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Japanese Stem Cell Scientist Turn Stem Cells into Platelets
A Japanese research team headed by University of Tokyo Professor Hiromitsu Nakauchi announced this week that they had turned human stem cells into platelets.
Don’t Go Changing: New Chemical Keeps Stem Cells Young
Scientists at the Universities of Bath and Leeds have discovered a chemical that stops stem cells from turning into other cell types, allowing researchers to use these cells to develop new medical treatments more easily.
Cloned Human Embryos Successfully Reprogrammed Using Human, But Not Animal Eggs
The research published recently demonstrates that although human-to-human clones and human-to-animal clones appear similar, the pattern of reprogramming of the donor human cell is dramatically different.
University of Minnesota Researchers Find Master Gene Behind Blood Vessel Development
Using genetically engineered mice, researchers were able to identify a protein, Nkx2-5, which activates a certain gene, and in turn, determines the fate of a group of cells in a developing embryo.
Australian First for Melbourne Stem Cell Scientists
Melbourne scientists have created Australia’s first induced pluripotent stem cell lines.
UC San Diego Engineers Develop Novel Method for Accelerated Bone Growth
Engineers at the University of California at San Diego have come up with a way to help accelerate bone growth through the use of nanotubes and stem cells.
‘Sister’ Factors Promote Survival of Blood-system Stem Cells
Researchers from the Baylor College of Medicine demonstrate that two specific “sister” genes that control transcription play often overlapping roles in maintaining this pool of hematopoietic or blood cell-forming stem cells.
Stem Cells in Hair Follicles Point to General Model of Organ Regeneration
New research from Rockefeller University reveals that a structure at the base of each strand of hair, the hair follicle, uses a two-step mechanism to activate its stem cells and order them to divide.
Stem Cell Transplants Show Promise for Multiple Sclerosis
Researchers from Northwestern University’s Feinberg School of Medicine appear to have reversed the neurological dysfunction of early-stage multiple sclerosis patients by transplanting their own immune stem cells into their bodies.
Cell-building Discovery Could Reduce Need for Some Animal Research
Brown University biomedical engineers, using a 3-D Petri dish they invented, have successfully built complex-shaped microtissues by assembling small building blocks of living cell clusters.
Potential New Herpes Therapy Studied
A new therapy being developed at the University of Florida employs a gene-targeting approach using a specially designed RNA enzyme to inhibit strains of the herpes simplex virus.
International Stem Cell Corporation Begins Pre-Clinical Trials on Human Corneal Epithelial Cells
International Stem Cell Corporation is planning pre-clinical trials aimed at applying its laboratory-grown human corneal epithelial cells to improve photorefractive keratectomy, a form of corrective laser eye surgery.
First Patient Treated in Adipose Stem & Regenerative Cell Study for Stress Urinary Incontinence
Cytori recently announced that the first patient was enrolled in an investigator-initiated safety and feasibility study using adipose-derived stem and regenerative cells to treat stress urinary incontinence.
ABSTRACTS, REVIEWS AND SPECIAL REPORTS
Oct4-Induced Pluripotency in Adult Neural Stem Cells
In this report, the researchers show that only exogenous expression of the germline-specific transcription factor Oct4 is sufficient to generate pluripotent stem cells from adult mouse NSCs.
The Influence of Three-dimensional Nanofibrous Scaffolds on the Osteogenic Differentiation of Embryonic Stem Cells
In this study, the researchers examine the effects of nanofibrous architecture and biochemical cues on the osteogenic differentiation of embryonic stem cells compared to the more traditional architecture without the nanofibrous features in two dimensions (thin matrix or flat films) and three dimensions (scaffolds) in vitro.
The OP9-DL1 System: Generation of T-Lymphocytes from Embryonic or Hematopoietic Stem Cells in Vitro
This paper describes an approach providing a simple, versatile, and efficient culture system that allows for the commitment, differentiation, and proliferation of T-lineage cells from different sources of stem cells.
Gene Therapy for Bladder Overactivity and Nociception with Herpes Simplex Virus Vectors Expressing Preproenkephalin
The researchers studied the effect of targeted and localized expression of enkephalin in afferent nerves that innervate the bladder by gene transfer using replication-defective herpes simplex virus vectors in a rat model of bladder hyperactivity and pain.
Clinical Responses to Gene Therapy in Joints of Two Subjects with Rheumatoid Arthritis
This paper describes two subjects with rheumatoid arthritis that received ex vivo, intra-articular delivery of human interleukin-1 receptor antagonist (IL-1Ra) cDNA.
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