublication in Neuron]

With HMGB1's Help, Cells Dine In
A team led by researchers at the University of Pittsburgh Cancer Institute discovered a link between autophagy and the protein HMGB1. [Press release from EurekAlert! discussing online prepublication in the Journal of Cell Biology]

Scientists Create New Process to “Program” Cancer Cell Death
Researchers have engineered a fundamentally new approach to killing cancer cells. The process uses small RNA molecules that can be programmed to attack only specific cancer cells; then, by changing shape, those molecules cause the cancer cells to self-destruct. [Press release from the California Institute of Technology discussing online prepublication in the Proceedings of the National Academy of Sciences USA]

Cloud Computing Method Greatly Increases Gene Analysis
Researchers have developed new software that greatly improves the speed at which scientists can analyze RNA sequencing data. [Press release from the Johns Hopkins Bloomberg School of Public Health discussing online prepublication in Genome Biology]

Regenerative Cellular Therapy in Chronic Kidney Disease Extends Survival
Rodents with chronic kidney disease were treated with healthy kidney cells to catalyze the regeneration of functional kidney tissue and delay disease progression, as evidenced by extended survival, improved kidney filtration, and reduced severity of kidney tissue pathology. [Press release from Tengion, Inc. discussing online prepublication in the American Journal of Physiology Renal Physiology]

Third Generation Map of Human Genetic Variation Published
An international consortium today published a third-generation map of human genetic variation, called the HapMap, which includes data from an additional seven global populations, increasing the total number to 11 populations. [National Institutes of Health Press Release]

UCSF Unveils Model for Implantable Artificial Kidney to Replace Dialysis
Researchers unveiled a prototype model of the first implantable artificial kidney, in a development that one day could eliminate the need for dialysis. [University of California, San Francisco Press Release]

CURRENT PUBLICATIONS (Ranked by Impact Factor of the Journal)

ARID1A Mutations in Endometriosis-Associated Ovarian Carcinomas
Data implicate ARID1A as a tumor-suppressor gene frequently disrupted in ovarian clear-cell and endometrioid carcinomas. Since ARID1A mutation and loss of BAF250a can be seen in the preneoplastic lesions, researchers speculate that this is an early event in the transformation of endometriosis into cancer. [N Engl J Med]

Selectivity Mechanism of the Nuclear Pore Complex Characterized by Single Cargo Tracking
Researchers show that import proceeds by successive substeps comprising cargo capture, filtering and translocation, and release into the nucleus. [Nature]

A Genome-Wide Association Study Identifies a Susceptibility Locus for Refractive Errors and Myopia at 15q14
Data suggest that common variants at 15q14 influence susceptibility for refractive errors in the general population. [Nat Genet]

Common Variants Near CAV1 and CAV2 are Associated with Primary Open-Angle Glaucoma
The risk variant identified here is located close to CAV1 and CAV2, both of which are expressed in the trabecular meshwork and retinal ganglion cells that are involved in the pathogenesis of primary open-angle glaucoma. [Nat Genet]

Modulation of K-Ras-Dependent Lung Tumorigenesis by MicroRNA-21
Researchers show that overexpression of MicroRNA-21 (miR-21) enhances tumorigenesis and that genetic deletion of miR-21 partially protects against tumor formation. [Cancer Cell]

Puma Is Required for p53-Induced Depletion of Adult Stem Cells
Findings suggest a key role of p53-dependent apoptosis in depleting adult stem cells after the accumulation of DNA damage, which leads to a decrease in tissue regeneration. [Nat Cell Biol]

Optimal Matrix Rigidity for Stress-Fiber Polarization in Stem Cells
Researchers present a theoretical model and experiments demonstrating that the alignment of stress fibers within stem cells is a non-monotonic function of matrix rigidity. [Nat Phys]

Gilgamesh Is Required for rutabaga-Independent Olfactory Learning in Drosophila
Researchers identified alleles of the gilgamesh (gish) gene, which encodes a casein kinase I(gamma) homolog that is preferentially expressed in the mushroom body neurons. [Neuron]

Endogenous HMGB1 Regulates Autophagy
Endogenous HMGB1 is a critical pro-autophagic protein that enhances cell survival and limits programmed apoptotic cell death. [J Cell Biol]

Selective Cell Death Mediated by Small Conditional RNAs
Results indicate that programmable mechanical transduction with small conditional RNAs represents a fundamental principle for exploring therapeutic conditional regulation in living cells. [Proc Natl Acad Sci U S A]

Role of Symmetric and Asymmetric Division of Stem Cells in Developing Drug Resistance
Researchers derived a previously undescribed estimate of the probability of developing drug resistance by the time a tumor is detected and calculate the expected number of resistant cancer stem cells at the time of tumor detection. [Proc Natl Acad Sci U S A]

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POLICY


Appeals Court Stays Stem Cell Injunction
A federal appeals court stayed, or suspended, a preliminary injunction issued two weeks ago that brought federal funding for human embryonic stem cell research to a standstill. [Court of Appeals, United States]

New Animal-Research Regulations for the European Union
European scientists will use fewer animals in research when newly approved regulations come into effect across the European Union. [European Parliament, European Union]

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BUSINESS


STEMSOFT® Software Inc. Licenses StemLab® Software to Arizona’s Celebration Stem Cell Centre
STEMSOFT Software Inc., the leading provider of software solutions for the cell therapy and transplant community, is pleased to announce the licensing of StemLab, the leading cell therapy and cord blood banking laboratory software, to the Celebration Stem Cell Centre in Gilbert, Arizona. [STEMSOFT Software Inc. Press Release]

Jennerex and Transgene Enter into an Exclusive Partnership for the Development and Commercialization of JX-594 for the Treatment of Cancers
Jennerex, Inc. and Transgene announced that they have entered into an exclusive partnership to develop and commercialize JX-594 for the treatment of solid tumors in Europe, the Commonwealth of Independent States and the Middle East. [Jennerex Inc. Press Release]

Bristol-Myers Squibb to Acquire ZymoGenetics
Bristol-Myers Squibb Company and ZymoGenetics, Inc. announced that the companies have signed a definitive agreement providing for the acquisition of ZymoGenetics by Bristol-Myers Squibb, for $9.75 per share in cash. [Bristol-Myers Squibb Press Release]

Geron Obtains Exclusive License for Deriving Cartilage from Human Embryonic Stem Cells from University of Edinburgh
Geron Corporation announced that it has entered into a worldwide, exclusive license agreement with the University of Edinburgh covering technology that allows the efficient production of chondrocytes from human pluripotent stem cells. [Geron Corporation Press Release]

AstraZeneca and UCL Join Forces in Sight-Related Stem Cell Medicine
AstraZeneca and University College London (UCL) have entered into a collaboration to develop regenerative medicines for diabetic retinopathy. [University College London Press Release]

RTI Biologics and Athersys Announce Collaboration in the Orthopedic Market
RTI Biologics Inc. (RTI) and Athersys Inc. announced an agreement under which Athersys will provide RTI access to its Multipotent Adult Progenitor Cell technologies. [Athersys Inc. Press Release]

Anchor Therapeutics Enters Into Collaborative Research, Option and License Agreement for its Pepducin Technology
Anchor Therapeutics announced that it has entered into a collaboration and license agreement with Ortho-McNeil-Janssen Pharmaceuticals, Inc. with the goal of developing G protein coupled receptor-targeted therapeutic compounds utilizing Anchor's proprietary pepducin technology. [Anchor Therapeutics Press Release]

Forbion Capital Partners Raises EUR190 Million for New Investments
Forbion Capital Partners, a leading investment firm dedicated to the life science sector, announced the final closings of both FCF I Co-Invest Fund and of FCF II, raising a total of more than EUR190 million ($240 million). [Forbion Capital Partners Press Release]

Cellerant Therapeutics Awarded $153 Million Contract by Biomedical Advanced Research and Development Authority to Develop Treatment for Acute Radiation Syndrome
Cellerant Therapeutics Inc. announced that it has signed a contract valued at up to $153 million over five years with the Biomedical Advanced Research and Development Authority in the Office of the Assistant Secretary for Preparedness and Response of the Department of Health and Human Services, to develop CLT-008, a cellular therapy for the treatment of Acute Radiation Syndrome. [Cellerant Therapeutics Inc. Press Release]

Lilly to Invest Up to $150 Million in Venture Capital
Eli Lilly & Co., facing competition from cheaper copies of its top-selling drug next year, plans to invest as much as $150 million in three venture capital funds to aid development of new medicines. [Bloomberg]
 
iPierian Announces Second Close of $28 Million Series B Financing
Pierian, Inc. announced the second closing of its Series B equity financing, bringing the total amount raised in this round to $28 million. [iPierian Press Release]

Tekmira Pharmaceuticals Receives Clearance from FDA to Initiate TKM-PLK1 Phase I Clinical Trial
Tekmira Pharmaceuticals Corporation announced that its Investigational New Drug application for TKM-PLK1 has been cleared by the United States Food and Drug Administration (FDA) allowing Tekmira to initiate a Phase I human clinical trial. [Tekmira Pharmaceuticals Corporation Press Release]

Kansas State Receives Patent for Noncontroversial Source of Stem Cells
Kansas State University has been issued a patent for a plentiful and noncontroversial source of stem cells from a substance in the umbilical cord. [Kansas State University Press Release]

Silence Therapeutics Issued New Patents Covering siRNA Sequences for RNA Interference Therapeutics
Silence Therapeutics plc announced the issuance of two new patents by the United States Patent and Trademark Office which are broadly directed to double-stranded short interfering RNA sequences against the validated cancer targets epidermal growth factor receptor related protein and vascular endothelial growth factor receptor 1. [Silence Therapeutics plc Press Release]

Genzyme Announces Agreement to Sell Genetic Testing Business to LabCorp
Genzyme Corporation announced that it has entered into an asset purchase agreement under which Laboratory Corporation of America Holdings will acquire Genzyme Genetics for $925 million in cash. [Genzyme Corporation Press Release]

Genetix Pharmaceuticals Renamed bluebird bio; Announces Appointment of Nick Leschly as Chief Executive Officer
bluebird bio announced that it has changed the company name from Genetix Pharmaceuticals, Inc., to bluebird bio, Inc., effective immediately. [bluebird bio Press Release]


NIH
 

NIH Rushes to Hand Out Stem Cell Grants During Temporary Stay
The National Institutes of Health (NIH) is scrambling to push out research grants for work on human embryonic stem cells (hESCs) and has given a cautious all-clear to in-house stem cell researchers after an appeals court yesterday temporarily lifted a ban on federal funding for hESC research.

NIH Expands Network Focused on How Genes Affect Drug Responses
The National Institutes of Health plans to spend $161.3 million over the next five years to expand the Pharmacogenomics Research Network, a nationwide collaborative of scientists focused on understanding how genes affect a person’s response to medicines.

Funds Awarded for Disease Demonstration Studies and Technology Development
The National Institutes of Health announced it has awarded approximately $42 million to expand the scope of eight demonstration projects designed to link changes in the human microbiome to health and disease.
 
NIH Statement Regarding Stay of Stem Cell Injunction

National Institute of Biomedical Imaging and Bioengineering; Notice of Closed Meeting (FR Doc. 2010-22327)

National Heart, Lung, and Blood Institute; Notice of Closed Meeting (FR Doc. 2010-22314)

National Center for Research Resources; Notice of Closed Meetings (FR Doc. 2010-22529) 

National Institute of Mental Health Announces Availability of Funds for Competitive Revision Applications for a Repository Supporting Stem Cell Research Relevant to Mental Disorders (U24) (NOT-MH-10-032)

Notice of Correction:  Application Due Date for RFA-HG-10-012, Revolutionary Genome Sequencing Technologies – The $1000 Genome (R01) and RFA-HG-10-013, Revolutionary Genome Sequencing Technologies – The $1000 Genome (R21) (Notice Number:NOT-HG-10-021)
 
Knockout Mouse Production and Cryopreservation (U42) (RFA-RM-10-013)
 
Knockout Mouse Phenotyping Project Database (U54) (RFA-RM-10-012)
 
Knockout Mouse Phenotyping (U54) (RFA-RM-10-011)
 
Dynamics of Host-Associated Microbial Communities (R01) (RFA-GM-12-001)
 
Enhancing Peer Review:  Reminder of and Correction to Previous Notice on A2 Resubmission Opportunities for Eligible Applications (NOT-OD-10-135)
 
Notice of Correction to RFA-AG-11-010, Basic Research on Self-Regulation (R21) (NOT-AG-10-011)

Banner


CBER


Agenda for the Public Workshop on Cell and Gene Therapy Clinical Trials in Pediatric Populations

Public Meeting on Animal Models–Essential Elements to Address Efficacy Under the Animal Rule; and Reopening of Comment Period [Docket No. FDA-2009-D-0007]
 
Center for Biologics Evaluation and Research eSubmitter Pilot Evaluation Program for Blood Establishments That Collect Whole Blood and Blood Components [Docket No. FDA-2010-N-0436] 

Complete List of Licensed Products and Establishments

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REGULATORY


FOOD AND DRUG ADMINISTRATION (United States)

Cell and Gene Therapy Clinical Trials in Pediatric Populations; Public Workshop [Docket No. FDA-2010-N-0001]

MEDICINES AND HEALTHCARE PRODUCTS REGULATORY AGENCY (United Kingdom)

Variations Legislation 2010 – Details of Our Experience to Date, Submissions Audit and Update to FAQs

Information Sent to Healthcare Professionals in August About the Safety of Medicines



EVENTS (Listed by Date)

Select Biosciences 7th Annual RNAi & miRNA Europe
September 14-15, 2010
Dublin, Ireland

Select Biosciences Inaugural Epigenetics Europe Conference
September 14-15, 2010
Dublin, Ireland

Select Biosciences Inaugural Genomics Automation Europe Conference
September 14-15, 2010
Dublin, Ireland

Tissue Engineering & Regenerative Medicine International Society (TERMIS) – Asia Pacific 2010
September 15-17, 2010
Sydney, Australia

First Annual BIO India International Partnering Conference
September 21-22, 2010
Hyderabad, India

NEW Third Annual Maryland Stem Cell Research Symposium
September 22, 2010
Gaithersburg, United States

Cellular Therapy of Cancer Symposium – ATTACK Project Meeting
September 24-27, 2010
Montpellier, France

International Society for Cellular Therapy 2nd Annual Symposium on Stem Cell Translation: Best Practices & Regulatory Considerations
September 27-28, 2010
San Francisco, United States

International Society for Cell and Gene Therapy of Cancer (ISCGT) Congress
September 27-29, 2010
Doha, Qatar

4th American Association of Cancer Research International Conference on Molecular Diagnostics in Cancer Therapeutic Development
September 27-30, 2010
Denver, United States

Select Biosciences 6th Annual Ion Channel Targets Conference
September 28-29, 2010
Washington, DC, United States

Cytokines 2010: Cytokines in Infectious Diseases, Autoimmune Disorders and Cancer
October 3-7, 2010
Chicago, United States

2010 World Stem Cell Summit
October 4-6, 2010
Detroit, United States

9th Annual BIO Investor Forum
October 5-6, 2010
San Francisco, United States

5th World Congress on Preventive & Regenerative Medicine (WCRM)
October 5-7, 2010
Hannover, Germany

17th Annual Meeting German Society for Gene Therapy (DG-GT e.V.)
October 6-9, 2010
Munich, Germany

COGEM Symposium: GM Viruses as Medicine: Panacea or Pandora's Box?
October 7, 2010
Amsterdam, The Netherlands

American Association of Blood Banks (AABB) Annual Meeting & Cellular Therapy and Transfusion Medicine Expo (CTTXPO) 2010
October 9-12, 2010
Baltimore, United States

18th Annual BioPartnering Europe
October 10-12, 2010
London, United Kingdom

3rd Biobridge “Generation Regeneration” Conference
October 11, 2010
Geneva, Switzerland

New York Stem Cell Foundation Fifth Annual Translational Stem Cell Research Meeting
October 12-13, 2010
New York, United States

Translational Cancer Research for Basic Scientists
October 17-22, 2010
Boston, United States

2010 NanoMedicine Summit
October 18-19, 2010
Cleveland, United States

BIO Intellectual Property Counsels Committee Fall Conference and Committee Meeting
October 18-20, 2010
Boston, United States

6th Modern Drug Discovery & Development Summit (M3D)
October 20-22, 2010
San Francisco, United States

European Society of Gene and Cell Therapy (ESGCT) 18th Annual Congress
October 22-25, 2010
Milan, Italy

3rd Annual Dubai Congress on Anti-Aging and Aesthetic Medicine (DCAAAM)
October 26-27, 2010
Dubai, United Arab Emirates

World Stem Cells & Regenerative Medicine Congress Asia 2010
October 26-29, 2010
Singapore City, Singapore

Select Biosciences 3rd Annual Molecular Diagnostics World Congress
October 28-29, 2010
San Diego, United States

Fraunhofer Life Science Symposium 2010
October 29-30, 2010
Leipzig, Germany

Stem Cell Society Singapore Symposium 2010: Translating Science to Therapy
November 2-3, 2010
Singapore City, Singapore

BioMalaysia 2010 Conference and Exhibition
November 2-4, 2010
Kuala Lumpur, Malaysia


World Cord Blood Congress
November 4-7, 2010
Marseille, France

Select Biosciences 5th Annual European Biomarkers Summit
November 9-10, 2010
Florence, Italy

Select Biosciences International Forum on Stem Cells
November 12-13, 2010
Tianjin, China

Select Biosciences 2nd Annual RNAi Asia Conference
November 15-16, 2010
Singapore City, Singapore

BIO-Europe International Partnering Conference
November 15-17, 2010
Munich, Germany

9th Annual Gene Therapy Symposium for Heart, Lung, and Blood Diseases
November 17-19, 2010
Sonoma, United States

8th Annual Commercial Translation of Regenerative Medicine Conference
November 18-19, 2010
London, United Kingdom

Stem Cell Network 10th Annual Scientific Meeting
November 22-24, 2010
Calgary, Canada

HealthTech and Medicines Knowledge Transfer Network 7th Annual BioProcessUK Conference
November 24-25, 2010
Manchester, United Kingdom

2nd European Association for Cardio-Thoracic Surgery (EACTS) Meeting on Cardiac and Pulmonary Regeneration
December 2-3, 2010
Vienna, Austria

Tissue Engineering & Regenerative Medicine International Society (TERMIS) – North America 2010 Annual Conference
December 5-8, 2010
Orlando, United States

Select Biosciences 5th Annual Stem Cells World Congress
January 24-25, 2011
San Diego, United States

BIO Asia International Partnering Conference
January 24-25, 2011
Tokyo, Japan

Phacilitate 7th Annual Cell & Gene Therapy Forum 2011
January 24-26, 2011
Washington DC, United States

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.


 

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