Volume 11.15 | Apr 26

Cell Therapy News 11.15, April 26, 2010.
In this issue:  Science  |  Policy  |  Business  |  NIH  |  CBER  |  Regulatory  |  Events Unsubscribe


TOP STORY

Gene Silencing may be Responsible for Induced Pluripotent Stem Cells' Limitations
In a recent study, investigators describe finding that an important cluster of genes is inactivated in induced pluripotent stem cells that do not have the full development potential of embryonic stem cells. [Press release from EurekAlert! discussing online prepublication in Nature]

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SCIENCE NEWS

Tohoku University Team Discovers New Type of Stem Cells in Human Skin, Bone
A research team from Tohoku University has discovered a new type of pluripotent stem cell in the skin and bone marrow of adults, providing a possible third source of stem cells after embryonic stem cells and human-made induced pluripotent stem cells. [Press release from The Mainichi Daily News discussing online prepublication in Proceedings of the National Academy of Sciences USA]

An RNA Clue to Breast Cancer's Spread Clue
Researchers may have found a new chink in the armor of breast cancer: a short stretch of RNA that can curb the growth of metastasized breast tumors in mice long after the cancers start growing. [Science Press Release]

Scientist Grows Jaw Bone From Adult Stem Cells
A Columbia scientist has become the first to grow a complex, full-size bone from human adult stem cells. [Press release from Columbia University discussing online prepublication in Proceedings of the National Academy of Sciences USA]

Singapore Scientists’ Finding on Early Embryonic Development has Direct Impact on Regenerative Medicine and Assisted Reproduction
Scientists have recently generated significant single cell expression data crucial for a detailed molecular understanding of mammalian development from fertilization to embryo implantation, a process known as the preimplantation period. [Press release from the Genome Institute of Singapore discussing online prepublication in Developmental Cell]

Researchers Modify Virus to Hunt Down and Wipe Out Cancer Cells
Researchers exploited the unique markers that appear on the surface of cancer cells to engineer a range of proteins that recognize and attach to these markers. These 'targeting' proteins can be added to a virus so that it recognizes and infiltrates cancer cells. [Press release from University of Leeds discussing online prepublication in Gene Therapy]

Scientists Create Stem Cells from Eggs of Aging Mice
Researchers have created stem cells from the eggs of aging mice that could be used for reproductive purposes and regenerative medicine. [Press release from New York University Langone Medical Center discussing online prepublication in Aging Cell]

Body Builders – The Worms that Point the Way to Understanding Tissue Regeneration
Scientists have discovered the gene that enables an extraordinary worm to regenerate its own body parts after amputation — including a whole head and brain. [Press release from The University of Nottingham discussing online prepublication in PLoS Genetics]

Advanced Cell Technology’s Studies to Support Phase I Multicenter Trial of Patients with Stargardt’s Macular Dystrophy Demonstrate Excellent Safety Profile
Advanced Cell Technology, Inc. announced that it has completed key animal studies in connection with its Phase I multicenter study using embryonic stem cell derived Retinal Pigment Epithelium cells to treat patients with Stargardt’s Macular Dystrophy, for which it filed an Investigational New Drug Application with the U.S. Food and Drug Administration in November. [Advanced Cell Technology, Inc. Press Release]

StemCells, Inc. Plans to Advance to Second Clinical Trial in Batten Disease
StemCells, Inc. announced that it has submitted a protocol to the Food and Drug Administration for initiation of a second clinical trial of its proprietary HuCNS-SC® human neural stem cells in neuronal ceroid lipofuscinosis, which is also often referred to as Batten disease. [StemCells, Inc. Press Release]

The Food and Drug Administration Approves Stemedica Investigational New Drug Application for Ischemic Stroke Clinical Trial
Stemedica Cell Technologies, Inc. announced that the U.S. Food and Drug Administration approved its application for an Investigational New Drug for a clinical trial for ischemic stroke using Stemedica's high potency proprietary allogeneic stem cells. [Stemedica Cell Technologies, Inc. Press Release]

CURRENT PUBLICATIONSAberrant Silencing of Imprinted Genes on Chromosome 12qF1 in Mouse Induced Pluripotent Stem Cells
By comparing genetically identical mouse embryonic stem cells and induced pluripotent stem cells (iPSCs), researchers show here that their overall messenger RNA and microRNA expression patterns are indistinguishable with the exception of a few transcripts encoded within the imprinted Dlk1–Dio3 gene cluster on chromosome 12qF1, which were aberrantly silenced in most of the iPSC clones. [Nature]

Resolution of Cell Fate Decisions Revealed by Single-Cell Gene Expression Analysis from Zygote to Blastocyst
Results illustrate the power of single-cell expression analysis to provide insight into developmental mechanisms. The technique should be widely applicable to other biological systems. [Dev Cell]

Generation of Pluripotent Stem Cells from Eggs of Aging Mice
These data demonstrate that eggs from old mice can generate pluripotent stem cells, and suggest that the isolation and in vitro culture of embryonic stem cells must select cells with high levels of DNA and telomere integrity, and/or with capacity to repair DNA and telomeres. [Aging Cell]

Retargeted Adenoviral Cancer Gene Therapy for Tumor Cells Overexpressing Epidermal Growth Factor Receptor or Urokinase-Type Plasminogen Activator Receptor
Investigators assessed the ability of bispecific fusion proteins to improve adenovirus-mediated transfer of therapeutic and marker transgenes. [Gene Ther]

Knockdown of SOD1 Sensitizes the CD34+ CML Cells to Imatinib Therapy
In this study, researchers found that the CD34+ subpopulation in the chronic myelogenous leukemia (CML) cell line K562 had a higher expression of SOD1 than that in the CD34 negative cells. [Med Oncol]

Long Term Expansion of Undifferentiated Human Induced Pluripotent Stem and Embryonic Stem Cells in Suspension Culture Using a Defined Medium
Researchers have applied human induced pluripotent stem cells (hiPS) expressing eGFP under control of the OCT4 promoter to establish the expansion of undifferentiated human embryonic stem and hiPS cells in suspension culture. [Stem Cell Res

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POLICY

Michigan Senate Passes Stem Cell Regulation Package
The Republican-led Senate passed a package of regulations critics say will place a chill on stem cell research in violation of the Michigan Constitution. [Michigan Senate, United States]

Gubernatorial Candidates Talk Ways to Boost Bioscience
Five gubernatorial candidates offered their prescriptions for creating a healthier climate for Minnesota's biotech industry that included lower taxes, higher government spending, and faith in science over ideology. [Minnesota, United States] 

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BUSINESS

A Skeptic Questions Cancer Genome Projects
Fueled by hundreds of millions of grant dollars, biomedical researchers have begun sequencing the genomes of thousands of tumor samples in the past few years, linking up scores of labs and sequencing centers in a massive effort to identify the genes behind major cancers. But a leading cancer geneticist questioned whether this strategy still makes sense. [Science Insider]

Vatican Supports Stem Cell Initiative Led By University of Maryland School of Medicine
Researchers at the University of Maryland School of Medicine are leading a new international research initiative, funded in part by the Vatican, to explore the therapeutic potential of intestinal stem cells. [University of Maryland School of Medicine Press Release]

Silence Therapeutics and AstraZeneca Extend siRNA Delivery Collaboration
Silence Therapeutics plc announces that the Company and AstraZeneca have agreed to a one-year extension of their ongoing small interfering RNA delivery collaboration. [Silence Therapeutics plc Press Release]

Ontario's $11.5 Million will Build Network for Stem Cell-Based Therapies
McMaster University's Stem Cell and Cancer Research Institute has received $11.5 million to lead a world-class initiative to develop new stem cell-based therapies. [McMaster University Press Release]

NeoStem, Inc. and ImmuneRegen BioSciences® Announce a Collaborative Agreement to Advance Stem Cell Technology
NeoStem, Inc. and ImmuneRegen Biosciences, Inc. announced that they have entered into a Collaborative Research Agreement, focused on the development of an advanced, adult human stem cell product. [PR Newswire]

Florida Biotech Research Money in Jeopardy
Florida researchers could lose $50 million in biomedical research funding due to the state’s $3 billion budget deficit. [Orlando Business Journal]

Biotech Gets Lease Agreement Go-Ahead from Rochester Council
The Rochester City Council approved a lease agreement at its regular meeting allowing the company to open a manufacturing facility on the third floor of the city's Minnesota Bioscience Center. [Post-Bulletin]

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NIH

Instructions for Completion and Technical Evaluation of the Vertebrate Animal Section (VAS) in NIH Contract Proposals (NOT-OD-10-049)

Request for Information (RFI): Priorities for the NIH Adherence Research Network (NOT-OD-10-078)



CBER

Waivers for Conflicts of Interest for the May 7, 2010 Vaccines and Related Biological Products Advisory Committee Meeting



REGULATORY

FOOD AND DRUG ADMINISTRATION (United States)

FDA Announces Draft Revised Guidance on Transparency and Advisory Committees

Risk Communication Advisory Committee; Notice of Meeting [Docket No. FDA-2010-N-0001]

Draft Guidance for the Public, Food and Drug Administration Advisory Committee Members, and Food and Drug Administration Staff: Public Availability of Advisory Committee Members' Financial Interest Information and Waivers; Availability [Docket No. FDA-2002-D-0094]



EVENTS

5th Canadian Symposium on Gene Therapy and Vaccines
May 2-4, 2010
Grenville-sur-la-Rouge, Canada

Society for Biological Engineering's (SBE) 2nd International Conference on Stem Cell Engineering
May 2-5, 2010
Boston, United States

Select BioSciences 4th Annual RNAi & miRNA World Congress
May 5-7, 2010
Boston, United States

World Stem Cells & Regenerative Medicine Congress 2010
May 11-13, 2010
London, United Kingdom

American Society of Gene & Cell Therapy (ASGCT) 2010 Clinical Trials Training Course and 13th Annual Meeting
May 17-22, 2010
Washington, DC, United States

2010 Mater Medical Research Institute (MMRI) Stem Cell Symposium: Epigenetics, Transcriptomics and Nanobiotechnology of Stem Cells
May 20-21, 2010
Brisbane, Australia

16th Annual International Society for Cellular Therapy (ISCT) Meeting
May 23-26, 2010
Philadelphia, United States

ESTOOLS International Scientific Symposium: Stem Cells in Biology and Disease
May 26-28, 2010
Lisbon, Portugal

Tissue Engineering & Regenerative Medicine International Society (TERMIS) – European Union 2010
June 13-17, 2010
Galway, Ireland

International Society for Stem Cell Research (ISSCR) 8th Annual Meeting
June 16-19, 2010
San Francisco, United States

XXXIst International Congress of the International Society of Blood Transfusion (ISBT) in joint cooperation with the 43rd Congress of the German Society for Transfusion Medicine and Immunohematology (DGTI)
June 26-July 1, 2010
Berlin, Germany

United Kingdom National Stem Cell Network (UKNSCN) 3rd Annual Scientific Conference
July 12-14, 2010
Nottingham, United Kingdom

2nd International Conference on Cellular and Molecular Bioengineering (ICCMB2)
August 2-4, 2010
Singapore City, Singapore

Select BioSciences 3rd Annual Stem Cells Europe Conference
August 24-25, 2010
Edinburgh, Scotland

International Society for Cellular Therapy (ISCT) – Europe 2nd Regional Meeting
September 11-14, 2010
Belgirate, Italy

Hydra VI: The European Summer School on Stem Cells & Regenerative Medicine
September 11-17, 2010
Hydra, Greece

Stem Cells USA & Regenerative Medicine Congress 2010
September 13-15, 2010
Philadelphia, United States

Tissue Engineering & Regenerative Medicine International Society (TERMIS) – Asia Pacific 2010
September 15-17, 2010
Sydney, Australia

2010 World Stem Cell Summit
October 4-6, 2010
Detroit, United States

5th World Congress on Preventive & Regenerative Medicine (WCRM)
October 5-7, 2010
Hannover, Germany

American Association of Blood Banks (AABB) Annual Meeting & Cellular Therapy and Transfusion Medicine Expo (CTTXPO) 2010
October 9-12, 2010
Baltimore, United States3rd Annual Dubai Congress on Anti-Aging and Aesthetic Medicine (DCAAAM)
October 26-27, 2010
Dubai, United Arab Emirates

World Stem Cells & Regenerative Medicine Congress Asia 2010
October 26-29, 2010
Singapore City, Singapore

Fraunhofer Life Science Symposium 2010
October 29-30, 2010
Leipzig, Germany

Stem Cell Network 10th Annual Scientific Meeting
November 22-24, 2010
Calgary, Canada

Tissue Engineering & Regenerative Medicine International Society (TERMIS) – North America 2010 Annual Conference
December 5-8, 2010
Orlando, United States

Visit our events page to stay up to date with the latest events in the cell, gene and immunotherapy community.


 

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