Volume 10.19 | May 25

Cell Therapy News 10.19, May 25, 2009
     In this issue: Science | Policy | Business | NIH | CBER | Regulatory
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Top Stories

Genetically-Engineered MSCs Kill Metastatic Lung Cancer Cells in Mice: Researchers in London have demonstrated the ability of adult stem cells from bone marrow to deliver a cancer-killing protein to tumors.
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Science

VIDEO: Isolate Specific Cell Types from Human blood
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Stem Cells Hold Promise in Treating Retinal Degeneration
A team of University of Louisville scientists have discovered that stem cells taken from bone marrow can restore damaged retinal tissue by generating new cells.
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The Future of Personalized Cancer Treatment: An Entirely New Direction for RNAi Delivery
In technology that promises to one day allow drug delivery to be tailored to an individual patient and a particular cancer tumor, researchers have developed an efficient system for delivering siRNA into primary cells.
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University of the Basque Country Researcher Develops Nanoparticles to be Used in Genic Therapy
Genic therapy can be used both with rare diseases, such as cystic fibrosis and disorders of the retina, as well as with more common illnesses, such as AIDS, cancer and neurodegenerative diseases.
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Study Points Toward Relationship between Cancer Stem Cells and Prognosis in Primary Breast Cancer
In the first prospective study to investigate the presence of breast cancer stem cells of primary breast cancer patients. The results suggest the need for additional biological therapies, and a promising new direction for the study of micro-metastasis.
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Using High-precision Laser Tweezers To Juggle Cells
Researchers at the University of Gothenburg, Sweden, have developed a new method to study single cells while exposing them to controlled environmental changes.
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How an Enzyme Tells Stem Cells Which Way to Divide
University of Oregon biochemists report a mechanism dictating cell division is not a long cascade of events.
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New Tool Isolates RNA Within Specific Cells
University of Oregon biologists provide quick, precise view of cell development and gene expression.
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New Approach Protects Monkeys from a Virus that Closely Resembles HIV
Researchers have managed to protect monkeys from infection with the simian immunodeficiency virus (SIV), the animal model that is closest to HIV, by shuttling a gene into their muscles that produces antibody-like molecules.
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New Strategies for Cell Therapy to Regenerate Damaged Heart
Research undertaken at the Center for Applied Medical Research and the University Hospital of Navarra has shown that, in animal models, stem cells derived from bone marrow and adipose tissue enhance heart function after a cardiac attack.
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Pervasis Therapeutics Presents Promising Preclinical Data for its Minimally Invasive Cell Therapy
Results from the preclinical study found that treatment with allogeneic endothelial cells following an intervention for peripheral arterial disease resulted in a statistically significant increased lumen area, reduced intimal area, and decreased occlusion compared to control.
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Cell Therapy Successful in Severe Cases of Angina Pectoris in Heart Patients
A new treatment involving the injection of bone marrow cells is beneficial to people who suffer from a severe form of angina pectoris.
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Aastrom Proactively Places Phase II IMPACT-DCM Clinical Trial On Hold Following Report of Serious Adverse Event
Aastrom Biosciences, Inc. recently announced that the Company has temporarily suspended enrollment and patient treatment in its U.S. Phase II IMPACT-DCM clinical trial following a report that a patient died at home after being released from the hospital following treatment in the trial.
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ABSTRACTS, REVIEWS AND SPECIAL REPORTS

Characterization of Dendritic Cells and Macrophages Generated by Directed Differentiation from Mouse Induced Pluripotent Stem Cells
The researchers have demonstrated the induction of anti-cancer immunity and prevention of autoimmune disease by in vivo administration of genetically engineered human embryonic-dendritic stem cells. [Stem Cells]
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Muscle Contraction Is Necessary to Maintain Joint Progenitor Cell Fate
This study provides the missing link between progenitor cell fate determination and embryonic movement, two processes shown to be essential for correct organogenesis. [Developmental Cell]
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Policy

STEMSOFT Software Inc. Releases White Paper on Electronic Records in Cell Therapy – Regulatory and Accreditation Requirements
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Obama Talks of Common Ground Amid Notre Dame Protests
Amid protests over his positions on abortion and embryonic stem-cell research, President Obama spoke to graduates at the University of Notre Dame about coming together over disagreements by finding “common ground.”
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Bush Bioethics Advisors Take Potshot at Obama Stem Cell Platform
Prestigious Hastings Center bioethics think tank publishes comments by more than half of President Bush’s bioethics council.
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New Democratic Coalition Proposes Independent Panel To Oversee Comparative Effectiveness Research
Members of the moderate New Democratic Coalition on Tuesday proposed legislation (HR 2502) that would establish a non-governmental, independent office to oversee research efforts to compare the effectiveness of medical treatments.
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Business

Connexon Creative Launches Mammary Cell News
Mammary Cell News is a weekly e-newsletter that keeps members of the mammary cell community informed by providing the latest news from all areas of the field, including its science, research and business.

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Victoria, Australia and California Form Stem Cell Alliance
Victorian Innovation Minister Gavin Jennings announced four collaborative grants between Victorian and Californian teams.
Article

UC Davis Opens Horse Stem Cell Lab
The Regenerative Medicine Laboratory at the William R. Pritchard Veterinary Medical Teaching Hospital allows for processing, culturing and storing stem cells for horses.
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Oklahoma Stem Cell Research Gets $5.5M
The Tobacco Settlement Endowment Trust board voted Monday to contribute $5.5 million to adult stem cell research.
Article

University of Iowa Center for Gene Therapy Receives $5.5 Million Grant Renewal
The University of Iowa Center for Gene Therapy has received a five-year, $5.5 million grant renewal from the National Institute of Diabetes and Digestive and Kidney Diseases, one of the National Institutes of Health.
Article

Governments Dole out $41M to Projects at University of Manitoba
The University of Manitoba was given a $41-million boost from the federal and provincial governments on Thursday.
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KPCB Invests $15M in Chinese Biotech Firm
The Chinese arm of the U.S. venture capital fund Kleiner Perkins Caufield & Byers, has invested in a biotechnology firm in eastern China for $15 million.
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Novocell Awarded Patent for Innovative Stem Cell Therapy for Diabetes
Novocell, Inc. recently announced that it has received U.S. Patent No. 7,534,608 with method claims covering the Company’s innovative stem cell therapy for the production of functional pancreatic, insulin producing cells from human embryonic stem cells.
Article

Stem Cell Therapeutics Announces Issuance of Additional US Patent for Use of Prolactin
Stem Cell Therapeutics Corp. has been issued United States Patent No. 7,534,765 covering methods of using of prolactin for enhancing the formation of oligodendendrocytes in vivo.
Article

Stem Cell Therapeutics Corp. Releases Encouraging Clinical Results and Provides Corporate Update
Stem Cell Therapeutics has decided to commence the modified Phase IIb REGENESIS clinical stroke trial as soon as possible, with the goal of completing patient enrollment by the end of 2009.
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NIH

Ac”cell”erate your research with the NIH stimulus package and Robosep(R)
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Draft NIH Human Stem Cell Guidelines Comments Form: Deadline 11:00pm EST on May 26, 2009. 
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Public Comments Sought on Regulations for Financial Conflicts of Interest in Federally-Funded Research
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Reminder and Clarification of NIH Policies on Similar, Identical, or Essentially Identical Applications, Submission of Applications Following RFA Review, and Submission of Applications with a Changed Activity Code (NOT-OD-09-100)
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Notice of Clarification to PAR-09-016, Innovation in Molecular Imaging Probes (R01) (NOT-EB-09-001)
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CBER

Vaccines and Related Biological Products Advisory Committee
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Current Licensed Establishments and Products
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Regulatory

FOOD AND DRUG ADMINISTRATION (United States)

Obama’s US FDA Pick Wins Senate Clearance
The U.S. Senate voted on Monday to confirm Dr. Margaret Hamburg to run the Food and Drug Administration, the agency that oversees a vast array of products from foods to prescription drugs and medical devices.
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