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Gene Therapy Shows Promise as Weapon Against HIV
A new UCLA AIDS Institute study has found that gene therapy can be developed as a safe and active technique to combat HIV.
‘Evolved’ Virus may Improve Gene Therapy for Cystic Fibrosis
Researchers have turned a relatively benign virus into a highly infectious form that is ideal as a carrier for gene therapy, completely curing human cystic fibrosis lung tissue in culture in its first gene therapy test.
Stem Cells’ Deathly Awakening by Interferon
Interferon-alpha, a messenger substance of the immune system, awakens dormant hematopoietic stem cells in the bone marrow to become active, thus making them vulnerable for the effect of many drugs German researchers have shown.
University of Texas Houston Launches Stem Cell Study for Acute Stroke Patients
Researchers will enroll 10 patients in the phase 1 study, who have just suffered a stroke, and will use the patients’ own stem cells for treatment.
Case Report of a Brain and Spinal Tumor Following Human Fetal Stem Cell Therapy
Researchers recently report the case of a boy with a rare genetic disease, Ataxia Telangiectasia, who underwent human fetal stem cell therapy at a clinic in Moscow and who, four years after the therapy began, was shown to have abnormal growths in his brain and spinal cord.
New Therapy with Stem Cells to Treat Crohn’s Disease
Hospital Clinic, Barcelona is exploring an innovative cellular therapy that uses stem cells to treat Crohn’s disease, a chronic genetic disease that affects 1% of the population in Spain and which has considerable impact on the quality of life of patients.
Unrelated and Mismatched Cord Blood Transplantation Can Still Help Children with Deadly Conditions
An unrelated cord blood transplant, even from a mismatched donor, can be effective in treating children with a host of life-threatening diseases and disorders according to researchers in the Duke Pediatric Blood and Marrow Transplantation Program.
Long Term Results of a Successful Phase I Clinical Trial Using Autologous Neural Stem Cells to Treat Parkinson’s Disease
Scientists announced recently research describing the long term results of the world’s first clinical trial using autologous neural stem cells for the treatment of Parkinson’s Disease.
Neuralstem’s ALS Trial on Clinical Hold
Neuralstem, Inc. announced recently its spinal cord stem cell trial to treat ALS is on clinical hold and that the Federal Drug Administration has provided the Company with specific comments, questions and recommendations for modifications to its protocol.
Winners of the Stem Cell Image Contest Announced by the California Institute for Regenerative Medicine
The twelve winning images from the first California Institute for Regenerative Medicine stem cell image contest range from a whirling galaxy of developing nerve cells to a moonscape of retinal pigment epithelial cells, both derived from human embryonic stem cells.
ABSTRACTS, REVIEWS AND SPECIAL REPORTS
A Multi-instrumental Approach to Identify and Purify Very Small Embryonic-like Stem Cells from Adult Tissues
In this paper, the researchers employed several complementary cell image analytical methods including ImageStream system (ISS analysis) and molecular approaches to identify and purify from adult murine organs a population of very small embryonic-like stem cells.
A Rosette-type, Self-renewing Human ES Cell-derived Neural Stem Cell with Potential for in Vitro Instruction and Synaptic Integration
Here, the researchers present a pure population of long-term self-renewing rosette-type hESC-derived neural stem cells (lt-hESNSCs), which exhibit extensive self-renewal, clonogenicity, and stable neurogenesis.
Immunogenicity of Allogeneic Adipose-derived Stem Cells in a Rat Spinal Fusion Model
To determine whether adipose-derived stem cells express a non-immunogenic profile in vivo, immune monitoring studies were carried out in conjunction with a rat spinal fusion study.
A Multi-center, Randomized, Clinical Study to Compare the Effect and Safety of Autologous Cultured Osteoblast Injection to Treat Fractures
The researchers performed a multi-center, open, randomized, clinical study of autologous cultured osteoblast injection for long-bone fracture, to evaluate the fracture healing acceleration effect and the safety of autologous cultured osteoblasts.
Neuronal Guidance Protein Netrin-1 Induces Differentiation in Human Embryonal Carcinoma Cells
This study suggests that Netrin-1 can induce neuroectodermal-like differentiation of human EC cells by affecting c-src signaling via SHP-2 activation and regulation of Nanog, Oct4, and Cripto-1 expressions.
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