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Biologists at Tufts University Discover Link Between CGG Repeats and DNA Damage
Scientists at Tufts University have found that repetitive DNA sequences are associated with hereditary neurological disorders such as fragile X syndrome and FRAXE mental impairment.
Special Nanotubes May Be Used as a Vehicle for Treating Neurodegenerative Disorders
Electrical engineering researchers at the University of Arkansas have demonstrated that magnetic nanotubes combined with nerve growth factor can enable specific cells to differentiate into neurons.
Large DNA Stretches, Not Single Genes, Shut Off as Cells Mature
Experiments at Johns Hopkins have found that the gradual maturing of embryonic cells into cells as varied as brain, liver and immune system cells is apparently due to the shut off of several genes at once rather than in individual smatterings as previous studies have implied.
Novel Cell Lines Propel the Search for Safer Stem Cell Induction
Whitehead Institute researchers have reliably produced mice and mouse cell lines with identical configurations of the specific factors needed to reprogram adult cells to an embryonic-stem-cell-like state.
Mesoblast Stem Cells Approved for World First Osteoarthritis Clinical Trial
Mesoblast Limited recently announced that it had received Australian institutional ethics approval to begin the first human trial of adult stem cell treatment for prevention of knee osteoarthritis after an acute traumatic knee injury.
Stem Cell Treatment Could Fight Aids
Results of a preliminary trial involving isolating genes which curb the spread of HIV inside the body, introducing the genes into human stem cells in a laboratory, then transplanting the stem cells into a patient’s bone marrow have raised hopes for people suffering from Aids.
ReNeuron Gains UK Regulatory Approval to Start Ground-breaking Clinical Trial with Stem Cell Therapy for Stroke
ReNeuron Group plc recently announced that it has received approval from the UK Medicines and Healthcare Products Regulatory Agency to commence a first-in-man clinical trial for the treatment of patients who have been left disabled by an ischaemic stroke, the most common form of the condition.
VIDEO: Embryonic Stem Cell-Derived Endothelial Cells for Treatment of Hindlimb Ischemia
The surgical procedure for delivery of embryonic stem cell-derived endothelial cells to the ischemic hindlimb is demonstrated, with non-invasive tracking by bioluminescence imaging.
ABSTRACTS, REVIEWS AND SPECIAL REPORTS
Proteomic Characterisation of the Conditioned Media Produced by the Visceral Endoderm-like Cell Lines HepG2 and End2: Towards a Defined Medium for the Osteogenic/Chondrogenic Differentiation of Embryonic Stem Cells
This study utilized the conditioned media from the visceral endoderm-like cell lines, HepG2 and END2, to enhance lineage-specific differentiation of murine ESCs towards the osteogenic lineage.
A Method for Isolating Pluripotent/Multi-potent Stem Cells from Blood by Using the Pluripotent and Germ-line DAZL Gene as a Marker
The researchers have shown for the first time that pluripotent/multi-potent stem cells can be isolated from blood in a relatively simple cell separation, which is fast and compatible with current standards.
Reductive Isolation from Bone Marrow and Blood Implicates Common Lymphoid Progenitors as the Major Source of Thymopoiesis
Here the researchers took a comprehensive approach to prospectively identify the major source of thymocyte progenitors that reside within the BM and blood, and find that all thymocyte progenitor activity resides within a rare Flk2+CD27+ population.
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