Volume 11.05 | Feb 15

Cell Therapy News 11.05, February 15, 2010.
In this issue:  Science  |  Policy  |  Business  |  NIH  |  CBER  |  Regulatory  |  Events Unsubscribe


TOP STORY


Biologists Image Birth of Blood-Forming Stem Cells in Embryo
Biologists have identified the specific region in vertebrates where adult blood stem cells arise during embryonic development. [Press release from EurekaAlert! discussing the online prepublication in Nature]

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SCIENCE NEWS

Method of the Future Uses Single-Cell Imaging to Identify Gene Interactions
Researchers have developed a novel method of interpreting data from single-cell images to identify genetic interactions within biological networks, offering a glimpse into the future of high-throughput cell imaging analysis. [Press release from EurekaAlert! discussing the online prepublication in Genome Research]

Czech, United States Scientists Discovery Eases Stem Cells Production
Czech and U.S. scientists have discovered certain regularities in the genesis of mammals' embryos that might simplify the production of stem cells from body cells. [Press release from the Prague Daily Monitor discussing the online prepublication in Current Biology and Biology of Reproduction]

Advanced Cell and Colleagues Report Therapeutic Cells Derived from Induced Pluripotent Stem Cells Display Early Aging
Advanced Cell Technology, Inc. reported that a range of therapeutic cell types obtained from induced pluripotent stem cells exhibit abnormal expansion and early cellular aging. [Press release from Advanced Cell Technology discussing the online prepublication in Stem Cells]

Artificial Lung Tissue Developed for Premies
Researchers worked to create an artificial alveolar-capillary membrane that could one day put an end to the rare but life-threatening condition, pulmonary hypoplasia. [Press release from Johns Hopkins University discussing the online prepublication in the Journal of Pediatric Surgery]

Medical College of Georgia to Conduct First FDA-Approved Stem Cell Trial in Pediatric Cerebral Palsy
Researchers are conducting the first FDA-approved clinical trial to determine whether an infusion of stem cells from umbilical cord blood can improve the quality of life for children with cerebral palsy. [Medical College of Georgia Press Release]

ReNeuron Receives Final Regulatory Approval to Commence Landmark Stroke Clinical Trial in the United Kingdom
ReNeuron Group plc announced that the United Kingdom Gene Therapy Advisory Committee has given a full and final Favourable Opinion to ReNeuron's proposed first-in-man clinical trial with its ReN001 stem cell therapy for stroke. [ReNeuron Group plc Press Release]

StemCells, Inc. Announces First Human Neural Stem Cell Transplant in Landmark Myelination Disorder Trial
StemCells, Inc. announced that its proprietary HuCNS-SC® human neural stem cells have been used to treat the first patient enrolled in its Phase I clinical trial in Pelizaeus-Merzbacher Disease, a myelination disorder that afflicts male children. [StemCells, Inc. Press Release]


CURRENT PUBLICATIONS

Haematopoietic Stem Cells Derive Directly from Aortic Endothelium During Development
Here researchers have used the unique strengths of the zebrafish embryo to image directly the generation of hematopoietic stem cells from the ventral wall of the dorsal aorta. [Nature]

Italy's Stem Cell Challenge Gaining Momentum
Italian scientists are concerned about inappropriate political interference in scientific affairs and intend to continue the fight through the courts, even if it takes years. [Science]

RNA-Targeted Splice-Correction Therapy for Neuromuscular Disease
The trials studied direct antisense oligonucleotide injections into single peripheral lower limb muscles, whereas a viable therapy will need antisense oligonucleotides to be delivered systemically to all muscles, most critically to the heart, and ultimately to all other affected tissues including brain. [Brain]

Genome-Wide Analysis of mRNA Targets for Caenorhabditis elegans FBF, a Conserved Stem Cell Regulator
Researchers use a genome-wide approach to identify putative target mRNAs for the Caenorhabditis elegans PUF protein known as FBF. [Proc Natl Acad Sci U S A]

The Role of Fibroblast Growth Factor-Signaling in Early Neural Specification of Human Embryonic Stem Cells
Human neural induction is instructed by fibroblast growth factor-signaling, though neuralization of human embryonic stem cells can occur in its absence. [Dev Biol

Reconstitution of Experimental Neurogenic Bladder Dysfunction Using Skeletal Muscle-Derived Multipotent Stem Cells
Investigators attempted to reconstitute disrupted bladder branch of the pelvic plexus and blood vessels using skeletal muscle-derived multipotent stem cells that show synchronized reconstitution capacity of vascular, muscular, and peripheral nervous systems. [Transplantation]

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POLICY

Medvedev Talks Science in Moscow
Russian science has been getting some bad press recently, what with a recent report on its declining productivity in scientific papers and a letter from expatriate scientists to the Russian president and prime minister warning of the parlous state of basic research. [Russian Academy of Sciences, Russia]

New 10-Year United Kingdom Blood Stem Cell Strategy to be Created
Gillian Merron, Public Health Minister, has asked the National Health Service Blood and Transplant to lead a team of experts in creating a new 10-year strategy for the provision of blood stem cells, including those from cord blood to fight leukaemias and other blood disorders. [National Health Service Blood and Transplant, United States]

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BUSINESS

Data Monitoring Committee Recommends Continuation of Phase III Study of StemEx®, a Cord Blood Stem Cell Product, for Leukemia and Lymphoma
The Gamida Cell-Teva Joint Venture (JV) announced that the Data Monitoring Committee has independently reviewed preliminary data from the pivotal registration, Phase III clinical trial of StemEx and has recommended that the JV continue to enroll patients in this study. [Gamida Cell Ltd. Press Release]

Living Cell Technologies Awarded NZ$4.04 Million New Zealand Government Grant to Advance DIABECELL® for Type 1 Diabetes
Cell implant company Living Cell Technologies Limited announced that it has been awarded a grant of NZ$4.04 million from the New Zealand government’s Foundation for Research Science & Technology. [Living Cell Technologies Limited Press Release]

Living Cell Technologies Receives 10% of US Based Wound Healing Company in Supply and Licence Agreement
Living Cell Technologies Limited announced that it has received 10% ownership of CytoSolv Inc. in exchange for restricted supply of choroid plexus cell clusters from its designated pathogen free pig herd and granting CytoSolv a non-exclusive, non-transferable licence to use its broad choroid plexus patents solely for the purpose of wound healing. [Living Cell Technologies Limited Press Release]

Alnylam Receives Notice of Allowance from United States Patent and Trademark Office for New Patent Broadly Covering RNAi Therapeutics
Alnylam Pharmaceuticals, Inc. announced that the United States Patent and Trademark Office has awarded a Notice of Allowance for the “Soutschek and Manoharan” patent (Application No. 10/916,185), which covers certain chemically modified siRNAs of any length directed to any target, including siRNAs with sterol conjugates for in vivo delivery. [Alnylam Pharmaceuticals, Inc. Press Release]

£6 Million to be Invested in Further Regenerative Medicine Research and Development
The Technology Strategy Board is to invest a further £6m in regenerative medicine research and development and has invited British companies to bid for funding through two new competitions. [Technology Strategy Board Press Release]

Athersys Receives United States Patent Covering Adult Stem Cell Composition & Production
Athersys, Inc. announced that it has been granted U.S. patent 7,659,118 that covers non-embryonic multipotent stem cells, their isolation and expansion, and related pharmaceutical compositions. [Athersys, Inc. Press Release]

Cartilage Replacement Therapy
Fusion IP has created Progenteq, a new Cardiff University spin-out developing a novel cartilage replacement therapy for use in treating acute knee injuries. [The Engineer]



NIH

Delays in Grant Application Submission due to Widespread Winter Storm (NOT-OD-10-061)

Recovery Act Limited Competition: Program to Enhance National Institutes of Health-Supported Global Health Research Involving Human Subjects (S07) (RFA-OD-10-006)

Institutional Clinical and Translational Science Award (U54) (RFA-RM-10-001)

Notice of Intent to Establish a New National Institutes of Health Common Fund Program: Library of Integrated Network-Based Cellular Signatures (LINCS) (NOT-RM-10-002)

Investigator Initiated Multi-Site Clinical Trials (Collaborative R01) (PAR-10-096)



CBER

U.S. Food and Drug Administration Statement: The Impact of February’s Inclement Weather on Prescription Drug User Fee Act and Medical Device User Fee Act Deadlines



REGULATORY 

THERAPEUTIC GOODS ADMINISTRATION (Australia)

Expressions of Interest for Membership of the Therapeutic Goods Committee



EVENTS

14th Annual Hilton Head Workshop
March 10-14, 2010
Hilton Head Island, United States

12th Biennial Canadian Blood and Marrow Transplant (CBMT) Consortium Meeting
April 7-10, 2010
Vancouver, Canada

American Association for Cancer Research (AACR) 101st Annual Meeting 2010
April 17-21, 2010
Washington, DC, United States

Society for Biological Engineering's (SBE) 2nd International Conference on Stem Cell Engineering
May 2-5, 2010
Boston, United States

World Stem Cells & Regenerative Medicine Congress 2010
May 12-14, 2010
London, United Kingdom

16th International Society for Cellular Therapy (ISCT) Meeting
May 23-26, 2010
Philadelphia, United States

International Society for Stem Cell Research (ISSCR) 8th Annual Meeting
June 16-19, 2010
San Francisco, United States

United Kingdom National Stem Cell Network (UKNSCN) 3rd Annual Scientific Conference
July 12-14, 2010
Nottingham, United Kingdom

International Society of Cell Therapy (ISCT) Annual Meeting – Europe
September 11-14, 2010
Belgirate, Italy

5th World Congress on Preventive & Regenerative Medicine (WCRM)
October 5-7, 2010
Hannover, Germany


 

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